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- W2775365596 abstract "Although the concept of left-hemispheric lateralization of neural processes during speech production has been known since the times of Broca, its physiological underpinnings still remain elusive. We sought to assess the modulatory influences of a major neurotransmitter, dopamine, on hemispheric lateralization during real-life speaking using a multimodal analysis of functional MRI, intracranial EEG recordings, and large-scale neural population simulations based on diffusion-weighted MRI. We demonstrate that speech-induced phasic dopamine release into the dorsal striatum and speech motor cortex exerts direct modulation of neuronal activity in these regions and drives left-hemispheric lateralization of speech production network. Dopamine-induced lateralization of functional activity and networks during speaking is not dependent on lateralization of structural nigro-striatal and nigro-motocortical pathways. Our findings provide the first mechanistic explanation for left-hemispheric lateralization of human speech that is due to left-lateralized dopaminergic modulation of brain activity and functional networks." @default.
- W2775365596 created "2017-12-22" @default.
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- W2775365596 date "2017-12-21" @default.
- W2775365596 modified "2023-10-14" @default.
- W2775365596 title "Dopamine drives left-hemispheric lateralization of neural networks during human speech" @default.
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- W2775365596 doi "https://doi.org/10.1002/cne.24375" @default.
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