FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775239105> ?p ?o ?g. }

• W2775239105 endingPage "391" @default.
• W2775239105 startingPage "386" @default.
• W2775239105 abstract "BackgroundAndrogens are generally immunosuppressive, and men with untreated hypogonadism are at increased risk for autoimmune conditions. To date, there has been no evidence linking androgen deprivation therapy (ADT) to autoimmune diseases, including rheumatoid arthritis (RA). We investigated the association between ADT and RA in patients with prostate cancer.Patients and methodsWe identified 105 303 men age 66 years or older who were diagnosed with stages I–III prostate cancer from 1992 through 2006 using the Surveillance, Epidemiology, and End Results-Medicare linked database, excluding patients with a history of RA. χ2 test was used to compare 5-year Kaplan–Meier rates of RA diagnoses. Competing risk Cox regression using inverse probability of treatment weighting was utilized to examine the association between pharmacologic ADT and diagnosis of RA.ResultsThe 43% of patients (N = 44 785) who received ADT experienced a higher 5-year rate of RA diagnoses compared with men who did not (5.4% versus 4.4%, P < 0.001). Receipt of any ADT was associated with a 23% increased risk of being diagnosed with RA (hazard ratio 1.23, 95% confidence interval 1.09–1.40, P = 0.001). The risk of being diagnosed with RA increased with a longer duration of ADT, from 19% with 1–6 months and 29% with 7–12 months to 33% with ≥13 months (Ptrend < 0.001).ConclusionsConsistent with the immunosuppressive properties of androgens, we demonstrated for the first time that ADT was associated with an elevated risk of being diagnosed with RA in this large cohort of elderly men with prostate cancer. The risk was higher with a longer duration of ADT. Linking ADT to an increased risk of being diagnosed with an autoimmune condition adds to mounting evidence of the adverse effects of ADT that should prompt physicians to thoughtfully weigh its risks and benefits." @default.
• W2775239105 created "2017-12-22" @default.
• W2775239105 creator A5005203538 @default.
• W2775239105 creator A5015096941 @default.
• W2775239105 creator A5024676913 @default.
• W2775239105 creator A5027932946 @default.
• W2775239105 creator A5052504518 @default.
• W2775239105 creator A5061395570 @default.
• W2775239105 creator A5073701206 @default.
• W2775239105 creator A5076238068 @default.
• W2775239105 creator A5077545940 @default.
• W2775239105 creator A5078458765 @default.
• W2775239105 creator A5085318253 @default.
• W2775239105 date "2018-02-01" @default.
• W2775239105 modified "2023-10-14" @default.
• W2775239105 title "Androgen deprivation therapy and risk of rheumatoid arthritis in patients with localized prostate cancer" @default.
• W2775239105 cites W1761408206 @default.
• W2775239105 cites W1968072906 @default.
• W2775239105 cites W1997732940 @default.
• W2775239105 cites W2009432885 @default.
• W2775239105 cites W2027653773 @default.
• W2775239105 cites W2030521036 @default.
• W2775239105 cites W2073393820 @default.
• W2775239105 cites W2081052928 @default.
• W2775239105 cites W2097930057 @default.
• W2775239105 cites W2102070262 @default.
• W2775239105 cites W2102918897 @default.
• W2775239105 cites W2121477019 @default.
• W2775239105 cites W2131170102 @default.
• W2775239105 cites W2157358083 @default.
• W2775239105 cites W2165664782 @default.
• W2775239105 cites W2192798466 @default.
• W2775239105 cites W2338601986 @default.
• W2775239105 cites W2441690768 @default.
• W2775239105 cites W2472523518 @default.
• W2775239105 cites W4211111012 @default.
• W2775239105 doi "https://doi.org/10.1093/annonc/mdx744" @default.
• W2775239105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29267861" @default.
• W2775239105 hasPublicationYear "2018" @default.
• W2775239105 type Work @default.
• W2775239105 sameAs 2775239105 @default.
• W2775239105 citedByCount "17" @default.
• W2775239105 countsByYear W27752391052018 @default.
• W2775239105 countsByYear W27752391052019 @default.
• W2775239105 countsByYear W27752391052020 @default.
• W2775239105 countsByYear W27752391052021 @default.
• W2775239105 countsByYear W27752391052022 @default.
• W2775239105 countsByYear W27752391052023 @default.
• W2775239105 crossrefType "journal-article" @default.
• W2775239105 hasAuthorship W2775239105A5005203538 @default.
• W2775239105 hasAuthorship W2775239105A5015096941 @default.
• W2775239105 hasAuthorship W2775239105A5024676913 @default.
• W2775239105 hasAuthorship W2775239105A5027932946 @default.
• W2775239105 hasAuthorship W2775239105A5052504518 @default.
• W2775239105 hasAuthorship W2775239105A5061395570 @default.
• W2775239105 hasAuthorship W2775239105A5073701206 @default.
• W2775239105 hasAuthorship W2775239105A5076238068 @default.
• W2775239105 hasAuthorship W2775239105A5077545940 @default.
• W2775239105 hasAuthorship W2775239105A5078458765 @default.
• W2775239105 hasAuthorship W2775239105A5085318253 @default.
• W2775239105 hasBestOaLocation W27752391051 @default.
• W2775239105 hasConcept C121608353 @default.
• W2775239105 hasConcept C126322002 @default.
• W2775239105 hasConcept C143998085 @default.
• W2775239105 hasConcept C207103383 @default.
• W2775239105 hasConcept C2777575956 @default.
• W2775239105 hasConcept C2777899217 @default.
• W2775239105 hasConcept C2780192828 @default.
• W2775239105 hasConcept C44249647 @default.
• W2775239105 hasConcept C50382708 @default.
• W2775239105 hasConcept C71924100 @default.
• W2775239105 hasConcept C72563966 @default.
• W2775239105 hasConceptScore W2775239105C121608353 @default.
• W2775239105 hasConceptScore W2775239105C126322002 @default.
• W2775239105 hasConceptScore W2775239105C143998085 @default.
• W2775239105 hasConceptScore W2775239105C207103383 @default.
• W2775239105 hasConceptScore W2775239105C2777575956 @default.
• W2775239105 hasConceptScore W2775239105C2777899217 @default.
• W2775239105 hasConceptScore W2775239105C2780192828 @default.
• W2775239105 hasConceptScore W2775239105C44249647 @default.
• W2775239105 hasConceptScore W2775239105C50382708 @default.
• W2775239105 hasConceptScore W2775239105C71924100 @default.
• W2775239105 hasConceptScore W2775239105C72563966 @default.
• W2775239105 hasIssue "2" @default.
• W2775239105 hasLocation W27752391051 @default.
• W2775239105 hasLocation W27752391052 @default.
• W2775239105 hasOpenAccess W2775239105 @default.
• W2775239105 hasPrimaryLocation W27752391051 @default.
• W2775239105 hasRelatedWork W1963763301 @default.
• W2775239105 hasRelatedWork W2035098213 @default.
• W2775239105 hasRelatedWork W2728894889 @default.
• W2775239105 hasRelatedWork W2753537866 @default.
• W2775239105 hasRelatedWork W2896276799 @default.
• W2775239105 hasRelatedWork W2915731681 @default.
• W2775239105 hasRelatedWork W2994686985 @default.
• W2775239105 hasRelatedWork W3111778365 @default.
• W2775239105 hasRelatedWork W4200552296 @default.
• W2775239105 hasRelatedWork W4240979600 @default.

• next