Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775454934> ?p ?o ?g. }
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- W2775454934 abstract "Post-translational protein modification by addition or removal of the small polypeptide ubiquitin is involved in a range of critical cellular processes, like proteasomal protein degradation, DNA repair, gene expression, internalization of membrane proteins, and drug sensitivity. We recently identified genes important for acetaminophen (APAP) toxicity in a comprehensive screen and our findings suggested that a small set of yeast strains carrying deletions of ubiquitin-related genes can be informative for drug toxicity profiling. In yeast, approximately 20 different deubiquitinating enzymes (DUBs) have been identified, of which only one is essential for viability. We investigated whether the toxicity profile of DUB deletion yeast strains would be informative about the toxicological mode of action of APAP. A set of DUB deletion strains was tested for sensitivity and resistance to a diverse series of compounds, including APAP, quinine, ibuprofen, rapamycin, cycloheximide, cadmium, peroxide and amino acids and a cluster analysis was performed. Most DUB deletion strains showed an altered growth pattern when exposed to these compounds by being either more sensitive or more resistant than WT. Toxicity profiling of the DUB strains revealed a remarkable overlap between the amino acid tyrosine and acetaminophen (APAP), but not its stereoisomer AMAP. Furthermore, co-exposure of cells to both APAP and tyrosine showed an enhancement of the cellular growth inhibition, suggesting that APAP and tyrosine have a similar mode of action." @default.
- W2775454934 created "2017-12-22" @default.
- W2775454934 creator A5000869291 @default.
- W2775454934 creator A5020449703 @default.
- W2775454934 creator A5027199677 @default.
- W2775454934 creator A5027247735 @default.
- W2775454934 creator A5032317765 @default.
- W2775454934 creator A5080020012 @default.
- W2775454934 date "2018-03-01" @default.
- W2775454934 modified "2023-10-18" @default.
- W2775454934 title "Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine" @default.
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