FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775695943> ?p ?o ?g. }

• W2775695943 abstract "Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically associated with all forms of Kaposi's sarcoma worldwide. Little is currently known about the role of microRNAs (miRNAs) in KSHV entry. We recently demonstrated that KSHV induces a plethora of host cell miRNAs during the early stages of infection. In this study, we show the ability of host cell novel miR-36 to specifically inhibit KSHV-induced expression of interferon induced transmembrane protein 1 (IFITM1) to limit virus infection of cells. Transfecting cells with miR-36 mimic specifically lowered IFITM1 expression and thereby significantly dampening KSHV infection. In contrast, inhibition of miR-36 using miR-36 inhibitor had the direct opposite effect on KSHV infection of cells, allowing enhanced viral infection of cells. The effect of miR-36 on KSHV infection of cells was at a post-binding stage of virus entry. The highlight of this work was in deciphering a common theme in the ability of miR-36 to regulate infection of closely related DNA viruses: KSHV, Epstein-Barr virus (EBV), and herpes simplexvirus-2 (HSV-2). Taken together, we report for the first time the ability of host cell miRNA to regulate internalization of KSHV, EBV, and HSV-2 in hematopoietic and endothelial cells." @default.
• W2775695943 created "2017-12-22" @default.
• W2775695943 creator A5055119130 @default.
• W2775695943 creator A5071016461 @default.
• W2775695943 date "2017-12-01" @default.
• W2775695943 modified "2023-10-14" @default.
• W2775695943 title "miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)" @default.
• W2775695943 cites W148121814 @default.
• W2775695943 cites W1753997046 @default.
• W2775695943 cites W1877149370 @default.
• W2775695943 cites W1965306643 @default.
• W2775695943 cites W1970199385 @default.
• W2775695943 cites W1982194661 @default.
• W2775695943 cites W1987903396 @default.
• W2775695943 cites W2003988251 @default.
• W2775695943 cites W2010285985 @default.
• W2775695943 cites W2012935881 @default.
• W2775695943 cites W2015779295 @default.
• W2775695943 cites W2017426710 @default.
• W2775695943 cites W2021349374 @default.
• W2775695943 cites W2032438721 @default.
• W2775695943 cites W2035509260 @default.
• W2775695943 cites W2036594413 @default.
• W2775695943 cites W2038521079 @default.
• W2775695943 cites W2042433863 @default.
• W2775695943 cites W2058906301 @default.
• W2775695943 cites W2063104329 @default.
• W2775695943 cites W2064408054 @default.
• W2775695943 cites W2064640692 @default.
• W2775695943 cites W2067736077 @default.
• W2775695943 cites W2068207796 @default.
• W2775695943 cites W2068214145 @default.
• W2775695943 cites W2070690383 @default.
• W2775695943 cites W2072414245 @default.
• W2775695943 cites W2088243322 @default.
• W2775695943 cites W2093874299 @default.
• W2775695943 cites W2097928174 @default.
• W2775695943 cites W2098334437 @default.
• W2775695943 cites W2100061203 @default.
• W2775695943 cites W2103858327 @default.
• W2775695943 cites W2105870066 @default.
• W2775695943 cites W2105934624 @default.
• W2775695943 cites W2107675979 @default.
• W2775695943 cites W2118566027 @default.
• W2775695943 cites W2120169383 @default.
• W2775695943 cites W2124670069 @default.
• W2775695943 cites W2135407078 @default.
• W2775695943 cites W2137519748 @default.
• W2775695943 cites W2140209056 @default.
• W2775695943 cites W2141199943 @default.
• W2775695943 cites W2143314736 @default.
• W2775695943 cites W2157051716 @default.
• W2775695943 cites W2160063406 @default.
• W2775695943 cites W2161187364 @default.
• W2775695943 cites W2161818718 @default.
• W2775695943 cites W2164084422 @default.
• W2775695943 cites W2166616288 @default.
• W2775695943 cites W2167006210 @default.
• W2775695943 cites W2170640437 @default.
• W2775695943 cites W2183857290 @default.
• W2775695943 cites W2197749995 @default.
• W2775695943 cites W2410723119 @default.
• W2775695943 cites W2412429045 @default.
• W2775695943 cites W2487363367 @default.
• W2775695943 cites W2563947691 @default.
• W2775695943 cites W2571060577 @default.
• W2775695943 cites W2578606862 @default.
• W2775695943 cites W2592143061 @default.
• W2775695943 cites W2592780432 @default.
• W2775695943 cites W2597435427 @default.
• W2775695943 cites W2734733596 @default.
• W2775695943 cites W2735635820 @default.
• W2775695943 cites W2748329964 @default.
• W2775695943 cites W2985009201 @default.
• W2775695943 cites W65709665 @default.
• W2775695943 doi "https://doi.org/10.1038/s41598-017-18225-w" @default.
• W2775695943 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5740118" @default.
• W2775695943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29269892" @default.
• W2775695943 hasPublicationYear "2017" @default.
• W2775695943 type Work @default.
• W2775695943 sameAs 2775695943 @default.
• W2775695943 citedByCount "20" @default.
• W2775695943 countsByYear W27756959432018 @default.
• W2775695943 countsByYear W27756959432019 @default.
• W2775695943 countsByYear W27756959432020 @default.
• W2775695943 countsByYear W27756959432021 @default.
• W2775695943 countsByYear W27756959432022 @default.
• W2775695943 countsByYear W27756959432023 @default.
• W2775695943 crossrefType "journal-article" @default.
• W2775695943 hasAuthorship W2775695943A5055119130 @default.
• W2775695943 hasAuthorship W2775695943A5071016461 @default.
• W2775695943 hasBestOaLocation W27756959431 @default.
• W2775695943 hasConcept C104317684 @default.
• W2775695943 hasConcept C145059251 @default.
• W2775695943 hasConcept C159047783 @default.
• W2775695943 hasConcept C170493617 @default.
• W2775695943 hasConcept C24530287 @default.
• W2775695943 hasConcept C2522874641 @default.
• W2775695943 hasConcept C2776178377 @default.
• W2775695943 hasConcept C2776409557 @default.

• next