FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775307498> ?p ?o ?g. }

• W2775307498 endingPage "286" @default.
• W2775307498 startingPage "277" @default.
• W2775307498 abstract "Understanding adaptation to complex environments requires information about how exposure to one selection pressure affects adaptation to others. For bacteria, antibiotics and viral parasites (phages) are two of the most common selection pressures and are both relevant for treatment of bacterial infections: increasing antibiotic resistance is generating significant interest in using phages in addition or as an alternative to antibiotics. However, we lack knowledge of how exposure to antibiotics affects bacterial responses to phages. Specifically, it is unclear how the negative effects of antibiotics on bacterial population growth combine with any possible mutagenic effects or physiological responses to influence adaptation to other stressors such as phages, and how this net effect varies with antibiotic concentration. Here, we experimentally addressed the effect of pre-exposure to a wide range of antibiotic concentrations on bacterial responses to phages. Across 10 antibiotics, we found a strong association between their effects on bacterial population size and subsequent population growth in the presence of phages (which in these conditions indicates phage-resistance evolution). We detected some evidence of mutagenesis among populations treated with fluoroquinolones and β-lactams at sublethal doses, but these effects were small and not consistent across phage treatments. These results show that, although stressors such as antibiotics can boost adaptation to other stressors at low concentrations, these effects are weak compared to the effect of reduced population growth at inhibitory concentrations, which in our experiments strongly reduced the likelihood of subsequent phage-resistance evolution." @default.
• W2775307498 created "2017-12-22" @default.
• W2775307498 creator A5020511113 @default.
• W2775307498 creator A5034650378 @default.
• W2775307498 creator A5046531730 @default.
• W2775307498 date "2018-01-02" @default.
• W2775307498 modified "2023-10-12" @default.
• W2775307498 title "Effects of prior exposure to antibiotics on bacterial adaptation to phages" @default.
• W2775307498 cites W1504453842 @default.
• W2775307498 cites W1552724685 @default.
• W2775307498 cites W1573761949 @default.
• W2775307498 cites W1969867718 @default.
• W2775307498 cites W1982286661 @default.
• W2775307498 cites W1990816240 @default.
• W2775307498 cites W1992607648 @default.
• W2775307498 cites W1997152162 @default.
• W2775307498 cites W1999271022 @default.
• W2775307498 cites W2004778468 @default.
• W2775307498 cites W2012179517 @default.
• W2775307498 cites W2029926937 @default.
• W2775307498 cites W2036775991 @default.
• W2775307498 cites W2036925580 @default.
• W2775307498 cites W2041367172 @default.
• W2775307498 cites W2043032580 @default.
• W2775307498 cites W2051695178 @default.
• W2775307498 cites W2053906996 @default.
• W2775307498 cites W2055346334 @default.
• W2775307498 cites W2058236414 @default.
• W2775307498 cites W2061588529 @default.
• W2775307498 cites W2076505260 @default.
• W2775307498 cites W2095833414 @default.
• W2775307498 cites W2096369133 @default.
• W2775307498 cites W2116613551 @default.
• W2775307498 cites W2116726603 @default.
• W2775307498 cites W2125787478 @default.
• W2775307498 cites W2128912763 @default.
• W2775307498 cites W2130785206 @default.
• W2775307498 cites W2146481325 @default.
• W2775307498 cites W2148323109 @default.
• W2775307498 cites W2150975376 @default.
• W2775307498 cites W2249033431 @default.
• W2775307498 cites W2274519180 @default.
• W2775307498 cites W2325428500 @default.
• W2775307498 cites W2337745053 @default.
• W2775307498 cites W2397302711 @default.
• W2775307498 cites W2416484602 @default.
• W2775307498 cites W2466194468 @default.
• W2775307498 cites W2500977754 @default.
• W2775307498 cites W2503624302 @default.
• W2775307498 cites W2510796323 @default.
• W2775307498 cites W2560237604 @default.
• W2775307498 cites W2597347612 @default.
• W2775307498 cites W2622934429 @default.
• W2775307498 cites W2766486207 @default.
• W2775307498 cites W4213353716 @default.
• W2775307498 doi "https://doi.org/10.1111/jeb.13220" @default.
• W2775307498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29218855" @default.
• W2775307498 hasPublicationYear "2018" @default.
• W2775307498 type Work @default.
• W2775307498 sameAs 2775307498 @default.
• W2775307498 citedByCount "2" @default.
• W2775307498 countsByYear W27753074982018 @default.
• W2775307498 crossrefType "journal-article" @default.
• W2775307498 hasAuthorship W2775307498A5020511113 @default.
• W2775307498 hasAuthorship W2775307498A5034650378 @default.
• W2775307498 hasAuthorship W2775307498A5046531730 @default.
• W2775307498 hasBestOaLocation W27753074981 @default.
• W2775307498 hasConcept C104317684 @default.
• W2775307498 hasConcept C139807058 @default.
• W2775307498 hasConcept C144024400 @default.
• W2775307498 hasConcept C149923435 @default.
• W2775307498 hasConcept C169760540 @default.
• W2775307498 hasConcept C2776441376 @default.
• W2775307498 hasConcept C2908647359 @default.
• W2775307498 hasConcept C501593827 @default.
• W2775307498 hasConcept C523546767 @default.
• W2775307498 hasConcept C54355233 @default.
• W2775307498 hasConcept C547475151 @default.
• W2775307498 hasConcept C86803240 @default.
• W2775307498 hasConcept C87590526 @default.
• W2775307498 hasConcept C89423630 @default.
• W2775307498 hasConcept C94665300 @default.
• W2775307498 hasConceptScore W2775307498C104317684 @default.
• W2775307498 hasConceptScore W2775307498C139807058 @default.
• W2775307498 hasConceptScore W2775307498C144024400 @default.
• W2775307498 hasConceptScore W2775307498C149923435 @default.
• W2775307498 hasConceptScore W2775307498C169760540 @default.
• W2775307498 hasConceptScore W2775307498C2776441376 @default.
• W2775307498 hasConceptScore W2775307498C2908647359 @default.
• W2775307498 hasConceptScore W2775307498C501593827 @default.
• W2775307498 hasConceptScore W2775307498C523546767 @default.
• W2775307498 hasConceptScore W2775307498C54355233 @default.
• W2775307498 hasConceptScore W2775307498C547475151 @default.
• W2775307498 hasConceptScore W2775307498C86803240 @default.
• W2775307498 hasConceptScore W2775307498C87590526 @default.
• W2775307498 hasConceptScore W2775307498C89423630 @default.
• W2775307498 hasConceptScore W2775307498C94665300 @default.
• W2775307498 hasFunder F4320320924 @default.

• next