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- W2775409053 endingPage "410" @default.
- W2775409053 startingPage "391" @default.
- W2775409053 abstract "In multiscale structural biology, synthetic approaches are important to demonstrate biophysical principles and mechanisms underlying the structure, function, and action of bio-nanomachines. A central goal of “synthetic structural biology” is the design and construction of artificial proteins and protein complexes as desired. In this paper, I review recent remarkable progress of an array of approaches for hierarchical design of artificial proteins and complexes that signpost the path forward toward synthetic structural biology as an emerging interdisciplinary field. Topics covered include combinatorial and protein-engineering approaches for directed evolution of artificial binding proteins and membrane proteins, binary code strategy for structural and functional de novo proteins, protein nanobuilding block strategy for constructing nano-architectures, protein–metal–organic frameworks for 3D protein complex crystals, and rational and computational approaches for design/creation of artificial proteins and complexes, novel protein folds, ideal/optimized protein structures, novel binding proteins for targeted therapeutics, and self-assembling nanomaterials. Protein designers and engineers look toward a bright future in synthetic structural biology for the next generation of biophysics and biotechnology." @default.
- W2775409053 created "2017-12-22" @default.
- W2775409053 creator A5033527498 @default.
- W2775409053 date "2017-12-14" @default.
- W2775409053 modified "2023-10-16" @default.
- W2775409053 title "Hierarchical design of artificial proteins and complexes toward synthetic structural biology" @default.
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