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- W2775365478 abstract "Epithelia are layers of polarised cells tightly bound to each other by adhesive contacts. Epithelia act as barriers between an organism and its external environment. Understanding how epithelia maintain their essential integrity while remaining sufficiently plastic to allow events such as cytokinesis to take place is a key biological problem. In vertebrates, the remodelling and reinforcement of adherens junctions maintains epithelial integrity during cytokinesis. The involvement of tight junctions in cell division, however, has remained unexplored. Here, we examine the role of tight junctions during cytokinesis in the epithelium of the Xenopus laevis embryo. Depletion of tight junction-associated proteins ZO-1 and GEF-H1 leads to altered cytokinesis duration and contractile ring geometry. Using a tension biosensor, we show that cytokinesis defects originate from misregulation of tensile forces applied to adherens junctions. Our results reveal that tight junctions regulate mechanical tension applied to adherens junctions, which in turn impacts cytokinesis." @default.
- W2775365478 created "2017-12-22" @default.
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- W2775365478 date "2017-01-01" @default.
- W2775365478 modified "2023-10-16" @default.
- W2775365478 title "Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue" @default.
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- W2775365478 doi "https://doi.org/10.1242/jcs.208736" @default.
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