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- W2775794168 abstract "Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes. Moreover, patients with hypertension often exhibit insulin resistance and are at greater risk of diabetes developing than are normotensive individuals. The major cause of morbidity and mortality in diabetes is cardiovascular disease, which is exacerbated by hypertension. Accordingly, diabetes and hypertension are closely interlinked because of similar risk factors, such as endothelial dysfunction, vascular inflammation, arterial remodelling, atherosclerosis, dyslipidemia, and obesity. There is also substantial overlap in the cardiovascular complications of diabetes and hypertension related primarily to microvascular and macrovascular disease. Common mechanisms, such as upregulation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, and activation of the immune system likely contribute to the close relationship between diabetes and hypertension. In this article we discuss diabetes and hypertension as comorbidities and discuss the pathophysiological features of vascular complications associated with these conditions. We also highlight some vascular mechanisms that predispose to both conditions, focusing on advanced glycation end products, oxidative stress, inflammation, the immune system, and microRNAs. Finally, we provide some insights into current therapies targeting diabetes and cardiovascular complications and introduce some new agents that may have vasoprotective therapeutic potential in diabetes." @default.
- W2775794168 created "2017-12-22" @default.
- W2775794168 creator A5020577597 @default.
- W2775794168 creator A5040329167 @default.
- W2775794168 creator A5077595764 @default.
- W2775794168 date "2018-05-01" @default.
- W2775794168 modified "2023-10-14" @default.
- W2775794168 title "Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms" @default.
- W2775794168 cites W1507217056 @default.
- W2775794168 cites W1558367558 @default.
- W2775794168 cites W1844037985 @default.
- W2775794168 cites W1849517704 @default.
- W2775794168 cites W1896964083 @default.
- W2775794168 cites W189857981 @default.
- W2775794168 cites W1904336231 @default.
- W2775794168 cites W1964891036 @default.
- W2775794168 cites W1968144622 @default.
- W2775794168 cites W1969965782 @default.
- W2775794168 cites W1976928728 @default.
- W2775794168 cites W1978804351 @default.
- W2775794168 cites W1981905227 @default.
- W2775794168 cites W1984007392 @default.
- W2775794168 cites W1995897557 @default.
- W2775794168 cites W2001167919 @default.
- W2775794168 cites W2006804028 @default.
- W2775794168 cites W2012214559 @default.
- W2775794168 cites W2016963008 @default.
- W2775794168 cites W2023456363 @default.
- W2775794168 cites W2032556453 @default.
- W2775794168 cites W2032803378 @default.
- W2775794168 cites W2035902115 @default.
- W2775794168 cites W2036732719 @default.
- W2775794168 cites W2042130085 @default.
- W2775794168 cites W2045623236 @default.
- W2775794168 cites W2047050907 @default.
- W2775794168 cites W2049036672 @default.
- W2775794168 cites W2049445482 @default.
- W2775794168 cites W2053518007 @default.
- W2775794168 cites W2065995883 @default.
- W2775794168 cites W2067503419 @default.
- W2775794168 cites W2082622955 @default.
- W2775794168 cites W2083625489 @default.
- W2775794168 cites W2084962003 @default.
- W2775794168 cites W2098414680 @default.
- W2775794168 cites W2100023008 @default.
- W2775794168 cites W2104842795 @default.
- W2775794168 cites W2109194972 @default.
- W2775794168 cites W2109689720 @default.
- W2775794168 cites W2109728760 @default.
- W2775794168 cites W2111202666 @default.
- W2775794168 cites W2116420100 @default.
- W2775794168 cites W2123895126 @default.
- W2775794168 cites W2126149568 @default.
- W2775794168 cites W2134625795 @default.
- W2775794168 cites W2137012624 @default.
- W2775794168 cites W2144354169 @default.
- W2775794168 cites W2146264128 @default.
- W2775794168 cites W2153249592 @default.
- W2775794168 cites W2158298073 @default.
- W2775794168 cites W2159602704 @default.
- W2775794168 cites W2159969745 @default.
- W2775794168 cites W2161432971 @default.
- W2775794168 cites W2163109807 @default.
- W2775794168 cites W2165256339 @default.
- W2775794168 cites W2168261002 @default.
- W2775794168 cites W2172124430 @default.
- W2775794168 cites W2186801162 @default.
- W2775794168 cites W2188846692 @default.
- W2775794168 cites W2195393144 @default.
- W2775794168 cites W2196045865 @default.
- W2775794168 cites W2206214621 @default.
- W2775794168 cites W2209633084 @default.
- W2775794168 cites W2219791300 @default.
- W2775794168 cites W2289993018 @default.
- W2775794168 cites W2304572562 @default.
- W2775794168 cites W2319850088 @default.
- W2775794168 cites W2331274940 @default.
- W2775794168 cites W2332434525 @default.
- W2775794168 cites W2336310405 @default.
- W2775794168 cites W2412800896 @default.
- W2775794168 cites W2425644022 @default.
- W2775794168 cites W2471605942 @default.
- W2775794168 cites W2473393131 @default.
- W2775794168 cites W2475233216 @default.
- W2775794168 cites W2501890046 @default.
- W2775794168 cites W2504981678 @default.
- W2775794168 cites W2513040800 @default.
- W2775794168 cites W2521968048 @default.
- W2775794168 cites W2559004714 @default.
- W2775794168 cites W2560781586 @default.
- W2775794168 cites W2574128142 @default.
- W2775794168 cites W2575825106 @default.
- W2775794168 cites W2581527741 @default.
- W2775794168 cites W2584476126 @default.
- W2775794168 cites W2587108949 @default.
- W2775794168 cites W2587680743 @default.
- W2775794168 cites W2591646518 @default.
- W2775794168 cites W2592071158 @default.