Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775677897> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2775677897 abstract "The efficacy of nintedanib, a multitarget receptor tyrosine kinase inhibitor, has been demonstrated in recent randomized controlled trials involving patients with idiopathic pulmonary fibrosis (IPF). However, accelerated disease progression after nintedanib discontinuation has never been reported.We report 2 cases involving patients with a history of IPF who presented with respiratory deterioration at 3 weeks after the discontinuation of nintedanib therapy for IPF. Neither patient fulfilled the definition of acute exacerbation of IPF on unilateral computed tomography.Accelerated disease progression after the discontinuation of nintedanib therapy for IPF.One patient received steroid therapy. The other patient refused to undergo steroid therapy.The first patient showed that the affected lobe exhibited volume loss with traction bronchiectasis after receiving steroid therapy, and succumbed to pneumothorax after 3 months. The other patient was transferred to another hospital because of a decline in his general condition.To our knowledge, this report is the first to document accelerated disease progression after the discontinuation of nintedanib therapy for IPF. Although the accurate mechanism remains unclear, the effects of nintedanib against vascular endothelial growth factor and platelet-derived growth factor receptor may play a role. Our findings suggest that physicians should carefully monitor patients with IPF after nintedanib discontinuation." @default.
- W2775677897 created "2017-12-22" @default.
- W2775677897 creator A5026865435 @default.
- W2775677897 creator A5037160876 @default.
- W2775677897 creator A5039193607 @default.
- W2775677897 creator A5059389959 @default.
- W2775677897 creator A5072440708 @default.
- W2775677897 creator A5075271142 @default.
- W2775677897 creator A5083434613 @default.
- W2775677897 date "2017-12-01" @default.
- W2775677897 modified "2023-10-18" @default.
- W2775677897 title "Suspected accelerated disease progression after discontinuation of nintedanib in patients with idiopathic pulmonary fibrosis" @default.
- W2775677897 cites W178900729 @default.
- W2775677897 cites W1965727465 @default.
- W2775677897 cites W1993559550 @default.
- W2775677897 cites W2001818756 @default.
- W2775677897 cites W2034202045 @default.
- W2775677897 cites W2060808510 @default.
- W2775677897 cites W2062367242 @default.
- W2775677897 cites W2089756110 @default.
- W2775677897 cites W2093556618 @default.
- W2775677897 cites W2096523159 @default.
- W2775677897 cites W2098530232 @default.
- W2775677897 cites W2128208856 @default.
- W2775677897 cites W2138871107 @default.
- W2775677897 cites W2161984127 @default.
- W2775677897 cites W2231248733 @default.
- W2775677897 cites W2440054067 @default.
- W2775677897 doi "https://doi.org/10.1097/md.0000000000009081" @default.
- W2775677897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5728940" @default.
- W2775677897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29245325" @default.
- W2775677897 hasPublicationYear "2017" @default.
- W2775677897 type Work @default.
- W2775677897 sameAs 2775677897 @default.
- W2775677897 citedByCount "3" @default.
- W2775677897 countsByYear W27756778972018 @default.
- W2775677897 countsByYear W27756778972020 @default.
- W2775677897 countsByYear W27756778972022 @default.
- W2775677897 crossrefType "journal-article" @default.
- W2775677897 hasAuthorship W2775677897A5026865435 @default.
- W2775677897 hasAuthorship W2775677897A5037160876 @default.
- W2775677897 hasAuthorship W2775677897A5039193607 @default.
- W2775677897 hasAuthorship W2775677897A5059389959 @default.
- W2775677897 hasAuthorship W2775677897A5072440708 @default.
- W2775677897 hasAuthorship W2775677897A5075271142 @default.
- W2775677897 hasAuthorship W2775677897A5083434613 @default.
- W2775677897 hasBestOaLocation W27756778971 @default.
- W2775677897 hasConcept C126322002 @default.
- W2775677897 hasConcept C141071460 @default.
- W2775677897 hasConcept C2777014857 @default.
- W2775677897 hasConcept C2777714996 @default.
- W2775677897 hasConcept C2778341716 @default.
- W2775677897 hasConcept C2778715236 @default.
- W2775677897 hasConcept C2780171596 @default.
- W2775677897 hasConcept C71924100 @default.
- W2775677897 hasConcept C90924648 @default.
- W2775677897 hasConceptScore W2775677897C126322002 @default.
- W2775677897 hasConceptScore W2775677897C141071460 @default.
- W2775677897 hasConceptScore W2775677897C2777014857 @default.
- W2775677897 hasConceptScore W2775677897C2777714996 @default.
- W2775677897 hasConceptScore W2775677897C2778341716 @default.
- W2775677897 hasConceptScore W2775677897C2778715236 @default.
- W2775677897 hasConceptScore W2775677897C2780171596 @default.
- W2775677897 hasConceptScore W2775677897C71924100 @default.
- W2775677897 hasConceptScore W2775677897C90924648 @default.
- W2775677897 hasLocation W27756778971 @default.
- W2775677897 hasLocation W27756778972 @default.
- W2775677897 hasLocation W27756778973 @default.
- W2775677897 hasLocation W27756778974 @default.
- W2775677897 hasOpenAccess W2775677897 @default.
- W2775677897 hasPrimaryLocation W27756778971 @default.
- W2775677897 hasRelatedWork W2464664289 @default.
- W2775677897 hasRelatedWork W2549144820 @default.
- W2775677897 hasRelatedWork W2775677897 @default.
- W2775677897 hasRelatedWork W2906475862 @default.
- W2775677897 hasRelatedWork W2919506754 @default.
- W2775677897 hasRelatedWork W3185794575 @default.
- W2775677897 hasRelatedWork W3215535255 @default.
- W2775677897 hasRelatedWork W4205609963 @default.
- W2775677897 hasRelatedWork W4214608853 @default.
- W2775677897 hasRelatedWork W4220669495 @default.
- W2775677897 isParatext "false" @default.
- W2775677897 isRetracted "false" @default.
- W2775677897 magId "2775677897" @default.
- W2775677897 workType "article" @default.