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• W2775415478 abstract "Silymarin, a plant-derived polyphenolic flavonoid of Silybum marianum, elicited significant antidepressant-like activity in an acute restraint stress model of depression. It improved monoamines, mainly 5-hydroxytryptamine (5-HT) levels in the cortex, dopamine (DA) and norepinephrine (NE) in the cerebellum in mice. The present study was undertaken to explore the antidepressant potential of silymarin in chronic unpredictable mild stress (CUMS) induced depressive-like behavior in mice, and to find out its probable mechanism(s) of action, mainly neurogenesis, neuroinflammation, and/or oxidative stress. The mice were subjected to CUMS for 28 days (4 weeks) and administered with silymarin (100 mg/kg and 200 mg/kg), or fluoxetine or vehicle from days 8 to 28 (3 weeks simultaneously). Animals were evaluated for behavioral changes, such as anhedonia by sucrose preference test, behavioral despair by forced swim test, and exploratory behaviors by an open field test. In addition, neurobiochemical alterations, mainly monoamines, 5-HT, NE, DA, neurotrophic factor BDNF, and cytokines, IL-6, TNF-α, oxidant-antioxidant parameters by determining the malondialdehyde formation (an index of lipid peroxidation process), superoxide dismutase (SOD) and catalase (CAT) activity in hippocampus and cerebral cortex along with serum corticosterone were investigated. Our findings reveal that mice subjected to CUMS exhibited lower sucrose preference, increase immobility time without affecting general locomotion of the animals, and reduce BDNF, 5-HT, NE, and DA level, increased serum corticosterone, IL-6 and TNF-α along with an oxidant-antioxidant imbalance in the hippocampus and cerebral cortex. Silymarin significantly reversed the CUMS-induced changes in the hippocampus and cerebral cortex in mice. Thus, the possible mechanism involved in the antidepressant-like activity of silymarin is correlated to the alleviation of monoaminergic, neurogenesis (enhancing 5-HT, NE, and BDNF levels), and attenuation of inflammatory cytokines system and oxidative stress by modulation of corticosterone response, restoration of antioxidant defense system in cerebral cortex and hippocampus." @default.
• W2775415478 created "2017-12-22" @default.
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• W2775415478 date "2017-12-07" @default.
• W2775415478 modified "2023-09-26" @default.
• W2775415478 title "Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice" @default.
• W2775415478 cites W1516644432 @default.
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• W2775415478 cites W1750690213 @default.
• W2775415478 cites W1769690510 @default.
• W2775415478 cites W191793640 @default.
• W2775415478 cites W1968209165 @default.
• W2775415478 cites W1973652904 @default.
• W2775415478 cites W1973929801 @default.
• W2775415478 cites W1976872778 @default.
• W2775415478 cites W1977430165 @default.
• W2775415478 cites W1980411244 @default.
• W2775415478 cites W1983310681 @default.
• W2775415478 cites W1985438873 @default.
• W2775415478 cites W1985503795 @default.
• W2775415478 cites W1990635740 @default.
• W2775415478 cites W1992030794 @default.
• W2775415478 cites W1993636230 @default.
• W2775415478 cites W1995837298 @default.
• W2775415478 cites W1997906526 @default.
• W2775415478 cites W1998558145 @default.
• W2775415478 cites W2000273941 @default.
• W2775415478 cites W2001646460 @default.
• W2775415478 cites W2003227142 @default.
• W2775415478 cites W2006113912 @default.
• W2775415478 cites W2006370393 @default.
• W2775415478 cites W2014394457 @default.
• W2775415478 cites W2018365274 @default.
• W2775415478 cites W2018743772 @default.
• W2775415478 cites W2023618561 @default.
• W2775415478 cites W2031679669 @default.
• W2775415478 cites W2034654800 @default.
• W2775415478 cites W2037334463 @default.
• W2775415478 cites W2040784119 @default.
• W2775415478 cites W2042267709 @default.
• W2775415478 cites W2046186483 @default.
• W2775415478 cites W2049132241 @default.
• W2775415478 cites W2049361817 @default.
• W2775415478 cites W2050836998 @default.
• W2775415478 cites W2061088962 @default.
• W2775415478 cites W2062989629 @default.
• W2775415478 cites W2064194834 @default.
• W2775415478 cites W2066427182 @default.
• W2775415478 cites W2069270685 @default.
• W2775415478 cites W2077405462 @default.
• W2775415478 cites W2078691062 @default.
• W2775415478 cites W2082464174 @default.
• W2775415478 cites W2083772767 @default.
• W2775415478 cites W2089057825 @default.
• W2775415478 cites W2089202379 @default.
• W2775415478 cites W2092843998 @default.
• W2775415478 cites W2093323105 @default.
• W2775415478 cites W2093752683 @default.
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• W2775415478 doi "https://doi.org/10.1177/0269881117742666" @default.
• W2775415478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29215318" @default.
• W2775415478 hasPublicationYear "2017" @default.
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