FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775261220> ?p ?o ?g. }

• W2775261220 endingPage "716" @default.
• W2775261220 startingPage "705" @default.
• W2775261220 abstract "Abstract Syd-1 proteins are required for presynaptic development in worm, fly, and mouse. Syd-1 proteins in all three species contain a Rho GTPase activating protein (GAP)-like domain of unclear significance: invertebrate Syd-1s are thought to lack GAP activity, and mouse mSYD1A has GAP activity that is thought to be dispensable for its function. Here, we show that Drosophila melanogaster Syd-1 can interact with all six fly Rhos and has GAP activity toward Rac1 and Cdc42. During development, fly Syd-1 clusters multiple presynaptic proteins at the neuromuscular junction (NMJ), including the cell adhesion molecule Neurexin (Nrx-1) and the active zone (AZ) component Bruchpilot (Brp), both of which Syd-1 binds directly. We show that a mutant form of Syd-1 that specifically lacks GAP activity localizes normally to presynaptic sites and is sufficient to recruit Nrx-1 but fails to cluster Brp normally. We provide evidence that Syd-1 participates with Rac1 in two separate functions: (1) together with the Rac guanine exchange factor (RacGEF) Trio, GAP-active Syd-1 is required to regulate the nucleotide-bound state of Rac1, thereby promoting Brp clustering; and (2) Syd-1, independent of its GAP activity, is required for the recruitment of Nrx-1 to boutons, including the recruitment of Nrx-1 that is promoted by GTP-bound Rac1. We conclude that, contrary to current models, the GAP domain of fly Syd-1 is active and required for presynaptic development; we suggest that the same may be true of vertebrate Syd-1 proteins. In addition, our data provide new molecular insight into the ability of Rac1 to promote presynaptic development." @default.
• W2775261220 created "2017-12-22" @default.
• W2775261220 creator A5004343197 @default.
• W2775261220 creator A5063894492 @default.
• W2775261220 creator A5083834781 @default.
• W2775261220 date "2018-02-01" @default.
• W2775261220 modified "2023-09-27" @default.
• W2775261220 title "<i>Drosophila</i> Syd-1 Has RhoGAP Activity That Is Required for Presynaptic Clustering of Bruchpilot/ELKS but Not Neurexin-1" @default.
• W2775261220 cites W1522344314 @default.
• W2775261220 cites W1915770046 @default.
• W2775261220 cites W1966857451 @default.
• W2775261220 cites W1969837542 @default.
• W2775261220 cites W1971064851 @default.
• W2775261220 cites W1981289239 @default.
• W2775261220 cites W1984491329 @default.
• W2775261220 cites W1997495841 @default.
• W2775261220 cites W1998137552 @default.
• W2775261220 cites W1999369847 @default.
• W2775261220 cites W2001725097 @default.
• W2775261220 cites W2001757975 @default.
• W2775261220 cites W2013895597 @default.
• W2775261220 cites W2015605553 @default.
• W2775261220 cites W2023712554 @default.
• W2775261220 cites W2027919192 @default.
• W2775261220 cites W2030930681 @default.
• W2775261220 cites W2031075742 @default.
• W2775261220 cites W2048743675 @default.
• W2775261220 cites W2076316109 @default.
• W2775261220 cites W2092171405 @default.
• W2775261220 cites W2095053938 @default.
• W2775261220 cites W2095289526 @default.
• W2775261220 cites W2099202981 @default.
• W2775261220 cites W2102548112 @default.
• W2775261220 cites W2115326787 @default.
• W2775261220 cites W2120613121 @default.
• W2775261220 cites W2139416221 @default.
• W2775261220 cites W2146473598 @default.
• W2775261220 cites W2153954651 @default.
• W2775261220 cites W2158297342 @default.
• W2775261220 cites W2165554927 @default.
• W2775261220 cites W2167279371 @default.
• W2775261220 cites W2167362354 @default.
• W2775261220 cites W2344307126 @default.
• W2775261220 cites W81769958 @default.
• W2775261220 doi "https://doi.org/10.1534/genetics.117.300538" @default.
• W2775261220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5788532" @default.
• W2775261220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29217522" @default.
• W2775261220 hasPublicationYear "2018" @default.
• W2775261220 type Work @default.
• W2775261220 sameAs 2775261220 @default.
• W2775261220 citedByCount "12" @default.
• W2775261220 countsByYear W27752612202018 @default.
• W2775261220 countsByYear W27752612202019 @default.
• W2775261220 countsByYear W27752612202020 @default.
• W2775261220 countsByYear W27752612202021 @default.
• W2775261220 countsByYear W27752612202022 @default.
• W2775261220 countsByYear W27752612202023 @default.
• W2775261220 crossrefType "journal-article" @default.
• W2775261220 hasAuthorship W2775261220A5004343197 @default.
• W2775261220 hasAuthorship W2775261220A5063894492 @default.
• W2775261220 hasAuthorship W2775261220A5083834781 @default.
• W2775261220 hasBestOaLocation W27752612201 @default.
• W2775261220 hasConcept C104317684 @default.
• W2775261220 hasConcept C126619667 @default.
• W2775261220 hasConcept C143065580 @default.
• W2775261220 hasConcept C163181125 @default.
• W2775261220 hasConcept C170493617 @default.
• W2775261220 hasConcept C197341189 @default.
• W2775261220 hasConcept C207332259 @default.
• W2775261220 hasConcept C2778162979 @default.
• W2775261220 hasConcept C2778944004 @default.
• W2775261220 hasConcept C2780104201 @default.
• W2775261220 hasConcept C54355233 @default.
• W2775261220 hasConcept C62478195 @default.
• W2775261220 hasConcept C80631254 @default.
• W2775261220 hasConcept C86803240 @default.
• W2775261220 hasConcept C95444343 @default.
• W2775261220 hasConceptScore W2775261220C104317684 @default.
• W2775261220 hasConceptScore W2775261220C126619667 @default.
• W2775261220 hasConceptScore W2775261220C143065580 @default.
• W2775261220 hasConceptScore W2775261220C163181125 @default.
• W2775261220 hasConceptScore W2775261220C170493617 @default.
• W2775261220 hasConceptScore W2775261220C197341189 @default.
• W2775261220 hasConceptScore W2775261220C207332259 @default.
• W2775261220 hasConceptScore W2775261220C2778162979 @default.
• W2775261220 hasConceptScore W2775261220C2778944004 @default.
• W2775261220 hasConceptScore W2775261220C2780104201 @default.
• W2775261220 hasConceptScore W2775261220C54355233 @default.
• W2775261220 hasConceptScore W2775261220C62478195 @default.
• W2775261220 hasConceptScore W2775261220C80631254 @default.
• W2775261220 hasConceptScore W2775261220C86803240 @default.
• W2775261220 hasConceptScore W2775261220C95444343 @default.
• W2775261220 hasIssue "2" @default.
• W2775261220 hasLocation W27752612201 @default.
• W2775261220 hasLocation W27752612202 @default.
• W2775261220 hasLocation W27752612203 @default.
• W2775261220 hasLocation W27752612204 @default.
• W2775261220 hasOpenAccess W2775261220 @default.

• next