FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775365517> ?p ?o ?g. }

• W2775365517 abstract "Abstract Study Objectives Excessive sleepiness is a common symptom in Prader–Willi syndrome (PWS), and it negatively impacts the quality of life. Obstructive sleep apnea and narcolepsy phenotypes have been reported in PWS. We characterized sleep disorders in a large cohort of adults with PWS. Methods All consecutive patients with genetically confirmed PWS unselected for sleep-related symptoms, underwent a clinical interview, polysomnography, and multiple sleep latency tests (MSLT, n = 60), followed by long-term (24 hours) polysomnography (n = 22/60). Results Among 60 adults evaluated (57% female, aged 25 ± 10 years, body mass index: 39 ± 12 kg/m2), 67% reported excessive sleepiness. According to the sleep study results, 43% had a previously unrecognized hypersomnia disorder, 15% had an isolated sleep breathing disorder, 12% had combined hypersomnia disorder and untreated breathing sleep disorder, and only 30% had normal sleep. Isolated hypersomnia disorder included narcolepsy in 35% (type 1, n = 1, and type 2, n = 8), hypersomnia in 12% (total sleep time &gt;11 hours, n = 2, and MSLT &lt;8 minutes, n = 1), and borderline phenotype in 53% (≥2 sleep onset in REM periods and MSLT &gt;8 minutes, n = 10, and 8 minutes &lt; MSLT &lt; 10 minutes, n = 4). Sleep breathing disorders, isolated and combined, included obstructive sleep apnea (n = 14, already treated in seven), sleep hypoxemia (n = 1) and previously undiagnosed hypoventilation (n = 5). Modafinil was taken by 16 patients (well tolerated in 10), resulting in improved sleepiness over a mean 5-year follow-up period. Conclusion Sleepiness affects more than half of adult patients with PWS, with a variety of hypersomnia disorder (narcolepsy, hypersomnia, and borderline phenotypes) and breathing sleep disorders. Earlier diagnosis and management of sleep disorders may improve sleepiness, cognition, and behavior in these patients." @default.
• W2775365517 created "2017-12-22" @default.
• W2775365517 creator A5023850352 @default.
• W2775365517 creator A5042849482 @default.
• W2775365517 creator A5046663017 @default.
• W2775365517 creator A5059730125 @default.
• W2775365517 creator A5069591541 @default.
• W2775365517 creator A5076371474 @default.
• W2775365517 creator A5081884225 @default.
• W2775365517 creator A5083408547 @default.
• W2775365517 date "2017-10-09" @default.
• W2775365517 modified "2023-10-12" @default.
• W2775365517 title "Prevalence and Phenotype of Sleep Disorders in 60 Adults With Prader–Willi Syndrome" @default.
• W2775365517 cites W1922423641 @default.
• W2775365517 cites W1968944348 @default.
• W2775365517 cites W197066864 @default.
• W2775365517 cites W1991965480 @default.
• W2775365517 cites W2000757438 @default.
• W2775365517 cites W2004466637 @default.
• W2775365517 cites W2016192465 @default.
• W2775365517 cites W2016586520 @default.
• W2775365517 cites W2035265275 @default.
• W2775365517 cites W2040722598 @default.
• W2775365517 cites W2042457228 @default.
• W2775365517 cites W2054214377 @default.
• W2775365517 cites W2061039214 @default.
• W2775365517 cites W2072483375 @default.
• W2775365517 cites W2092721169 @default.
• W2775365517 cites W2093240006 @default.
• W2775365517 cites W2104684547 @default.
• W2775365517 cites W2114211541 @default.
• W2775365517 cites W2118779759 @default.
• W2775365517 cites W2125108705 @default.
• W2775365517 cites W2149070866 @default.
• W2775365517 cites W2152890661 @default.
• W2775365517 cites W2264784497 @default.
• W2775365517 cites W2287117136 @default.
• W2775365517 cites W2407435034 @default.
• W2775365517 cites W2409487943 @default.
• W2775365517 cites W4240242196 @default.
• W2775365517 cites W76952702 @default.
• W2775365517 doi "https://doi.org/10.1093/sleep/zsx162" @default.
• W2775365517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29294134" @default.
• W2775365517 hasPublicationYear "2017" @default.
• W2775365517 type Work @default.
• W2775365517 sameAs 2775365517 @default.
• W2775365517 citedByCount "34" @default.
• W2775365517 countsByYear W27753655172017 @default.
• W2775365517 countsByYear W27753655172019 @default.
• W2775365517 countsByYear W27753655172020 @default.
• W2775365517 countsByYear W27753655172021 @default.
• W2775365517 countsByYear W27753655172022 @default.
• W2775365517 countsByYear W27753655172023 @default.
• W2775365517 crossrefType "journal-article" @default.
• W2775365517 hasAuthorship W2775365517A5023850352 @default.
• W2775365517 hasAuthorship W2775365517A5042849482 @default.
• W2775365517 hasAuthorship W2775365517A5046663017 @default.
• W2775365517 hasAuthorship W2775365517A5059730125 @default.
• W2775365517 hasAuthorship W2775365517A5069591541 @default.
• W2775365517 hasAuthorship W2775365517A5076371474 @default.
• W2775365517 hasAuthorship W2775365517A5081884225 @default.
• W2775365517 hasAuthorship W2775365517A5083408547 @default.
• W2775365517 hasBestOaLocation W27753655171 @default.
• W2775365517 hasConcept C118552586 @default.
• W2775365517 hasConcept C126322002 @default.
• W2775365517 hasConcept C1513209611 @default.
• W2775365517 hasConcept C187212893 @default.
• W2775365517 hasConcept C2776006263 @default.
• W2775365517 hasConcept C2777446050 @default.
• W2775365517 hasConcept C2777935920 @default.
• W2775365517 hasConcept C2778205975 @default.
• W2775365517 hasConcept C2778664715 @default.
• W2775365517 hasConcept C2779494582 @default.
• W2775365517 hasConcept C2780714222 @default.
• W2775365517 hasConcept C2781210498 @default.
• W2775365517 hasConcept C2781326671 @default.
• W2775365517 hasConcept C2781433485 @default.
• W2775365517 hasConcept C2781442344 @default.
• W2775365517 hasConcept C42219234 @default.
• W2775365517 hasConcept C71924100 @default.
• W2775365517 hasConceptScore W2775365517C118552586 @default.
• W2775365517 hasConceptScore W2775365517C126322002 @default.
• W2775365517 hasConceptScore W2775365517C1513209611 @default.
• W2775365517 hasConceptScore W2775365517C187212893 @default.
• W2775365517 hasConceptScore W2775365517C2776006263 @default.
• W2775365517 hasConceptScore W2775365517C2777446050 @default.
• W2775365517 hasConceptScore W2775365517C2777935920 @default.
• W2775365517 hasConceptScore W2775365517C2778205975 @default.
• W2775365517 hasConceptScore W2775365517C2778664715 @default.
• W2775365517 hasConceptScore W2775365517C2779494582 @default.
• W2775365517 hasConceptScore W2775365517C2780714222 @default.
• W2775365517 hasConceptScore W2775365517C2781210498 @default.
• W2775365517 hasConceptScore W2775365517C2781326671 @default.
• W2775365517 hasConceptScore W2775365517C2781433485 @default.
• W2775365517 hasConceptScore W2775365517C2781442344 @default.
• W2775365517 hasConceptScore W2775365517C42219234 @default.
• W2775365517 hasConceptScore W2775365517C71924100 @default.
• W2775365517 hasIssue "12" @default.
• W2775365517 hasLocation W27753655171 @default.
• W2775365517 hasLocation W27753655172 @default.

• next