FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775803378> ?p ?o ?g. }

• W2775803378 endingPage "1221" @default.
• W2775803378 startingPage "1209" @default.
• W2775803378 abstract "DFNA9 is a rare progressive autosomal dominantly inherited vestibulo-cochlear disorder, resulting in a homogeneous group of patients with hearing impairment and bilateral vestibular function loss. These patients suffer from a deteriorated sense of spatial orientation, leading to balance problems in darkness, especially on irregular surfaces. Both behavioral and functional imaging studies suggest that the remaining sensory cues could compensate for the loss of vestibular information. A thorough model-based quantification of this reweighting in individual patients is, however, missing. Here we psychometrically examined the individual patient’s sensory reweighting of these cues after complete vestibular loss. We asked a group of DFNA9 patients and healthy control subjects to judge the orientation (clockwise or counterclockwise relative to gravity) of a rod presented within an oriented square frame (rod-in-frame task) in three different head-on-body tilt conditions. Our results show a cyclical frame-induced bias in perceived gravity direction across a 90° range of frame orientations. The magnitude of this bias was significantly increased in the patients compared with the healthy control subjects. Response variability, which increased with head-on-body tilt, was also larger for the patients. Reverse engineering of the underlying signal properties, using Bayesian inference principles, suggests a reweighting of sensory signals, with an increase in visual weight of 20–40% in the patients. Our approach of combining psychophysics and Bayesian reverse engineering is the first to quantify the weights associated with the different sensory modalities at an individual patient level, which could make it possible to develop personal rehabilitation programs based on the patient’s sensory weight distribution. NEW & NOTEWORTHY It has been suggested that patients with vestibular deficits can compensate for this loss by increasing reliance on other sensory cues, although an actual quantification of this reweighting is lacking. We combine experimental psychophysics with a reverse engineering approach based on Bayesian inference principles to quantify sensory reweighting in individual vestibular patients. We discuss the suitability of this approach for developing personal rehabilitation programs based on the patient’s sensory weight distribution." @default.
• W2775803378 created "2017-12-22" @default.
• W2775803378 creator A5001516018 @default.
• W2775803378 creator A5009220583 @default.
• W2775803378 creator A5035681062 @default.
• W2775803378 creator A5054563537 @default.
• W2775803378 creator A5089992471 @default.
• W2775803378 date "2018-03-01" @default.
• W2775803378 modified "2023-10-10" @default.
• W2775803378 title "Bayesian quantification of sensory reweighting in a familial bilateral vestibular disorder (DFNA9)" @default.
• W2775803378 cites W1471548710 @default.
• W2775803378 cites W1622529596 @default.
• W2775803378 cites W1965103398 @default.
• W2775803378 cites W1966477239 @default.
• W2775803378 cites W1966646149 @default.
• W2775803378 cites W1981630563 @default.
• W2775803378 cites W1985826016 @default.
• W2775803378 cites W1989554443 @default.
• W2775803378 cites W1992943860 @default.
• W2775803378 cites W1995700755 @default.
• W2775803378 cites W2003468984 @default.
• W2775803378 cites W2004653741 @default.
• W2775803378 cites W2005324857 @default.
• W2775803378 cites W2008098737 @default.
• W2775803378 cites W2008366397 @default.
• W2775803378 cites W2014273393 @default.
• W2775803378 cites W2014584736 @default.
• W2775803378 cites W2014767327 @default.
• W2775803378 cites W2016711550 @default.
• W2775803378 cites W2018482554 @default.
• W2775803378 cites W2021063869 @default.
• W2775803378 cites W2027648026 @default.
• W2775803378 cites W2031525215 @default.
• W2775803378 cites W2033827298 @default.
• W2775803378 cites W2035912487 @default.
• W2775803378 cites W2036785644 @default.
• W2775803378 cites W2044253299 @default.
• W2775803378 cites W2048873987 @default.
• W2775803378 cites W2049584668 @default.
• W2775803378 cites W2067128351 @default.
• W2775803378 cites W2067640614 @default.
• W2775803378 cites W2070164636 @default.
• W2775803378 cites W2074099492 @default.
• W2775803378 cites W2074992926 @default.
• W2775803378 cites W2078120805 @default.
• W2775803378 cites W2079285723 @default.
• W2775803378 cites W2082893725 @default.
• W2775803378 cites W2084090359 @default.
• W2775803378 cites W2086238315 @default.
• W2775803378 cites W2091780520 @default.
• W2775803378 cites W2094405631 @default.
• W2775803378 cites W2095973660 @default.
• W2775803378 cites W2099204763 @default.
• W2775803378 cites W2102131965 @default.
• W2775803378 cites W2103125163 @default.
• W2775803378 cites W2104700416 @default.
• W2775803378 cites W2107118034 @default.
• W2775803378 cites W2109397194 @default.
• W2775803378 cites W2109550192 @default.
• W2775803378 cites W2112772615 @default.
• W2775803378 cites W2117215414 @default.
• W2775803378 cites W2117574800 @default.
• W2775803378 cites W2118827914 @default.
• W2775803378 cites W2123882491 @default.
• W2775803378 cites W2124637035 @default.
• W2775803378 cites W2130593351 @default.
• W2775803378 cites W2131215403 @default.
• W2775803378 cites W2136621021 @default.
• W2775803378 cites W2140066903 @default.
• W2775803378 cites W2142013636 @default.
• W2775803378 cites W2148485008 @default.
• W2775803378 cites W2149148092 @default.
• W2775803378 cites W2150742328 @default.
• W2775803378 cites W2153173219 @default.
• W2775803378 cites W2157217908 @default.
• W2775803378 cites W2162182804 @default.
• W2775803378 cites W2168323170 @default.
• W2775803378 cites W2169139301 @default.
• W2775803378 cites W2169352760 @default.
• W2775803378 cites W2171526597 @default.
• W2775803378 cites W2173707989 @default.
• W2775803378 cites W2258613981 @default.
• W2775803378 cites W2301481832 @default.
• W2775803378 cites W2313575944 @default.
• W2775803378 cites W2334999251 @default.
• W2775803378 cites W2337135264 @default.
• W2775803378 cites W2535286602 @default.
• W2775803378 cites W2538473790 @default.
• W2775803378 cites W2563981756 @default.
• W2775803378 cites W4236982648 @default.
• W2775803378 cites W4239816177 @default.
• W2775803378 cites W4248242229 @default.
• W2775803378 cites W4249953541 @default.
• W2775803378 cites W4255519348 @default.
• W2775803378 doi "https://doi.org/10.1152/jn.00082.2017" @default.
• W2775803378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5899303" @default.
• W2775803378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29357473" @default.
• W2775803378 hasPublicationYear "2018" @default.

• next