Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775243775> ?p ?o ?g. }
- W2775243775 abstract "SUMMARY Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent, Mycobacterium ulcerans , derives from Mycobacterium marinum by genomic reduction and acquisition of a plasmid-borne, nonribosomal cytotoxin mycolactone, the major virulence factor. M. ulcerans -specific sequences have been readily detected in aquatic environments in food chains involving small mammals. Skin contamination combined with any type of puncture, including insect bites, is the most plausible route of transmission, and skin temperature of <30°C significantly correlates with the topography of lesions. After 30 years of emergence and increasing prevalence between 1970 and 2010, mainly in Africa, factors related to ongoing decreasing prevalence in the same countries remain unexplained. Rapid diagnosis, including laboratory confirmation at the point of care, is mandatory in order to reduce delays in effective treatment. Parenteral and potentially toxic streptomycin-rifampin is to be replaced by oral clarithromycin or fluoroquinolone combined with rifampin. In the absence of proven effective primary prevention, avoiding skin contamination by means of clothing can be implemented in areas of endemicity. Buruli ulcer is a prototype of ecosystem pathology, illustrating the impact of human activities on the environment as a source for emerging tropical infectious diseases." @default.
- W2775243775 created "2017-12-22" @default.
- W2775243775 creator A5016032557 @default.
- W2775243775 creator A5049546731 @default.
- W2775243775 creator A5060298701 @default.
- W2775243775 creator A5064706278 @default.
- W2775243775 date "2018-01-01" @default.
- W2775243775 modified "2023-10-18" @default.
- W2775243775 title "Buruli Ulcer, a Prototype for Ecosystem-Related Infection, Caused by Mycobacterium ulcerans" @default.
- W2775243775 cites W1175437893 @default.
- W2775243775 cites W137079655 @default.
- W2775243775 cites W1500348573 @default.
- W2775243775 cites W1508310914 @default.
- W2775243775 cites W1510512673 @default.
- W2775243775 cites W1529843719 @default.
- W2775243775 cites W1530181177 @default.
- W2775243775 cites W1534008178 @default.
- W2775243775 cites W1537075863 @default.
- W2775243775 cites W1543546710 @default.
- W2775243775 cites W1565250952 @default.
- W2775243775 cites W1583956733 @default.
- W2775243775 cites W1584725440 @default.
- W2775243775 cites W1588602846 @default.
- W2775243775 cites W1599656452 @default.
- W2775243775 cites W172462697 @default.
- W2775243775 cites W1743714153 @default.
- W2775243775 cites W1769237235 @default.
- W2775243775 cites W1769972931 @default.
- W2775243775 cites W1826036848 @default.
- W2775243775 cites W1827239630 @default.
- W2775243775 cites W1902845956 @default.
- W2775243775 cites W1927193681 @default.
- W2775243775 cites W1968611735 @default.
- W2775243775 cites W1970738333 @default.
- W2775243775 cites W1971327283 @default.
- W2775243775 cites W1971516677 @default.
- W2775243775 cites W1972269596 @default.
- W2775243775 cites W1974450924 @default.
- W2775243775 cites W1975547334 @default.
- W2775243775 cites W1976586739 @default.
- W2775243775 cites W1977002488 @default.
- W2775243775 cites W1977797213 @default.
- W2775243775 cites W1978888385 @default.
- W2775243775 cites W1979090690 @default.
- W2775243775 cites W1980412810 @default.
- W2775243775 cites W1980490998 @default.
- W2775243775 cites W1982879481 @default.
- W2775243775 cites W1983202667 @default.
- W2775243775 cites W1985450923 @default.
- W2775243775 cites W1986817846 @default.
- W2775243775 cites W1988627324 @default.
- W2775243775 cites W1989033654 @default.
- W2775243775 cites W1989152374 @default.
- W2775243775 cites W1989378439 @default.
- W2775243775 cites W1989769881 @default.
- W2775243775 cites W1989885244 @default.
- W2775243775 cites W1989932101 @default.
- W2775243775 cites W1992288339 @default.
- W2775243775 cites W1992470594 @default.
- W2775243775 cites W1992583726 @default.
- W2775243775 cites W1992647391 @default.
- W2775243775 cites W1993599320 @default.
- W2775243775 cites W1994105987 @default.
- W2775243775 cites W1994258467 @default.
- W2775243775 cites W1994477168 @default.
- W2775243775 cites W1995408407 @default.
- W2775243775 cites W1996443622 @default.
- W2775243775 cites W1996488137 @default.
- W2775243775 cites W1996849780 @default.
- W2775243775 cites W1997239423 @default.
- W2775243775 cites W1997443329 @default.
- W2775243775 cites W1998117938 @default.
- W2775243775 cites W2000425180 @default.
- W2775243775 cites W2000750812 @default.
- W2775243775 cites W2003968297 @default.
- W2775243775 cites W2004853726 @default.
- W2775243775 cites W2005070464 @default.
- W2775243775 cites W2005438416 @default.
- W2775243775 cites W2005671213 @default.
- W2775243775 cites W2006190430 @default.
- W2775243775 cites W2009202205 @default.
- W2775243775 cites W2011457301 @default.
- W2775243775 cites W2011519576 @default.
- W2775243775 cites W2011611130 @default.
- W2775243775 cites W2012129122 @default.
- W2775243775 cites W2014064134 @default.
- W2775243775 cites W2014578814 @default.
- W2775243775 cites W2015510212 @default.
- W2775243775 cites W2016150993 @default.
- W2775243775 cites W2016326246 @default.
- W2775243775 cites W2017551481 @default.
- W2775243775 cites W2020115772 @default.
- W2775243775 cites W2022217880 @default.
- W2775243775 cites W2022315744 @default.
- W2775243775 cites W2024829197 @default.
- W2775243775 cites W2025487514 @default.
- W2775243775 cites W2025946099 @default.
- W2775243775 cites W2026100882 @default.
- W2775243775 cites W2026449587 @default.
- W2775243775 cites W2026650188 @default.