FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775824694> ?p ?o ?g. }

• W2775824694 abstract "Hypoxia-inducible factor 1α (HIF1α) induces the expression of several hundred genes in hypoxia aiming at restoration of oxygen homeostasis. HIF prolyl-4-hydroxylases (HIF-P4Hs) regulate the stability of HIF1α in an oxygen-dependent manner. Hypoxia is a common feature in inflammation and cancer and the HIF pathway is closely linked with the inflammatory NF-κB and tumor suppressor p53 pathways. Here we show that genetic inactivation or chemical inhibition of HIF-P4H-1 leads to downregulation of proinflammatory genes, while proapoptotic genes are upregulated. HIF-P4H-1 inactivation reduces the inflammatory response under LPS stimulus in vitro and in an acute skin inflammation model in vivo. Furthermore, HIF-P4H-1 inactivation increases p53 activity and stability and hydroxylation of proline 142 in p53 has an important role in this regulation. Altogether, our data suggest that HIF-P4H-1 inhibition may be a promising therapeutic candidate for inflammatory diseases and cancer, enhancing the reciprocal negative regulation of the NF-κB and p53 pathways." @default.
• W2775824694 created "2017-12-22" @default.
• W2775824694 creator A5002072250 @default.
• W2775824694 creator A5007573138 @default.
• W2775824694 creator A5019926598 @default.
• W2775824694 creator A5036252076 @default.
• W2775824694 creator A5036847022 @default.
• W2775824694 creator A5079944076 @default.
• W2775824694 creator A5086470309 @default.
• W2775824694 date "2017-12-08" @default.
• W2775824694 modified "2023-10-13" @default.
• W2775824694 title "Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways" @default.
• W2775824694 cites W1619977460 @default.
• W2775824694 cites W1625769635 @default.
• W2775824694 cites W1832538561 @default.
• W2775824694 cites W1900398835 @default.
• W2775824694 cites W1967364108 @default.
• W2775824694 cites W1970971661 @default.
• W2775824694 cites W1975160071 @default.
• W2775824694 cites W1981534498 @default.
• W2775824694 cites W1988377666 @default.
• W2775824694 cites W1993170641 @default.
• W2775824694 cites W1993324234 @default.
• W2775824694 cites W1994211285 @default.
• W2775824694 cites W1999177172 @default.
• W2775824694 cites W2005539293 @default.
• W2775824694 cites W2005729255 @default.
• W2775824694 cites W2005868568 @default.
• W2775824694 cites W2008541833 @default.
• W2775824694 cites W2012292879 @default.
• W2775824694 cites W2021056570 @default.
• W2775824694 cites W2021932335 @default.
• W2775824694 cites W2030262660 @default.
• W2775824694 cites W2030334534 @default.
• W2775824694 cites W2033803279 @default.
• W2775824694 cites W2033986601 @default.
• W2775824694 cites W2035855731 @default.
• W2775824694 cites W2038139095 @default.
• W2775824694 cites W2039765075 @default.
• W2775824694 cites W2039875616 @default.
• W2775824694 cites W2040031153 @default.
• W2775824694 cites W2042216712 @default.
• W2775824694 cites W2042576165 @default.
• W2775824694 cites W2042809457 @default.
• W2775824694 cites W2052201224 @default.
• W2775824694 cites W2055169705 @default.
• W2775824694 cites W2056425530 @default.
• W2775824694 cites W2056530510 @default.
• W2775824694 cites W2066226580 @default.
• W2775824694 cites W2075188232 @default.
• W2775824694 cites W2081411230 @default.
• W2775824694 cites W2081673243 @default.
• W2775824694 cites W2082219347 @default.
• W2775824694 cites W2082979850 @default.
• W2775824694 cites W2087145462 @default.
• W2775824694 cites W2087377825 @default.
• W2775824694 cites W2089141914 @default.
• W2775824694 cites W2094402871 @default.
• W2775824694 cites W2096190389 @default.
• W2775824694 cites W2096411069 @default.
• W2775824694 cites W2105230781 @default.
• W2775824694 cites W2108237056 @default.
• W2775824694 cites W2119464650 @default.
• W2775824694 cites W2120329137 @default.
• W2775824694 cites W2122795688 @default.
• W2775824694 cites W2127567657 @default.
• W2775824694 cites W2131261387 @default.
• W2775824694 cites W2132261610 @default.
• W2775824694 cites W2133938746 @default.
• W2775824694 cites W2134887638 @default.
• W2775824694 cites W2135919238 @default.
• W2775824694 cites W2135994263 @default.
• W2775824694 cites W2144625075 @default.
• W2775824694 cites W2146260726 @default.
• W2775824694 cites W2146398679 @default.
• W2775824694 cites W2152651884 @default.
• W2775824694 cites W2163953596 @default.
• W2775824694 cites W2167572981 @default.
• W2775824694 cites W2169533924 @default.
• W2775824694 cites W2171230374 @default.
• W2775824694 cites W2191103386 @default.
• W2775824694 cites W2225466805 @default.
• W2775824694 cites W2239533402 @default.
• W2775824694 cites W2309322850 @default.
• W2775824694 cites W2343841471 @default.
• W2775824694 cites W2344123412 @default.
• W2775824694 cites W2346889475 @default.
• W2775824694 doi "https://doi.org/10.1038/s41598-017-17376-0" @default.
• W2775824694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5722952" @default.
• W2775824694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29222481" @default.
• W2775824694 hasPublicationYear "2017" @default.
• W2775824694 type Work @default.
• W2775824694 sameAs 2775824694 @default.
• W2775824694 citedByCount "24" @default.
• W2775824694 countsByYear W27758246942018 @default.
• W2775824694 countsByYear W27758246942019 @default.
• W2775824694 countsByYear W27758246942020 @default.
• W2775824694 countsByYear W27758246942021 @default.
• W2775824694 countsByYear W27758246942022 @default.
• W2775824694 countsByYear W27758246942023 @default.

• next