FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775331525> ?p ?o ?g. }

• W2775331525 endingPage "2130" @default.
• W2775331525 startingPage "2130" @default.
• W2775331525 abstract "Excessive microglial stimulation has been recognized in several neurodegenerative diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), amyotropic lateral sclerosis (ALS), HIV-associated dementia (HAD), multiple sclerosis (MS), and stroke. When microglia are stimulated, they produce proinflammatory mediators and cytokines, including nitric oxide (NO) derived from inducible NO synthase (iNOS), prostaglandin E2 (PGE₂) derived from cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-12 (IL-12), and interleukin-6 (IL-6). These inflammatory reactions are related to the nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Therefore, the modulation of NF-κB and MAPK is vital to prevent microglial activation and confer resistance against neuronal injury. In this study, steppogenin (1) isolated from Cudrania tricuspidata suppressed the neuroinflammatory responses to lipopolysaccharide (LPS). Steppogenin (1) inhibited the production of proinflammatory mediators and cytokines in LPS-challenged BV2 and rat primary microglial cells. Moreover, western blot analysis and immunofluorescence revealed that the nuclear translocation of NF-κB was inhibited in LPS-induced BV2 and rat primary microglial cells. The LPS-stimulated activation of BV2 and rat primary microglial cells was inhibited by steppogenin (1) through the suppression of c-Jun NH2-terminal kinase (JNK) and p38 MAPK signaling. These results suggested that steppogenin (1) exerted antineuroinflammatory effects against acute neuroinflammation in BV2 and rat primary microglial cells by suppressing the activation of NF-κB and MAPK signaling and the production of proinflammatory mediators and cytokines." @default.
• W2775331525 created "2017-12-22" @default.
• W2775331525 creator A5027332315 @default.
• W2775331525 creator A5053927454 @default.
• W2775331525 creator A5072802613 @default.
• W2775331525 creator A5079957929 @default.
• W2775331525 date "2017-12-02" @default.
• W2775331525 modified "2023-10-18" @default.
• W2775331525 title "Steppogenin Isolated from Cudrania tricuspidata Shows Antineuroinflammatory Effects via NF-κB and MAPK Pathways in LPS-Stimulated BV2 and Primary Rat Microglial Cells" @default.
• W2775331525 cites W1520123863 @default.
• W2775331525 cites W1846394712 @default.
• W2775331525 cites W1970226136 @default.
• W2775331525 cites W1980728700 @default.
• W2775331525 cites W1983644298 @default.
• W2775331525 cites W1984909355 @default.
• W2775331525 cites W1987264412 @default.
• W2775331525 cites W2000251959 @default.
• W2775331525 cites W2008708162 @default.
• W2775331525 cites W2011361113 @default.
• W2775331525 cites W2015445169 @default.
• W2775331525 cites W2018863164 @default.
• W2775331525 cites W2020732748 @default.
• W2775331525 cites W2026032500 @default.
• W2775331525 cites W2030606505 @default.
• W2775331525 cites W2032830665 @default.
• W2775331525 cites W2034831207 @default.
• W2775331525 cites W2041272087 @default.
• W2775331525 cites W2046753209 @default.
• W2775331525 cites W2060600148 @default.
• W2775331525 cites W2071199990 @default.
• W2775331525 cites W2081599133 @default.
• W2775331525 cites W2082414904 @default.
• W2775331525 cites W2126676163 @default.
• W2775331525 cites W2148556164 @default.
• W2775331525 cites W2149538964 @default.
• W2775331525 cites W2151283331 @default.
• W2775331525 cites W2162935886 @default.
• W2775331525 cites W2164594351 @default.
• W2775331525 cites W2173846903 @default.
• W2775331525 cites W2233621979 @default.
• W2775331525 cites W2259788439 @default.
• W2775331525 cites W2274499993 @default.
• W2775331525 cites W2293717233 @default.
• W2775331525 cites W2323088595 @default.
• W2775331525 cites W2531949738 @default.
• W2775331525 cites W333643404 @default.
• W2775331525 cites W4210970457 @default.
• W2775331525 doi "https://doi.org/10.3390/molecules22122130" @default.
• W2775331525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6149939" @default.
• W2775331525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29207498" @default.
• W2775331525 hasPublicationYear "2017" @default.
• W2775331525 type Work @default.
• W2775331525 sameAs 2775331525 @default.
• W2775331525 citedByCount "36" @default.
• W2775331525 countsByYear W27753315252018 @default.
• W2775331525 countsByYear W27753315252019 @default.
• W2775331525 countsByYear W27753315252020 @default.
• W2775331525 countsByYear W27753315252021 @default.
• W2775331525 countsByYear W27753315252022 @default.
• W2775331525 countsByYear W27753315252023 @default.
• W2775331525 crossrefType "journal-article" @default.
• W2775331525 hasAuthorship W2775331525A5027332315 @default.
• W2775331525 hasAuthorship W2775331525A5053927454 @default.
• W2775331525 hasAuthorship W2775331525A5072802613 @default.
• W2775331525 hasAuthorship W2775331525A5079957929 @default.
• W2775331525 hasBestOaLocation W27753315251 @default.
• W2775331525 hasConcept C134018914 @default.
• W2775331525 hasConcept C164027704 @default.
• W2775331525 hasConcept C17991360 @default.
• W2775331525 hasConcept C185592680 @default.
• W2775331525 hasConcept C203014093 @default.
• W2775331525 hasConcept C2776914184 @default.
• W2775331525 hasConcept C2777622882 @default.
• W2775331525 hasConcept C2777730290 @default.
• W2775331525 hasConcept C2779830541 @default.
• W2775331525 hasConcept C51551487 @default.
• W2775331525 hasConcept C519581460 @default.
• W2775331525 hasConcept C57074206 @default.
• W2775331525 hasConcept C62478195 @default.
• W2775331525 hasConcept C86803240 @default.
• W2775331525 hasConcept C87753298 @default.
• W2775331525 hasConcept C95444343 @default.
• W2775331525 hasConceptScore W2775331525C134018914 @default.
• W2775331525 hasConceptScore W2775331525C164027704 @default.
• W2775331525 hasConceptScore W2775331525C17991360 @default.
• W2775331525 hasConceptScore W2775331525C185592680 @default.
• W2775331525 hasConceptScore W2775331525C203014093 @default.
• W2775331525 hasConceptScore W2775331525C2776914184 @default.
• W2775331525 hasConceptScore W2775331525C2777622882 @default.
• W2775331525 hasConceptScore W2775331525C2777730290 @default.
• W2775331525 hasConceptScore W2775331525C2779830541 @default.
• W2775331525 hasConceptScore W2775331525C51551487 @default.
• W2775331525 hasConceptScore W2775331525C519581460 @default.
• W2775331525 hasConceptScore W2775331525C57074206 @default.
• W2775331525 hasConceptScore W2775331525C62478195 @default.
• W2775331525 hasConceptScore W2775331525C86803240 @default.
• W2775331525 hasConceptScore W2775331525C87753298 @default.
• W2775331525 hasConceptScore W2775331525C95444343 @default.

• next