FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775443868> ?p ?o ?g. }

• W2775443868 endingPage "864" @default.
• W2775443868 startingPage "853" @default.
• W2775443868 abstract "Abstract Increasing evidence suggests the presence of minor cell subpopulations in prostate cancer that are androgen independent and poised for selection as dominant clones after androgen deprivation therapy. In this study, we investigated this phenomenon by stratifying cell subpopulations based on transcriptome profiling of 144 single LNCaP prostate cancer cells treated or untreated with androgen after cell-cycle synchronization. Model-based clustering of 397 differentially expressed genes identified eight potential subpopulations of LNCaP cells, revealing a previously unappreciable level of cellular heterogeneity to androgen stimulation. One subpopulation displayed stem-like features with a slower cell doubling rate, increased sphere formation capability, and resistance to G2–M arrest induced by a mitosis inhibitor. Advanced growth of this subpopulation was associated with enhanced expression of 10 cell-cycle–related genes (CCNB2, DLGAP5, CENPF, CENPE, MKI67, PTTG1, CDC20, PLK1, HMMR, and CCNB1) and decreased dependence upon androgen receptor signaling. In silico analysis of RNA-seq data from The Cancer Genome Atlas further demonstrated that concordant upregulation of these genes was linked to recurrent prostate cancers. Analysis of receiver operating characteristic curves implicates aberrant expression of these genes and could be useful for early identification of tumors that subsequently develop biochemical recurrence. Moreover, this single-cell approach provides a better understanding of how prostate cancer cells respond heterogeneously to androgen deprivation therapies and reveals characteristics of subpopulations resistant to this treatment. Significance: Illustrating the challenge in treating cancers with targeted drugs, which by selecting for drug resistance can drive metastatic progression, this study characterized the plasticity and heterogeneity of prostate cancer cells with regard to androgen dependence, defining the character or minor subpopulations of androgen-independent cells that are poised for clonal selection after androgen-deprivation therapy. Cancer Res; 78(4); 853–64. ©2017 AACR." @default.
• W2775443868 created "2017-12-22" @default.
• W2775443868 creator A5000043199 @default.
• W2775443868 creator A5000970532 @default.
• W2775443868 creator A5006646440 @default.
• W2775443868 creator A5012971026 @default.
• W2775443868 creator A5030919384 @default.
• W2775443868 creator A5031605337 @default.
• W2775443868 creator A5035270667 @default.
• W2775443868 creator A5035733667 @default.
• W2775443868 creator A5040163112 @default.
• W2775443868 creator A5047253579 @default.
• W2775443868 creator A5047504763 @default.
• W2775443868 creator A5047903038 @default.
• W2775443868 creator A5049119185 @default.
• W2775443868 creator A5061902626 @default.
• W2775443868 creator A5065299152 @default.
• W2775443868 creator A5065353699 @default.
• W2775443868 creator A5066355670 @default.
• W2775443868 creator A5067547707 @default.
• W2775443868 date "2018-02-14" @default.
• W2775443868 modified "2023-09-26" @default.
• W2775443868 title "Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle–Related Transcription and Attenuated Androgen Response" @default.
• W2775443868 cites W1919512980 @default.
• W2775443868 cites W1966106148 @default.
• W2775443868 cites W1967327758 @default.
• W2775443868 cites W1978960998 @default.
• W2775443868 cites W1996588663 @default.
• W2775443868 cites W1998147517 @default.
• W2775443868 cites W2000056288 @default.
• W2775443868 cites W2005658600 @default.
• W2775443868 cites W2006653668 @default.
• W2775443868 cites W2007303903 @default.
• W2775443868 cites W2010873488 @default.
• W2775443868 cites W2017757468 @default.
• W2775443868 cites W2019577333 @default.
• W2775443868 cites W2023560061 @default.
• W2775443868 cites W2023771000 @default.
• W2775443868 cites W2038369521 @default.
• W2775443868 cites W2044287047 @default.
• W2775443868 cites W2058013476 @default.
• W2775443868 cites W2060496122 @default.
• W2775443868 cites W2062896874 @default.
• W2775443868 cites W2068767807 @default.
• W2775443868 cites W2074658694 @default.
• W2775443868 cites W2088059732 @default.
• W2775443868 cites W2097065948 @default.
• W2775443868 cites W2113464519 @default.
• W2775443868 cites W2124985265 @default.
• W2775443868 cites W2134526812 @default.
• W2775443868 cites W2156215080 @default.
• W2775443868 cites W2158099560 @default.
• W2775443868 cites W2167277055 @default.
• W2775443868 cites W2174024238 @default.
• W2775443868 cites W2179438025 @default.
• W2775443868 cites W2181283187 @default.
• W2775443868 cites W2290591211 @default.
• W2775443868 cites W2397858436 @default.
• W2775443868 cites W2511755939 @default.
• W2775443868 cites W2519132385 @default.
• W2775443868 cites W2525450724 @default.
• W2775443868 cites W4250766573 @default.
• W2775443868 doi "https://doi.org/10.1158/0008-5472.can-17-1924" @default.
• W2775443868 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5983359" @default.
• W2775443868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29233929" @default.
• W2775443868 hasPublicationYear "2018" @default.
• W2775443868 type Work @default.
• W2775443868 sameAs 2775443868 @default.
• W2775443868 citedByCount "78" @default.
• W2775443868 countsByYear W27754438682018 @default.
• W2775443868 countsByYear W27754438682019 @default.
• W2775443868 countsByYear W27754438682020 @default.
• W2775443868 countsByYear W27754438682021 @default.
• W2775443868 countsByYear W27754438682022 @default.
• W2775443868 countsByYear W27754438682023 @default.
• W2775443868 crossrefType "journal-article" @default.
• W2775443868 hasAuthorship W2775443868A5000043199 @default.
• W2775443868 hasAuthorship W2775443868A5000970532 @default.
• W2775443868 hasAuthorship W2775443868A5006646440 @default.
• W2775443868 hasAuthorship W2775443868A5012971026 @default.
• W2775443868 hasAuthorship W2775443868A5030919384 @default.
• W2775443868 hasAuthorship W2775443868A5031605337 @default.
• W2775443868 hasAuthorship W2775443868A5035270667 @default.
• W2775443868 hasAuthorship W2775443868A5035733667 @default.
• W2775443868 hasAuthorship W2775443868A5040163112 @default.
• W2775443868 hasAuthorship W2775443868A5047253579 @default.
• W2775443868 hasAuthorship W2775443868A5047504763 @default.
• W2775443868 hasAuthorship W2775443868A5047903038 @default.
• W2775443868 hasAuthorship W2775443868A5049119185 @default.
• W2775443868 hasAuthorship W2775443868A5061902626 @default.
• W2775443868 hasAuthorship W2775443868A5065299152 @default.
• W2775443868 hasAuthorship W2775443868A5065353699 @default.
• W2775443868 hasAuthorship W2775443868A5066355670 @default.
• W2775443868 hasAuthorship W2775443868A5067547707 @default.
• W2775443868 hasBestOaLocation W27754438681 @default.
• W2775443868 hasConcept C104317684 @default.
• W2775443868 hasConcept C121608353 @default.
• W2775443868 hasConcept C134018914 @default.

• next