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- W2775550557 abstract "PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions. The PDE4 isoform PDE4B1 also interacts with the DISC1 protein, implicated in neural development and behavioral disorders. The cellular functions of PDE4B1 have been investigated extensively, but its function(s) in the intact organism remained unexplored. To specifically disrupt PDE4B1, we developed mice that express a PDE4B1-D564A transgene in the hippocampus and forebrain. The transgenic mice showed enhanced phosphorylation of CREB and ERK1/2 in hippocampus. Hippocampal neurogenesis was increased in the transgenic mice. Hippocampal electrophysiological studies showed increased baseline synaptic transmission and enhanced LTP in male transgenic mice. Behaviorally, male transgenic mice showed increased activity in prolonged open field testing, but neither male nor female transgenic mice showed detectable anxiety-like behavior or antidepressant effects in the elevated plus-maze, tail-suspension or forced-swim tests. Neither sex showed any significant differences in associative fear conditioning or showed any demonstrable abnormalities in pre-pulse inhibition. These data support the use of an isoform-selective approach to the study of PDE4B1 function in the CNS and suggest a probable role of PDE4B1 in synaptic plasticity and behavior. They also provide additional rationale and a refined approach to the development of small-molecule PDE4B1-selective inhibitors, which have potential functions in disorders of cognition, memory, mood and affect." @default.
- W2775550557 created "2017-12-22" @default.
- W2775550557 creator A5008526202 @default.
- W2775550557 creator A5008732296 @default.
- W2775550557 creator A5009835317 @default.
- W2775550557 creator A5028106593 @default.
- W2775550557 creator A5038128874 @default.
- W2775550557 date "2017-12-01" @default.
- W2775550557 modified "2023-09-27" @default.
- W2775550557 title "Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus" @default.
- W2775550557 cites W1489466981 @default.
- W2775550557 cites W1622692223 @default.
- W2775550557 cites W1671833268 @default.
- W2775550557 cites W1780320592 @default.
- W2775550557 cites W1911444796 @default.
- W2775550557 cites W1920095995 @default.
- W2775550557 cites W1930926196 @default.
- W2775550557 cites W1950744654 @default.
- W2775550557 cites W1964917113 @default.
- W2775550557 cites W1965030220 @default.
- W2775550557 cites W1965032245 @default.
- W2775550557 cites W1967479003 @default.
- W2775550557 cites W1968946845 @default.
- W2775550557 cites W1969819088 @default.
- W2775550557 cites W1970358441 @default.
- W2775550557 cites W1973167605 @default.
- W2775550557 cites W1973966511 @default.
- W2775550557 cites W1974814280 @default.
- W2775550557 cites W1975510659 @default.
- W2775550557 cites W1977490836 @default.
- W2775550557 cites W1978969691 @default.
- W2775550557 cites W1979687697 @default.
- W2775550557 cites W1982108210 @default.
- W2775550557 cites W1984931082 @default.
- W2775550557 cites W1985189974 @default.
- W2775550557 cites W1988004907 @default.
- W2775550557 cites W1989771058 @default.
- W2775550557 cites W1990694352 @default.
- W2775550557 cites W1992203578 @default.
- W2775550557 cites W1993476794 @default.
- W2775550557 cites W1995845195 @default.
- W2775550557 cites W1997277329 @default.
- W2775550557 cites W1997410784 @default.
- W2775550557 cites W1997667243 @default.
- W2775550557 cites W2002927748 @default.
- W2775550557 cites W2003973769 @default.
- W2775550557 cites W2003982930 @default.
- W2775550557 cites W2004353555 @default.
- W2775550557 cites W2005594217 @default.
- W2775550557 cites W2007499520 @default.
- W2775550557 cites W2008020502 @default.
- W2775550557 cites W2010910086 @default.
- W2775550557 cites W2011029903 @default.
- W2775550557 cites W2013666305 @default.
- W2775550557 cites W2015785955 @default.
- W2775550557 cites W2015839373 @default.
- W2775550557 cites W2023414423 @default.
- W2775550557 cites W2023810575 @default.
- W2775550557 cites W2023858737 @default.
- W2775550557 cites W2023920385 @default.
- W2775550557 cites W2025215780 @default.
- W2775550557 cites W2025840069 @default.
- W2775550557 cites W2026082145 @default.
- W2775550557 cites W2026520365 @default.
- W2775550557 cites W2031368107 @default.
- W2775550557 cites W2035000144 @default.
- W2775550557 cites W2038405912 @default.
- W2775550557 cites W2040473218 @default.
- W2775550557 cites W2042295311 @default.
- W2775550557 cites W2045750611 @default.
- W2775550557 cites W2046648030 @default.
- W2775550557 cites W2050513958 @default.
- W2775550557 cites W2051473177 @default.
- W2775550557 cites W2052884971 @default.
- W2775550557 cites W2057496129 @default.
- W2775550557 cites W2057625249 @default.
- W2775550557 cites W2057664366 @default.
- W2775550557 cites W2058019798 @default.
- W2775550557 cites W2064397103 @default.
- W2775550557 cites W2064856888 @default.
- W2775550557 cites W2067780273 @default.
- W2775550557 cites W2068060690 @default.
- W2775550557 cites W2071019848 @default.
- W2775550557 cites W2072126247 @default.
- W2775550557 cites W2072514788 @default.
- W2775550557 cites W2075634772 @default.
- W2775550557 cites W2076312647 @default.
- W2775550557 cites W2076718555 @default.
- W2775550557 cites W2079194017 @default.
- W2775550557 cites W2080084480 @default.
- W2775550557 cites W2080152563 @default.
- W2775550557 cites W2080316797 @default.
- W2775550557 cites W2081382082 @default.
- W2775550557 cites W2082833517 @default.
- W2775550557 cites W2089299823 @default.
- W2775550557 cites W2089627181 @default.
- W2775550557 cites W2095027868 @default.
- W2775550557 cites W2095256251 @default.
- W2775550557 cites W2095832516 @default.
- W2775550557 cites W2096081604 @default.