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• W2775361777 abstract "Background: There is a paucity of data on risk factors associated with significant proteinuria in kidney transplant recipients. Hence, we carried out this study to examine the independent risk factors for significant proteinuria in kidney transplant recipients who received kidneys from living donors. We also aimed at studying the allograft biopsy spectrum of these patients. Methods: We screened 300 adult ( ≥18 years age) kidney transplant recipients from living donors for significant proteinuria. Patients who satisfied the criteria of significant proteinuria were categorized as group I and those who did not have significant proteinuria were categorized as group II. The clinical, demographic and various laboratory variables were compared between the two groups by uni and multivariate analysis. We performed allograft biopsy in those patients who had significant proteinuria (Group I) and classified them based on their histological characteristics. The allograft pathology was defined according to the Banff 2009 update. Results: Reccurent/Denovo glomerular disease was the most common allograft pathology (51.5% of all allograft biopsies). On multivariate analysis the variables independently associated with significant proteinuria were - male recipient ( OR 2.73; C.I: 1.05 - 7.1), new onset diabetes after transplant (NODAT) ( Absence of NODAT is protective - OR 0.5, C.I: 0.3 - 1.1), history of acute cellular rejection (OR 2.8, C.I: 1.2 - 6.6), history of antibody mediated rejection, recipient age more than 50. Conclusions 1. Male recipients, patients with new onset diabetes after transplant, high recipient age, acute cellular and antibody mediated rejections and high recipient age are independent risk factors for proteinuria among renal transplant recipients who receive kidney from living donors. Hence, these group of patients need to be screened more frequently for proteinuria. 2. Reccurent/Denovo glomerular disease is the most common glomerular pathology in post renal transplant patients with significant proteinuria" @default.
• W2775361777 created "2017-12-22" @default.
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• W2775361777 date "2014-07-01" @default.
• W2775361777 modified "2023-09-23" @default.
• W2775361777 title "Significant Proteinuria in Post Renal Transplant Recipients Who Received Kidney From Living Donors: Analysis of Risk Factors and Study of Allograft Histopathology." @default.
• W2775361777 doi "https://doi.org/10.1097/00007890-201407151-01898" @default.
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