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• W2775695514 abstract "Background: Studies showed high prevalence of vitaminD deficiency in kidney transplantation recipients. KDIQO suggests calcidiol should be measured, and deficiency should be corrected. Studies showed that vitaminD treatment attenuates post-transplant bone loss. We evaluated the effect of ultraviolet B(UVB) therapy to serum calcidiol, calcium, phosphorus and iPTH level in kidney transplant recipients and compared with oral 25(OH) vitaminD treatment. Method: Eighteen and twenty two patients were randomized into UVB treatment group(UVB-G) and vitamin D treatment group(VitD-G) respectively. Serum calcidiol, calcium, phosphorus and iPTH level were measured before and after intervention. UVB exposure dose was initiated at dose of 700 mJ/cm2 and the total accumulation dose was6,952 mJ/cm2 in 7thweeks. In VitD-G, oral calcidiol was given at dose of 20,000IUper week. Results: There were no statistically significant differences of gender,age,BMI, Fitzpatrick skin classification, calcium, phosphate, eGFR, serum calcidiol, and iPTH between groups. The mean eGFR, serum cacidiol, and iPTH of UVB-G vs VitD-G were 55.1±2.2 mL/min/1.73m2 vs 54.7±2.8mL/min/1.73m2 (p=0.55), 14.3±4.0ng/mL vs 15.3±5.0ng/mL(p=0.55) and 103.7±7.7pg/mL vs 147.2±6.1pg/mL(p=0.57),respectively. The mean transplantation vintage was 78.8±5.7months vs62.6±4.5months(p=0.51) in UVB-G vs VitD-G. There were no significant differences of immunosuppressive regimen and number of biopsy proven allograft rejection episode between groups. Serum calcidiol was statistically significant increased in both group. In UVB-G, serum calcidiol was increased from baseline to 19.2±4.0ng/mL (P<0.001). In VitD-G, serum calcidiol was statistically significant increased from baseline to 19.9±3.0ng/mL(P<0.001) and was not significant different compared with UVB-G. Also, there were no significant differences of iPTH, calcium, phosphate compared between baseline, at 7th weeks and between groups. The adverse event of UVB included: itching(33.33%) and hyperpigmentation(27.7%). Conclusion: UVB exposure increased serum calcidiol in kidney transplant recipients who has vitamin D deficiency. The UVB exposure dose of 6,952 mJ/cm2 in 7 weeks was as effective as oral 25(OH)vitaminD dose of 20,000IU per week. Based on this result, the optimal exposure of national sun light UVB should be adviced to kidney transplant recipients." @default.
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• W2775695514 date "2014-07-01" @default.
• W2775695514 modified "2023-09-26" @default.
• W2775695514 title "UVB Exposure Increases Serum Calcidiol Level in Vitamin D Deficiency Kidney Transplantation Recipients." @default.
• W2775695514 doi "https://doi.org/10.1097/00007890-201407151-01775" @default.
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