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• W2775268987 abstract "The molecular and cellular etiology of eosinophilic esophagitis (EoE), an emerging tissue-specific allergic disease, involves dysregulated gene expression in esophageal epithelial cells. Herein, we assessed the esophageal expression of IL-33, an epithelium-derived alarmin cytokine, in patients with EoE. IL-33 protein was markedly overexpressed within the nuclei of a subpopulation of basal layer esophageal epithelial cells in patients with active EoE compared to control individuals. IL-33 exhibited dynamic expression as levels normalized upon EoE remission. IL-33-positive basal epithelial cells expressed E-cadherin and the undifferentiated epithelial cell markers keratin 5 and 14 but not the differentiation marker keratin 4. Moreover, the IL-33-positive epithelial cells expressed the epithelial progenitor markers p75 and p63 and lacked the proliferation markers Ki67 and phospho-histone H3. Additionally, the IL-33-positive cells had low expression of PCNA. IL-33 expression was detected in ex vivo-cultured primary esophageal epithelial cells in a subpopulation of cells lacking expression of proliferation markers. Collectively, we report that IL-33 expression is induced in an undifferentiated, non-dividing esophageal epithelial cell population in patients with active EoE." @default.
• W2775268987 created "2017-12-22" @default.
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• W2775268987 date "2017-12-01" @default.
• W2775268987 modified "2023-10-15" @default.
• W2775268987 title "IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis" @default.
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• W2775268987 doi "https://doi.org/10.1038/s41598-017-17541-5" @default.
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• W2775268987 hasPublicationYear "2017" @default.
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