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• W2775384618 abstract "Neuromodulation techniques targeting limbic circuits can be used to treat refractory psychiatric or neurological disorders. However, objective measure for the impact of neuromodulation on affective brain circuits lacks. Deep brain stimulation at a key node of the limbic circuit, the anterior thalamic nuclei (ANT-DBS), is used to treat refractory epilepsy. While effective in reducing seizures, patients have reported subjective depressive symptoms as a side effect. In line with potential vulnerability to depression, we have previously shown ANT-DBS to increase attention allocation to threat evidenced by behavior and brain physiology. Rightward frontal alpha asymmetry with greater right hemispheric activation is thought to reflect brain physiology linked with depression and anxiety. To that end, we investigated whether high-frequency electric stimulation at ANT influences frontal alpha asymmetry. Furthermore, we explored the impact of DBS on emotional modulation of frontal alpha asymmetry and whether it is linked with emotional modulation of response speed. Electrical stimulation at ANT led to an increased rightward frontal alpha asymmetry compared to situations where stimulation was off [F (1, 12) = 14.09, p = 0.003] or the thalamic control location was stimulated [F (1, 12) = 10.19, p = 0.008], along with prolonged reaction time in the context of emotional distractors [F (1, 7) = 16.66, p = 0.005]. The change was specifically driven by increased activity in right hemisphere. Furthermore, we found a correlation between the emotional modulation of frontal alpha asymmetry and emotional interference of response speed due to ANT stimulation [r = 0.78, p = 0.02]. In conclusion, DBS at ANT increased relative right hemispheric activity, as was linked with emotional modulation of behavior. Previous studies have linked frontal alpha asymmetry with emotion related symptoms and shown that vagus nerve stimulation modulates alpha asymmetry as well. Thus, in the light of the previous literature and current findings, we suggest that frontal alpha asymmetry with emotional interference of response speed might be a feasible biomarker for the effects of neuromodulation on brain’s affective circuitry in general." @default.
• W2775384618 created "2017-12-22" @default.
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• W2775384618 date "2017-12-04" @default.
• W2775384618 modified "2023-09-23" @default.
• W2775384618 title "Frontal Alpha Asymmetry, a Potential Biomarker for the Effect of Neuromodulation on Brain’s Affective Circuitry—Preliminary Evidence from a Deep Brain Stimulation Study" @default.
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• W2775384618 doi "https://doi.org/10.3389/fnhum.2017.00584" @default.
• W2775384618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5722792" @default.
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• W2775384618 hasPublicationYear "2017" @default.
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