FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775572762> ?p ?o ?g. }

• W2775572762 endingPage "1175" @default.
• W2775572762 startingPage "1157" @default.
• W2775572762 abstract "Nanoparticles (NPs) are easily contaminated by bacterial endotoxin (lipopolysaccharide [LPS]). The presence of LPS can be responsible for many immune/inflammatory effects attributed to NPs. In this study, we examined the effects of LPS adsorption on the NP surface on the formation of a biocorona in biological fluids and on the subsequent inflammation-inducing activity of NPs. Different gold (Au) NPs with sizes ranging from 10 to 80 nm and with different surface functionalization (sodium citrate, lipoic acid, and branched polyethyleneimine (BPEI), or polyethylene glycol (PEG)) were exposed to E. coli LPS under different conditions. The binding capacity of LPS to the surface of AuNPs was dose- and time-dependent. LPS attached to sodium citrate and lipoic acid coatings, but did not adhere to BPEI- or PEG-coated NPs. By computational simulation, the binding of LPS to AuNPs seems to follow the Langmuir absorption isotherm. The presence of LPS on AuNP surface interfered and caused a decrease in the formation of the expected biomolecular corona upon incubation in human plasma. LPS-coated AuNPs, but not the LPS-free NPs, induced significant inflammatory responses in vitro. Notably, while free LPS did also induce an anti-inflammatory response, LPS bound to NPs appeared unable to do so. In conclusion, the unintentional adsorption of LPS onto the NP surface can affect the biocorona formation and the inflammatory properties of NPs. Thus, for an accurate interpretation of NP interactions with cells, it is extremely important to be able to distinguish the intrinsic NP biological effects from those caused by biologically active contaminants such as endotoxin." @default.
• W2775572762 created "2017-12-22" @default.
• W2775572762 creator A5005917189 @default.
• W2775572762 creator A5026895542 @default.
• W2775572762 creator A5028735728 @default.
• W2775572762 creator A5038299644 @default.
• W2775572762 creator A5044297783 @default.
• W2775572762 creator A5050185299 @default.
• W2775572762 creator A5053222195 @default.
• W2775572762 creator A5056354047 @default.
• W2775572762 creator A5056712213 @default.
• W2775572762 creator A5056876135 @default.
• W2775572762 creator A5057246307 @default.
• W2775572762 creator A5057933145 @default.
• W2775572762 creator A5062577468 @default.
• W2775572762 creator A5064842058 @default.
• W2775572762 creator A5065327026 @default.
• W2775572762 creator A5089034752 @default.
• W2775572762 date "2017-11-26" @default.
• W2775572762 modified "2023-10-09" @default.
• W2775572762 title "Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation" @default.
• W2775572762 cites W1966188027 @default.
• W2775572762 cites W1967916767 @default.
• W2775572762 cites W1968012969 @default.
• W2775572762 cites W1974744480 @default.
• W2775572762 cites W1982106711 @default.
• W2775572762 cites W1984411147 @default.
• W2775572762 cites W1997153101 @default.
• W2775572762 cites W2007257062 @default.
• W2775572762 cites W2021194998 @default.
• W2775572762 cites W2027216673 @default.
• W2775572762 cites W2031392804 @default.
• W2775572762 cites W2036296062 @default.
• W2775572762 cites W2038246612 @default.
• W2775572762 cites W2054371878 @default.
• W2775572762 cites W2058269400 @default.
• W2775572762 cites W2058335181 @default.
• W2775572762 cites W2063536881 @default.
• W2775572762 cites W2072176078 @default.
• W2775572762 cites W2089668239 @default.
• W2775572762 cites W2094862469 @default.
• W2775572762 cites W2101312385 @default.
• W2775572762 cites W2108244474 @default.
• W2775572762 cites W2115029038 @default.
• W2775572762 cites W2124041499 @default.
• W2775572762 cites W2125123295 @default.
• W2775572762 cites W2126941192 @default.
• W2775572762 cites W2132278452 @default.
• W2775572762 cites W2133449490 @default.
• W2775572762 cites W2150107812 @default.
• W2775572762 cites W2150704630 @default.
• W2775572762 cites W2153139782 @default.
• W2775572762 cites W2161946327 @default.
• W2775572762 cites W2165275387 @default.
• W2775572762 cites W2252910139 @default.
• W2775572762 cites W2512775114 @default.
• W2775572762 cites W2526220930 @default.
• W2775572762 cites W2550429181 @default.
• W2775572762 cites W2553276534 @default.
• W2775572762 cites W2612164887 @default.
• W2775572762 cites W3023565420 @default.
• W2775572762 doi "https://doi.org/10.1080/17435390.2017.1401142" @default.
• W2775572762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29192556" @default.
• W2775572762 hasPublicationYear "2017" @default.
• W2775572762 type Work @default.
• W2775572762 sameAs 2775572762 @default.
• W2775572762 citedByCount "66" @default.
• W2775572762 countsByYear W27755727622018 @default.
• W2775572762 countsByYear W27755727622019 @default.
• W2775572762 countsByYear W27755727622020 @default.
• W2775572762 countsByYear W27755727622021 @default.
• W2775572762 countsByYear W27755727622022 @default.
• W2775572762 countsByYear W27755727622023 @default.
• W2775572762 crossrefType "journal-article" @default.
• W2775572762 hasAuthorship W2775572762A5005917189 @default.
• W2775572762 hasAuthorship W2775572762A5026895542 @default.
• W2775572762 hasAuthorship W2775572762A5028735728 @default.
• W2775572762 hasAuthorship W2775572762A5038299644 @default.
• W2775572762 hasAuthorship W2775572762A5044297783 @default.
• W2775572762 hasAuthorship W2775572762A5050185299 @default.
• W2775572762 hasAuthorship W2775572762A5053222195 @default.
• W2775572762 hasAuthorship W2775572762A5056354047 @default.
• W2775572762 hasAuthorship W2775572762A5056712213 @default.
• W2775572762 hasAuthorship W2775572762A5056876135 @default.
• W2775572762 hasAuthorship W2775572762A5057246307 @default.
• W2775572762 hasAuthorship W2775572762A5057933145 @default.
• W2775572762 hasAuthorship W2775572762A5062577468 @default.
• W2775572762 hasAuthorship W2775572762A5064842058 @default.
• W2775572762 hasAuthorship W2775572762A5065327026 @default.
• W2775572762 hasAuthorship W2775572762A5089034752 @default.
• W2775572762 hasBestOaLocation W27755727621 @default.
• W2775572762 hasConcept C10138342 @default.
• W2775572762 hasConcept C104819515 @default.
• W2775572762 hasConcept C115537861 @default.
• W2775572762 hasConcept C12554922 @default.
• W2775572762 hasConcept C147789679 @default.
• W2775572762 hasConcept C150394285 @default.
• W2775572762 hasConcept C155672457 @default.

• next