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- W2775569439 abstract "N-Methyl-d-aspartate (NMDA) receptors have been implicated in learning and memory, and may also play a central role in various conditions leading to neuronal degradation. NMDA receptor antagonists could therefore be of therapeutic benefit for a number of neurological disorders. We have designed hybrid compounds of polyamines and memantine, both of which function as NMDA channel blockers. The triamine derivative with a guanidine moiety showed more potent antagonistic activity than memantine." @default.
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- W2775569439 date "2018-02-01" @default.
- W2775569439 modified "2023-10-18" @default.
- W2775569439 title "Design, synthesis, and evaluation of polyamine-memantine hybrids as NMDA channel blockers" @default.
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- W2775569439 doi "https://doi.org/10.1016/j.bmc.2017.12.021" @default.
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