FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775852363> ?p ?o ?g. }

• W2775852363 endingPage "86" @default.
• W2775852363 startingPage "76" @default.
• W2775852363 abstract "Fibroblast growth factor receptor-1 (FGFR1) over-expression was broadly found in squamous cancer, where it induced cellular proliferation, differentiation, and metastasis by activating various signaling pathway. However, the role of FGFR1 gene expression in predicting prognosis of Esophageal Squamous Cell Carcinoma (ESCC) and its regulatory function in the progression of ESCC are not well understood. Therefore, we performed an analysis of FGFR1 mRNA expression by quantitative RT-PCR in tumor tissue of 145 patients with ESCC. The relationships between FGFR1 gene expression and clinicopathological parameters, also the prognosis were further examined. Results suggested that higher FGFR1 gene expression predicted worse overall survival (HR = 1.502, 95%[CI] = 1.005–2.246, P = 0.045). Disease-free survival tends to be shorter in patients with higher FGFR1 expression but without statistical significance (HR = 1.398, 95%[CI] = 0.942–2.074, P = 0.096). FGFR1 was up regulated in multiple ESCC cell lines. Subsequent in vitro experiments demonstrated that anti-FGFR1 treatment by PD173074 inhibited TE-1 and EC9706 cell viability along with the attenuation of MEK-ERK signaling pathway. In vivo, PD173074 administration also had shown potent ESCC growth arresting effect. Overall, our study suggested that FGFR1 gene expression could be an independent prognosis predictive factor in patients with ESCC. Anti-FGFR1 inhibited ESCC growth and could be a potential strategy in ESCC targeted therapy." @default.
• W2775852363 created "2018-01-05" @default.
• W2775852363 creator A5006117659 @default.
• W2775852363 creator A5010431622 @default.
• W2775852363 creator A5012208123 @default.
• W2775852363 creator A5014091828 @default.
• W2775852363 creator A5027746195 @default.
• W2775852363 creator A5041976342 @default.
• W2775852363 creator A5043534663 @default.
• W2775852363 creator A5058314453 @default.
• W2775852363 creator A5074694725 @default.
• W2775852363 creator A5080704061 @default.
• W2775852363 creator A5082498438 @default.
• W2775852363 creator A5090866405 @default.
• W2775852363 date "2017-12-19" @default.
• W2775852363 modified "2023-10-16" @default.
• W2775852363 title "FGFR1 signaling potentiates tumor growth and predicts poor prognosis in esophageal squamous cell carcinoma patients" @default.
• W2775852363 cites W1545910229 @default.
• W2775852363 cites W1853436017 @default.
• W2775852363 cites W1864665074 @default.
• W2775852363 cites W1974216567 @default.
• W2775852363 cites W1974519242 @default.
• W2775852363 cites W1974789691 @default.
• W2775852363 cites W1980448975 @default.
• W2775852363 cites W1982439765 @default.
• W2775852363 cites W1988476050 @default.
• W2775852363 cites W2007442792 @default.
• W2775852363 cites W2025982984 @default.
• W2775852363 cites W2046692530 @default.
• W2775852363 cites W2055062505 @default.
• W2775852363 cites W2056983875 @default.
• W2775852363 cites W2071467611 @default.
• W2775852363 cites W2075274680 @default.
• W2775852363 cites W2081855695 @default.
• W2775852363 cites W2100502993 @default.
• W2775852363 cites W2109020001 @default.
• W2775852363 cites W2118696726 @default.
• W2775852363 cites W2133036391 @default.
• W2775852363 cites W2138645479 @default.
• W2775852363 cites W2140375000 @default.
• W2775852363 cites W2144674229 @default.
• W2775852363 cites W2153089464 @default.
• W2775852363 cites W2169752008 @default.
• W2775852363 cites W2209991874 @default.
• W2775852363 cites W2219997920 @default.
• W2775852363 cites W2229148220 @default.
• W2775852363 cites W2272263563 @default.
• W2775852363 cites W2292721782 @default.
• W2775852363 cites W2293776906 @default.
• W2775852363 cites W2521908562 @default.
• W2775852363 cites W2550856922 @default.
• W2775852363 cites W2556334837 @default.
• W2775852363 cites W2572279656 @default.
• W2775852363 cites W2594701401 @default.
• W2775852363 cites W2889657308 @default.
• W2775852363 cites W2917837889 @default.
• W2775852363 doi "https://doi.org/10.1080/15384047.2017.1394541" @default.
• W2775852363 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5790345" @default.
• W2775852363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29257923" @default.
• W2775852363 hasPublicationYear "2017" @default.
• W2775852363 type Work @default.
• W2775852363 sameAs 2775852363 @default.
• W2775852363 citedByCount "10" @default.
• W2775852363 countsByYear W27758523632019 @default.
• W2775852363 countsByYear W27758523632020 @default.
• W2775852363 countsByYear W27758523632021 @default.
• W2775852363 countsByYear W27758523632022 @default.
• W2775852363 crossrefType "journal-article" @default.
• W2775852363 hasAuthorship W2775852363A5006117659 @default.
• W2775852363 hasAuthorship W2775852363A5010431622 @default.
• W2775852363 hasAuthorship W2775852363A5012208123 @default.
• W2775852363 hasAuthorship W2775852363A5014091828 @default.
• W2775852363 hasAuthorship W2775852363A5027746195 @default.
• W2775852363 hasAuthorship W2775852363A5041976342 @default.
• W2775852363 hasAuthorship W2775852363A5043534663 @default.
• W2775852363 hasAuthorship W2775852363A5058314453 @default.
• W2775852363 hasAuthorship W2775852363A5074694725 @default.
• W2775852363 hasAuthorship W2775852363A5080704061 @default.
• W2775852363 hasAuthorship W2775852363A5082498438 @default.
• W2775852363 hasAuthorship W2775852363A5090866405 @default.
• W2775852363 hasBestOaLocation W27758523631 @default.
• W2775852363 hasConcept C104317684 @default.
• W2775852363 hasConcept C121608353 @default.
• W2775852363 hasConcept C126322002 @default.
• W2775852363 hasConcept C143998085 @default.
• W2775852363 hasConcept C150194340 @default.
• W2775852363 hasConcept C170493617 @default.
• W2775852363 hasConcept C2779013556 @default.
• W2775852363 hasConcept C2994415158 @default.
• W2775852363 hasConcept C49418065 @default.
• W2775852363 hasConcept C502942594 @default.
• W2775852363 hasConcept C54355233 @default.
• W2775852363 hasConcept C62112901 @default.
• W2775852363 hasConcept C71924100 @default.
• W2775852363 hasConcept C74373430 @default.
• W2775852363 hasConcept C86803240 @default.
• W2775852363 hasConceptScore W2775852363C104317684 @default.
• W2775852363 hasConceptScore W2775852363C121608353 @default.

• next