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- W2775463245 abstract "OBJECTIVE: Investigate the basis for impaired verb comprehension in amyotrophic lateral sclerosis (ALS) and Parkinson9s disease (PD). BACKGROUND: ALS patients are significantly more impaired with words involving actions than objects, and this impairment pattern correlates with motor association cortex atrophy (Grossman et al, 2008). Parkinson9s Disease (PD) patients also may have significant difficulty naming actions compared to objects (Rodriguez-Ferreiro et al, 2009) and poorer ability naming pictures with high motor content than low motor content (Herrera et al, 2012), although others relate this to their limited executive resources (Grossman et al, 1994). DESIGN/METHODS: ALS patients (n=23), PD patients (n=20) and elderly controls (ELD, n=13) completed a computerized two-alternative forced-choice lexical comprehension task. The task included 60 noun triads (30 concrete and 30 abstract) and 60 verb triads (30 cognitive and 30 motion). Stimuli were matched for imagability, familiarity, age of acquisition, and frequency. RESULTS: ALS patients perform significantly worse than ELD on motion verbs (t=-2.08, p CONCLUSIONS: The selective deficit of ALS patients for motion verbs is consistent with the idea that action features of words are degraded in ALS due to motor association cortex disease. The absence of a verb deficit in PD suggests that representations of action knowledge are preserved in these patients, and is more consistent with prior work suggesting that language deficits in PD are due to executive resource limitations. Supported by: NIH grants: AG032953, NS053488. Disclosure: Dr. York has nothing to disclose. Dr. Camp has nothing to disclose. Dr. Weinberg has nothing to disclose. Dr. Grossman has nothing to disclose." @default.
- W2775463245 created "2017-12-22" @default.
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- W2775463245 date "2013-02-12" @default.
- W2775463245 modified "2023-09-23" @default.
- W2775463245 title "Motion Verb Comprehension in Amyotrophic Lateral Sclerosis and Parkinson's Disease (P07.069)" @default.
- W2775463245 hasPublicationYear "2013" @default.
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