FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775795939> ?p ?o ?g. }

• W2775795939 endingPage "48" @default.
• W2775795939 startingPage "41" @default.
• W2775795939 abstract "There are over 400 hypoxic zones in the ocean worldwide. Both laboratory and field studies have shown that hypoxia causes endocrine disruption and reproductive impairments in vertebrates. More importantly, our recent study discovered that parental (F0) hypoxia exposure resulted in the transgenerational impairment of sperm quality in the F2 generation through the epigenetic regulation of germ cells. In the present study, we aim to test the hypothesis that the brain, as the major regulator of the brain-pituitary-gonad (BPG) axis, is also involved in the observed transgenerational effect. Using comparative transcriptomic analysis on brain tissues of marine medaka Oryzias melastigma, 45 common differentially expressed genes caused by parental hypoxia exposure were found in the hypoxic group of the F0 and F2 generations, and the transgenerational groups of the F2 generation. The bioinformatic analysis on this deregulated gene cluster further highlighted the possible involvement of the brain in the transgenerational effect of hypoxia on testicular structure, including abnormal morphologies of the epididymis and the seminal vesicle, and degeneration of the seminiferous tubule. This finding is concordant to the result of hematoxylin and eosin staining, which showed the reduction of testicular lobular diameter in the F0 and F2 generations. Our study demonstrated for the first time the involvement of the brain in the transgenerational effect of hypoxia." @default.
• W2775795939 created "2017-12-22" @default.
• W2775795939 creator A5015031711 @default.
• W2775795939 creator A5028630779 @default.
• W2775795939 creator A5032520360 @default.
• W2775795939 creator A5033030673 @default.
• W2775795939 creator A5073321237 @default.
• W2775795939 creator A5073868409 @default.
• W2775795939 creator A5080235217 @default.
• W2775795939 creator A5080333215 @default.
• W2775795939 creator A5083578495 @default.
• W2775795939 date "2018-02-01" @default.
• W2775795939 modified "2023-09-30" @default.
• W2775795939 title "Transcriptomic analysis reveals transgenerational effect of hypoxia on the neural control of testicular functions" @default.
• W2775795939 cites W12286797 @default.
• W2775795939 cites W1964965329 @default.
• W2775795939 cites W1972673307 @default.
• W2775795939 cites W1972755971 @default.
• W2775795939 cites W1979201237 @default.
• W2775795939 cites W1980812873 @default.
• W2775795939 cites W1993798011 @default.
• W2775795939 cites W2007644527 @default.
• W2775795939 cites W2014388728 @default.
• W2775795939 cites W2014740559 @default.
• W2775795939 cites W2018784772 @default.
• W2775795939 cites W2019899136 @default.
• W2775795939 cites W2030676023 @default.
• W2775795939 cites W2035474677 @default.
• W2775795939 cites W2041551489 @default.
• W2775795939 cites W2052097318 @default.
• W2775795939 cites W2054011395 @default.
• W2775795939 cites W2057244558 @default.
• W2775795939 cites W2058670228 @default.
• W2775795939 cites W2085884111 @default.
• W2775795939 cites W2094994063 @default.
• W2775795939 cites W2105420483 @default.
• W2775795939 cites W2114104545 @default.
• W2775795939 cites W2117173977 @default.
• W2775795939 cites W2119807671 @default.
• W2775795939 cites W2120527285 @default.
• W2775795939 cites W2130231032 @default.
• W2775795939 cites W2132969076 @default.
• W2775795939 cites W2133465414 @default.
• W2775795939 cites W2141973741 @default.
• W2775795939 cites W2158217645 @default.
• W2775795939 cites W2168015911 @default.
• W2775795939 cites W2170979668 @default.
• W2775795939 cites W2323326409 @default.
• W2775795939 cites W2470948111 @default.
• W2775795939 cites W2526745866 @default.
• W2775795939 cites W2531806565 @default.
• W2775795939 cites W2586989650 @default.
• W2775795939 doi "https://doi.org/10.1016/j.aquatox.2017.12.005" @default.
• W2775795939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29276994" @default.
• W2775795939 hasPublicationYear "2018" @default.
• W2775795939 type Work @default.
• W2775795939 sameAs 2775795939 @default.
• W2775795939 citedByCount "11" @default.
• W2775795939 countsByYear W27757959392019 @default.
• W2775795939 countsByYear W27757959392020 @default.
• W2775795939 countsByYear W27757959392021 @default.
• W2775795939 countsByYear W27757959392022 @default.
• W2775795939 crossrefType "journal-article" @default.
• W2775795939 hasAuthorship W2775795939A5015031711 @default.
• W2775795939 hasAuthorship W2775795939A5028630779 @default.
• W2775795939 hasAuthorship W2775795939A5032520360 @default.
• W2775795939 hasAuthorship W2775795939A5033030673 @default.
• W2775795939 hasAuthorship W2775795939A5073321237 @default.
• W2775795939 hasAuthorship W2775795939A5073868409 @default.
• W2775795939 hasAuthorship W2775795939A5080235217 @default.
• W2775795939 hasAuthorship W2775795939A5080333215 @default.
• W2775795939 hasAuthorship W2775795939A5083578495 @default.
• W2775795939 hasConcept C104317684 @default.
• W2775795939 hasConcept C126322002 @default.
• W2775795939 hasConcept C134018914 @default.
• W2775795939 hasConcept C150194340 @default.
• W2775795939 hasConcept C162317418 @default.
• W2775795939 hasConcept C16685009 @default.
• W2775795939 hasConcept C178790620 @default.
• W2775795939 hasConcept C185592680 @default.
• W2775795939 hasConcept C2777289358 @default.
• W2775795939 hasConcept C2781087480 @default.
• W2775795939 hasConcept C2781471917 @default.
• W2775795939 hasConcept C42407357 @default.
• W2775795939 hasConcept C540031477 @default.
• W2775795939 hasConcept C54355233 @default.
• W2775795939 hasConcept C71924100 @default.
• W2775795939 hasConcept C7836513 @default.
• W2775795939 hasConcept C86803240 @default.
• W2775795939 hasConceptScore W2775795939C104317684 @default.
• W2775795939 hasConceptScore W2775795939C126322002 @default.
• W2775795939 hasConceptScore W2775795939C134018914 @default.
• W2775795939 hasConceptScore W2775795939C150194340 @default.
• W2775795939 hasConceptScore W2775795939C162317418 @default.
• W2775795939 hasConceptScore W2775795939C16685009 @default.
• W2775795939 hasConceptScore W2775795939C178790620 @default.
• W2775795939 hasConceptScore W2775795939C185592680 @default.
• W2775795939 hasConceptScore W2775795939C2777289358 @default.

• next