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- W2775802376 abstract "Human immunodeficiency virus (HIV) infection is associated with B-cell malignancies in patients though HIV-1 is not able to infect B-cells. The rate of B-cell lymphomas in HIV-infected individuals remains high even under the combined antiretroviral therapy (cART) that reconstitutes the immune function. Thus, the contribution of HIV-1 to B-cell oncogenesis remains enigmatic. HIV-1 induces oxidative stress and DNA damage in infected cells via multiple mechanisms, including viral Tat protein. We have detected elevated levels of reactive oxygen species (ROS) and DNA damage in B-cells of HIV-infected individuals. As Tat is present in blood of infected individuals and is able to transduce cells, we hypothesized that it could induce oxidative DNA damage in B-cells promoting genetic instability and malignant transformation. Indeed, incubation of B-cells isolated from healthy donors with purified Tat protein led to oxidative stress, a decrease in the glutathione (GSH) levels, DNA damage and appearance of chromosomal aberrations. The effects of Tat relied on its transcriptional activity and were mediated by NF-κB activation. Tat stimulated oxidative stress in B-cells mostly via mitochondrial ROS production which depended on the reverse electron flow in Complex I of respiratory chain. We propose that Tat-induced oxidative stress, DNA damage and chromosomal aberrations are novel oncogenic factors favoring B-cell lymphomas in HIV-1 infected individuals." @default.
- W2775802376 created "2017-12-22" @default.
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- W2775802376 date "2018-05-01" @default.
- W2775802376 modified "2023-10-17" @default.
- W2775802376 title "HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production" @default.
- W2775802376 cites W131142930 @default.
- W2775802376 cites W1506411711 @default.
- W2775802376 cites W1547027526 @default.
- W2775802376 cites W1570188208 @default.
- W2775802376 cites W1602425415 @default.
- W2775802376 cites W1602448887 @default.
- W2775802376 cites W1896714280 @default.
- W2775802376 cites W1926895509 @default.
- W2775802376 cites W1945197454 @default.
- W2775802376 cites W1962437344 @default.
- W2775802376 cites W1963712961 @default.
- W2775802376 cites W1965151932 @default.
- W2775802376 cites W1973462494 @default.
- W2775802376 cites W1975707478 @default.
- W2775802376 cites W1976733038 @default.
- W2775802376 cites W1980538557 @default.
- W2775802376 cites W1980780168 @default.
- W2775802376 cites W1987880652 @default.
- W2775802376 cites W1989369955 @default.
- W2775802376 cites W1991580205 @default.
- W2775802376 cites W1993872957 @default.
- W2775802376 cites W1994025158 @default.
- W2775802376 cites W1994758284 @default.
- W2775802376 cites W1996258759 @default.
- W2775802376 cites W1997579184 @default.
- W2775802376 cites W1997765594 @default.
- W2775802376 cites W2000137301 @default.
- W2775802376 cites W2002053621 @default.
- W2775802376 cites W2002805664 @default.
- W2775802376 cites W2006212386 @default.
- W2775802376 cites W2007448480 @default.
- W2775802376 cites W2010311619 @default.
- W2775802376 cites W2011979546 @default.
- W2775802376 cites W2013607754 @default.
- W2775802376 cites W2019369653 @default.
- W2775802376 cites W2025791120 @default.
- W2775802376 cites W2030477444 @default.
- W2775802376 cites W2035396914 @default.
- W2775802376 cites W2036929827 @default.
- W2775802376 cites W2037864697 @default.
- W2775802376 cites W2041698668 @default.
- W2775802376 cites W2043037824 @default.
- W2775802376 cites W2043541543 @default.
- W2775802376 cites W2044500327 @default.
- W2775802376 cites W2044532912 @default.
- W2775802376 cites W2048553024 @default.
- W2775802376 cites W2049384855 @default.
- W2775802376 cites W2049519942 @default.
- W2775802376 cites W2049636133 @default.
- W2775802376 cites W2055199664 @default.
- W2775802376 cites W2056612619 @default.
- W2775802376 cites W2060991251 @default.
- W2775802376 cites W2064581549 @default.
- W2775802376 cites W2067592236 @default.
- W2775802376 cites W2078057032 @default.
- W2775802376 cites W2078252226 @default.
- W2775802376 cites W2080997681 @default.
- W2775802376 cites W2084299658 @default.
- W2775802376 cites W2086667809 @default.
- W2775802376 cites W2086911518 @default.
- W2775802376 cites W2087790613 @default.
- W2775802376 cites W2095563284 @default.
- W2775802376 cites W2096603314 @default.
- W2775802376 cites W2100286172 @default.
- W2775802376 cites W2107091218 @default.
- W2775802376 cites W2107447582 @default.
- W2775802376 cites W2108156511 @default.
- W2775802376 cites W2109183702 @default.
- W2775802376 cites W2109439589 @default.
- W2775802376 cites W2112562554 @default.
- W2775802376 cites W2122341467 @default.
- W2775802376 cites W2123250752 @default.
- W2775802376 cites W2125558097 @default.
- W2775802376 cites W2129600663 @default.
- W2775802376 cites W2131646714 @default.
- W2775802376 cites W2134887638 @default.
- W2775802376 cites W2135028625 @default.
- W2775802376 cites W2136949148 @default.
- W2775802376 cites W2139204503 @default.