FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775289944> ?p ?o ?g. }

• W2775289944 endingPage "1118" @default.
• W2775289944 startingPage "1104" @default.
• W2775289944 abstract "<b><i>Background/Aims:</i></b> Renal injuries induced by increased intra-glomerular pressure coincide with podocyte detachment from the glomerular basement membrane (GBM). In previous studies, it was demonstrated that mesangial cells have a crucial role in the pathogenesis of malignant hypertension. However, the exact pathophysiological cascade responsible for podocyte detachment and its relationship with mesangial cells has not been fully elucidated yet and this was the aim of the current study. <b><i>Methods:</i></b> Rat renal mesangial or podocytes were exposed to high hydrostatic pressure in an in-vitro model of malignant hypertension. The resulted effects on podocyte detachment, apoptosis and expression of podocin and integrinβ₁ in addition to Angiotensin-II and TGF-β1 generation were evaluated. To simulate the paracrine effect podocytes were placed in mesangial cell media pre-exposed to pressure, or in media enriched with Angiotensin-II, TGF-β1 or receptor blockers. <b><i>Results:</i></b> High pressure resulted in increased Angiotensin-II levels in mesangial and podocyte cells. Angiotensin-II via the AT1 receptors reduced podocin expression and integrinβ₁, culminating in detachment of both viable and apoptotic podocytes. Mesangial cells exposed to pressure had a greater increase in Angiotensin-II than pressure-exposed podocytes. The massively increased concentration of Angiotensin-II by mesangial cells, together with increased TGF-β1 production, resulted in increased apoptosis and detachment of non-viable apoptotic podocytes. Unlike the direct effect of pressure on podocytes, the mesangial mediated effects were not related to changes in adhesion proteins expression. <b><i>Conclusions:</i></b> Hypertension induces podocyte detachment by autocrine and paracrine effects. In a direct response to pressure, podocytes increase Angiotensin-II levels. This leads, via AT1 receptors, to structural changes in adhesion proteins, culminating in viable podocyte detachment. Paracrine effects of hypertension, mediated by mesangial cells, lead to higher levels of both Angiotensin-II and TGF-β1, culminating in apoptosis and detachment of non-viable podocytes." @default.
• W2775289944 created "2017-12-22" @default.
• W2775289944 creator A5009821887 @default.
• W2775289944 creator A5013788983 @default.
• W2775289944 creator A5013868157 @default.
• W2775289944 creator A5024180480 @default.
• W2775289944 creator A5038902460 @default.
• W2775289944 creator A5074596426 @default.
• W2775289944 creator A5089025697 @default.
• W2775289944 date "2017-01-01" @default.
• W2775289944 modified "2023-09-23" @default.
• W2775289944 title "Response of Renal Podocytes to Excessive Hydrostatic Pressure: a Pathophysiologic Cascade in a Malignant Hypertension Model" @default.
• W2775289944 cites W1775500372 @default.
• W2775289944 cites W1967337697 @default.
• W2775289944 cites W1969526333 @default.
• W2775289944 cites W1977314871 @default.
• W2775289944 cites W1998740840 @default.
• W2775289944 cites W2004761839 @default.
• W2775289944 cites W2007264192 @default.
• W2775289944 cites W2009127116 @default.
• W2775289944 cites W2024607547 @default.
• W2775289944 cites W2025312434 @default.
• W2775289944 cites W2035627251 @default.
• W2775289944 cites W2054074111 @default.
• W2775289944 cites W2067946831 @default.
• W2775289944 cites W2071525042 @default.
• W2775289944 cites W2072415929 @default.
• W2775289944 cites W2076795501 @default.
• W2775289944 cites W2082287458 @default.
• W2775289944 cites W2085574022 @default.
• W2775289944 cites W2085685480 @default.
• W2775289944 cites W2094848681 @default.
• W2775289944 cites W2107087264 @default.
• W2775289944 cites W2113453524 @default.
• W2775289944 cites W2119104164 @default.
• W2775289944 cites W2121977177 @default.
• W2775289944 cites W2132454291 @default.
• W2775289944 cites W2132803823 @default.
• W2775289944 cites W2132849873 @default.
• W2775289944 cites W2138002856 @default.
• W2775289944 cites W2146473759 @default.
• W2775289944 cites W2153673274 @default.
• W2775289944 cites W2157230648 @default.
• W2775289944 cites W2159099277 @default.
• W2775289944 cites W2160308181 @default.
• W2775289944 cites W2166080653 @default.
• W2775289944 cites W2170933176 @default.
• W2775289944 cites W2278408231 @default.
• W2775289944 cites W2552554514 @default.
• W2775289944 cites W2561353042 @default.
• W2775289944 cites W4239470109 @default.
• W2775289944 cites W4246338228 @default.
• W2775289944 doi "https://doi.org/10.1159/000485774" @default.
• W2775289944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29224013" @default.
• W2775289944 hasPublicationYear "2017" @default.
• W2775289944 type Work @default.
• W2775289944 sameAs 2775289944 @default.
• W2775289944 citedByCount "5" @default.
• W2775289944 countsByYear W27752899442018 @default.
• W2775289944 countsByYear W27752899442019 @default.
• W2775289944 countsByYear W27752899442021 @default.
• W2775289944 countsByYear W27752899442022 @default.
• W2775289944 crossrefType "journal-article" @default.
• W2775289944 hasAuthorship W2775289944A5009821887 @default.
• W2775289944 hasAuthorship W2775289944A5013788983 @default.
• W2775289944 hasAuthorship W2775289944A5013868157 @default.
• W2775289944 hasAuthorship W2775289944A5024180480 @default.
• W2775289944 hasAuthorship W2775289944A5038902460 @default.
• W2775289944 hasAuthorship W2775289944A5074596426 @default.
• W2775289944 hasAuthorship W2775289944A5089025697 @default.
• W2775289944 hasBestOaLocation W27752899441 @default.
• W2775289944 hasConcept C121332964 @default.
• W2775289944 hasConcept C123915805 @default.
• W2775289944 hasConcept C126322002 @default.
• W2775289944 hasConcept C134018914 @default.
• W2775289944 hasConcept C170493617 @default.
• W2775289944 hasConcept C185592680 @default.
• W2775289944 hasConcept C2776115139 @default.
• W2775289944 hasConcept C2776855237 @default.
• W2775289944 hasConcept C2777146197 @default.
• W2775289944 hasConcept C2779131090 @default.
• W2775289944 hasConcept C2779561371 @default.
• W2775289944 hasConcept C2780091579 @default.
• W2775289944 hasConcept C2780368995 @default.
• W2775289944 hasConcept C2908929049 @default.
• W2775289944 hasConcept C2910081258 @default.
• W2775289944 hasConcept C71924100 @default.
• W2775289944 hasConcept C97355855 @default.
• W2775289944 hasConceptScore W2775289944C121332964 @default.
• W2775289944 hasConceptScore W2775289944C123915805 @default.
• W2775289944 hasConceptScore W2775289944C126322002 @default.
• W2775289944 hasConceptScore W2775289944C134018914 @default.
• W2775289944 hasConceptScore W2775289944C170493617 @default.
• W2775289944 hasConceptScore W2775289944C185592680 @default.
• W2775289944 hasConceptScore W2775289944C2776115139 @default.
• W2775289944 hasConceptScore W2775289944C2776855237 @default.
• W2775289944 hasConceptScore W2775289944C2777146197 @default.
• W2775289944 hasConceptScore W2775289944C2779131090 @default.

• next