Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775594986> ?p ?o ?g. }
- W2775594986 endingPage "244" @default.
- W2775594986 startingPage "225" @default.
- W2775594986 abstract "Cyclic nucleotide-binding domain (CNBD) channels are a family of ion channels in the voltage-gated K+ channel superfamily that play crucial roles in many physiological processes. CNBD channels are structurally similar but functionally very diverse. This family includes three subfamilies: (1) the cyclic nucleotide-gated (CNG) channels, which are cation-nonselective, voltage-independent, and cyclic nucleotide-gated; (2) the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which are weakly K+ selective, hyperpolarization-activated, and cyclic nucleotide-gated; and (3) the ether-à-go-go-type (KCNH) channels, which are strongly K+ selective, depolarization-activated, and cyclic nucleotide-independent. Recently, several high-resolution structures have been reported for intact CNBD channels, providing a structural framework to better understand their diverse function. In this review, we compare and contrast the recent structures and discuss how they inform our understanding of ion selectivity, voltage-dependent gating, and cyclic nucleotide–dependent gating within this channel family." @default.
- W2775594986 created "2017-12-22" @default.
- W2775594986 creator A5012884846 @default.
- W2775594986 creator A5026207857 @default.
- W2775594986 date "2017-12-12" @default.
- W2775594986 modified "2023-10-12" @default.
- W2775594986 title "Structural insights into the mechanisms of CNBD channel function" @default.
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