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• W2775762809 abstract "We designed a multimeric nuclease‐resistant 63‐bp trimeric small‐interfering RNA (tsi RNA ) comprising in one duplex the sequence of si RNA s targeting mRNA s of MDR 1 , LMP 2 , and LMP 7 genes. We show that such tsi RNA is able to suppress the expression of all the target genes independently and with high efficiency, acting via a Dicer‐dependent mechanism. tsi RNA is diced into 42‐ and 21‐bp duplexes inside the cell. tsi RNA ‐induced gene silencing is characterized by kinetics similar to that of canonical si RNA , while the silencing efficiency is significantly higher than that of canonical si RNA with the same sequence." @default.
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• W2775762809 date "2017-12-29" @default.
• W2775762809 modified "2023-09-26" @default.
• W2775762809 title "Nuclease‐resistant 63‐bp trimeric si<scp>RNA</scp>s simultaneously silence three different genes in tumor cells" @default.
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• W2775762809 doi "https://doi.org/10.1002/1873-3468.12927" @default.
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