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- W2775794980 abstract "Vitamin K is mainly known as an agent involved in blood coagulation, maintaining the activity of coagulation factors in the liver. In addition, epidemiological studies suggested that a lack of vitamin K is associated with several diseases, including osteoporosis and vascular calcification. There are two main kinds of vitamin K: Phylloquinone (or PK) and Menaquinones (MKn), both act as co-enzyme of y-glutamyl carboxylase (GGCX) transforming under-carboxylated in carboxylated vitamin K dependent proteins, such as Bone Gla Protein (or Osteocalcin) and Matrix Gla Protein. Recently, Vitamin K was also identified as a ligand of the nuclear steroid and xenobiotic receptor (SXR) (in murine species Pregnane X Receptor: PXR), expressed in osteoblasts. The purpose of this literature review is to evaluate the protective role of Vitamin K in bone and vascular health." @default.
- W2775794980 created "2017-12-22" @default.
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- W2775794980 date "2017-01-01" @default.
- W2775794980 modified "2023-09-24" @default.
- W2775794980 title "Vitamin K and bone" @default.
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- W2775794980 doi "https://doi.org/10.11138/ccmbm/2017.14.1.200" @default.
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