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• W2775570063 abstract "Production of a biocompatible hyperpolarized bolus for signal amplification by reversible exchange (SABRE) could open the door to simple clinical diagnosis via magnetic resonance imaging. Essential to successful progression to preclinical/clinical applications is the determination of the toxicology profile of the SABRE reaction mixture. Herein, we exemplify the cytotoxicity of the SABRE approach using in vitro cell assays. We conclude that the main cause of the observed toxicity is due to the SABRE catalyst. We therefore illustrate two catalyst removal methods: one involving deactivation and ion-exchange chromatography, and the second using biphasic catalysis. These routes produce a bolus suitable for future in vivo study." @default.
• W2775570063 created "2017-12-22" @default.
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• W2775570063 date "2018-01-18" @default.
• W2775570063 modified "2023-10-17" @default.
• W2775570063 title "Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study" @default.
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• W2775570063 doi "https://doi.org/10.1002/cmdc.201700725" @default.
• W2775570063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5838797" @default.
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