Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775315035> ?p ?o ?g. }
- W2775315035 endingPage "171" @default.
- W2775315035 startingPage "162" @default.
- W2775315035 abstract "Glycogen storage disease type Ib ( GSD ‐Ib) is caused by mutations of the glucose‐6‐phosphate transporter (G6 PT ) and characterized by disrupted glucose homeostasis, neutropenia, and neutrophil dysfunction. To investigate the role of G6 PT in human adipose‐derived mesenchymal stem cells ( hMSC s), the G6 PT gene was mutated by CRISPR /Cas9 technology and single cell‐derived G6 PT −/− hMSC s were established. G6 PT −/− hMSC s have significantly increased cell proliferation but impaired adipogenesis and osteogenesis. These phenotypes are associated with two mechanisms: i) metabolic reprogramming in G6 PT −/− hMSC s causing a metabolic shift toward glycolysis rather than oxidative phosphorylation and ii) increased cyclooxygenase‐2‐derived prostaglandin E 2 secretion in G6 PT −/− hMSC s. This study demonstrates that G6 PT is essential for proliferation and differentiation of MSC s, providing important insights into the GSD ‐Ib phenotypes." @default.
- W2775315035 created "2017-12-22" @default.
- W2775315035 creator A5016661138 @default.
- W2775315035 creator A5023129203 @default.
- W2775315035 creator A5032479296 @default.
- W2775315035 creator A5050694512 @default.
- W2775315035 creator A5058451474 @default.
- W2775315035 creator A5084283705 @default.
- W2775315035 creator A5085299255 @default.
- W2775315035 date "2018-01-01" @default.
- W2775315035 modified "2023-10-13" @default.
- W2775315035 title "Aberrant proliferation and differentiation of glycogen storage disease type Ib mesenchymal stem cells" @default.
- W2775315035 cites W1968094712 @default.
- W2775315035 cites W1975371675 @default.
- W2775315035 cites W1979043688 @default.
- W2775315035 cites W1994386447 @default.
- W2775315035 cites W2018542907 @default.
- W2775315035 cites W2024965515 @default.
- W2775315035 cites W2034872735 @default.
- W2775315035 cites W2035879756 @default.
- W2775315035 cites W2039811582 @default.
- W2775315035 cites W2040426333 @default.
- W2775315035 cites W2051584795 @default.
- W2775315035 cites W2058349560 @default.
- W2775315035 cites W2060984709 @default.
- W2775315035 cites W2062519528 @default.
- W2775315035 cites W2067958598 @default.
- W2775315035 cites W2087880830 @default.
- W2775315035 cites W2125471714 @default.
- W2775315035 cites W2141467894 @default.
- W2775315035 cites W2144268541 @default.
- W2775315035 cites W2151630485 @default.
- W2775315035 cites W2158048826 @default.
- W2775315035 cites W2170620582 @default.
- W2775315035 cites W2407145194 @default.
- W2775315035 cites W2528400389 @default.
- W2775315035 cites W2561810829 @default.
- W2775315035 cites W2611472237 @default.
- W2775315035 doi "https://doi.org/10.1002/1873-3468.12939" @default.
- W2775315035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29238966" @default.
- W2775315035 hasPublicationYear "2018" @default.
- W2775315035 type Work @default.
- W2775315035 sameAs 2775315035 @default.
- W2775315035 citedByCount "8" @default.
- W2775315035 countsByYear W27753150352018 @default.
- W2775315035 countsByYear W27753150352019 @default.
- W2775315035 countsByYear W27753150352020 @default.
- W2775315035 countsByYear W27753150352021 @default.
- W2775315035 countsByYear W27753150352022 @default.
- W2775315035 crossrefType "journal-article" @default.
- W2775315035 hasAuthorship W2775315035A5016661138 @default.
- W2775315035 hasAuthorship W2775315035A5023129203 @default.
- W2775315035 hasAuthorship W2775315035A5032479296 @default.
- W2775315035 hasAuthorship W2775315035A5050694512 @default.
- W2775315035 hasAuthorship W2775315035A5058451474 @default.
- W2775315035 hasAuthorship W2775315035A5084283705 @default.
- W2775315035 hasAuthorship W2775315035A5085299255 @default.
- W2775315035 hasBestOaLocation W27753150351 @default.
- W2775315035 hasConcept C104317684 @default.
- W2775315035 hasConcept C122927707 @default.
- W2775315035 hasConcept C134018914 @default.
- W2775315035 hasConcept C148738053 @default.
- W2775315035 hasConcept C1491633281 @default.
- W2775315035 hasConcept C185592680 @default.
- W2775315035 hasConcept C198826908 @default.
- W2775315035 hasConcept C2777499176 @default.
- W2775315035 hasConcept C2779018223 @default.
- W2775315035 hasConcept C2779468605 @default.
- W2775315035 hasConcept C28328180 @default.
- W2775315035 hasConcept C502942594 @default.
- W2775315035 hasConcept C55493867 @default.
- W2775315035 hasConcept C77255625 @default.
- W2775315035 hasConcept C86803240 @default.
- W2775315035 hasConcept C95444343 @default.
- W2775315035 hasConceptScore W2775315035C104317684 @default.
- W2775315035 hasConceptScore W2775315035C122927707 @default.
- W2775315035 hasConceptScore W2775315035C134018914 @default.
- W2775315035 hasConceptScore W2775315035C148738053 @default.
- W2775315035 hasConceptScore W2775315035C1491633281 @default.
- W2775315035 hasConceptScore W2775315035C185592680 @default.
- W2775315035 hasConceptScore W2775315035C198826908 @default.
- W2775315035 hasConceptScore W2775315035C2777499176 @default.
- W2775315035 hasConceptScore W2775315035C2779018223 @default.
- W2775315035 hasConceptScore W2775315035C2779468605 @default.
- W2775315035 hasConceptScore W2775315035C28328180 @default.
- W2775315035 hasConceptScore W2775315035C502942594 @default.
- W2775315035 hasConceptScore W2775315035C55493867 @default.
- W2775315035 hasConceptScore W2775315035C77255625 @default.
- W2775315035 hasConceptScore W2775315035C86803240 @default.
- W2775315035 hasConceptScore W2775315035C95444343 @default.
- W2775315035 hasFunder F4320310017 @default.
- W2775315035 hasFunder F4320321408 @default.
- W2775315035 hasFunder F4320322035 @default.
- W2775315035 hasIssue "2" @default.
- W2775315035 hasLocation W27753150351 @default.
- W2775315035 hasLocation W27753150352 @default.
- W2775315035 hasOpenAccess W2775315035 @default.
- W2775315035 hasPrimaryLocation W27753150351 @default.