Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775277645> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2775277645 endingPage "373" @default.
- W2775277645 startingPage "340" @default.
- W2775277645 abstract "This chapter sums up the different approaches to harness the promising therapeutic potential of cyclic peptides in drug discovery and proposes a number of areas which need improvement in order to make cyclic peptides live up to their full potential as drug candidates. It is clear that improved methods to rapidly and efficiently synthesize cyclic peptides and modify them are essential to explore this region of chemical space. A better understanding of what governs the physicochemical characteristics of this compound class is essential to allow the better prediction of the properties of designed cyclic peptides. With this goes the ability to accurately and reliably predict the solution and binding conformations of cyclic peptides, as well as theoretical approaches for determining which peptides are likely to cyclize easily, and which are not. How such compounds bind to their target proteins is just beginning to be understood and improvements are necessary to allow the design of cyclic peptides that bind specifically to extended binding sites. Finally, the ability to utilize biosynthetic machineries from diverse pathways to create hybrid molecules with desirable characteristics is proposed as a major target for future investigation." @default.
- W2775277645 created "2017-12-22" @default.
- W2775277645 creator A5011231225 @default.
- W2775277645 creator A5022487493 @default.
- W2775277645 creator A5025482663 @default.
- W2775277645 creator A5031692113 @default.
- W2775277645 creator A5046500929 @default.
- W2775277645 creator A5077765897 @default.
- W2775277645 creator A5082621779 @default.
- W2775277645 date "2017-12-14" @default.
- W2775277645 modified "2023-09-23" @default.
- W2775277645 title "CHAPTER 15. Cyclic Peptides – A Look to the Future" @default.
- W2775277645 doi "https://doi.org/10.1039/9781788010153-00340" @default.
- W2775277645 hasPublicationYear "2017" @default.
- W2775277645 type Work @default.
- W2775277645 sameAs 2775277645 @default.
- W2775277645 citedByCount "0" @default.
- W2775277645 crossrefType "book-chapter" @default.
- W2775277645 hasAuthorship W2775277645A5011231225 @default.
- W2775277645 hasAuthorship W2775277645A5022487493 @default.
- W2775277645 hasAuthorship W2775277645A5025482663 @default.
- W2775277645 hasAuthorship W2775277645A5031692113 @default.
- W2775277645 hasAuthorship W2775277645A5046500929 @default.
- W2775277645 hasAuthorship W2775277645A5077765897 @default.
- W2775277645 hasAuthorship W2775277645A5082621779 @default.
- W2775277645 hasConcept C185592680 @default.
- W2775277645 hasConcept C21951064 @default.
- W2775277645 hasConcept C2779281246 @default.
- W2775277645 hasConcept C41008148 @default.
- W2775277645 hasConcept C55493867 @default.
- W2775277645 hasConcept C60984968 @default.
- W2775277645 hasConcept C70721500 @default.
- W2775277645 hasConcept C74187038 @default.
- W2775277645 hasConcept C86803240 @default.
- W2775277645 hasConcept C99726746 @default.
- W2775277645 hasConceptScore W2775277645C185592680 @default.
- W2775277645 hasConceptScore W2775277645C21951064 @default.
- W2775277645 hasConceptScore W2775277645C2779281246 @default.
- W2775277645 hasConceptScore W2775277645C41008148 @default.
- W2775277645 hasConceptScore W2775277645C55493867 @default.
- W2775277645 hasConceptScore W2775277645C60984968 @default.
- W2775277645 hasConceptScore W2775277645C70721500 @default.
- W2775277645 hasConceptScore W2775277645C74187038 @default.
- W2775277645 hasConceptScore W2775277645C86803240 @default.
- W2775277645 hasConceptScore W2775277645C99726746 @default.
- W2775277645 hasLocation W27752776451 @default.
- W2775277645 hasOpenAccess W2775277645 @default.
- W2775277645 hasPrimaryLocation W27752776451 @default.
- W2775277645 hasRelatedWork W1590002701 @default.
- W2775277645 hasRelatedWork W1871933888 @default.
- W2775277645 hasRelatedWork W1971035066 @default.
- W2775277645 hasRelatedWork W2026693191 @default.
- W2775277645 hasRelatedWork W2041158204 @default.
- W2775277645 hasRelatedWork W2109550123 @default.
- W2775277645 hasRelatedWork W2152384320 @default.
- W2775277645 hasRelatedWork W2189619059 @default.
- W2775277645 hasRelatedWork W2190758858 @default.
- W2775277645 hasRelatedWork W2289687010 @default.
- W2775277645 hasRelatedWork W2415671741 @default.
- W2775277645 hasRelatedWork W2583181571 @default.
- W2775277645 hasRelatedWork W2774958123 @default.
- W2775277645 hasRelatedWork W2790073262 @default.
- W2775277645 hasRelatedWork W2922309461 @default.
- W2775277645 hasRelatedWork W2947634971 @default.
- W2775277645 hasRelatedWork W3014495148 @default.
- W2775277645 hasRelatedWork W3123787127 @default.
- W2775277645 hasRelatedWork W3161940697 @default.
- W2775277645 hasRelatedWork W961440786 @default.
- W2775277645 isParatext "false" @default.
- W2775277645 isRetracted "false" @default.
- W2775277645 magId "2775277645" @default.
- W2775277645 workType "book-chapter" @default.