FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775871570> ?p ?o ?g. }

• W2775871570 endingPage "493" @default.
• W2775871570 startingPage "489" @default.
• W2775871570 abstract "The configurational space sampled by the finger and thumb subdomains of the p66 subunit of HIV-1 reverse transcriptase was investigated by Q-band double electron-electron resonance pulsed electron paramagnetic resonance spectroscopy, a method for determining long-range distances between pairs of nitroxide spin-labels introduced via surface-engineered cysteine residues. Four constructs were examined, each containing two spin-labels in the p66 subunit, one in the finger subdomain and the other in the thumb subdomain. In the unliganded state, open and closed configurations for the finger and thumb subdomains are observed with the distribution between these states modulated by the spin-labels and associated mutations, in contrast to crystallographic data in which the unliganded state crystallizes in the closed conformation. Upon addition of double-stranded DNA, all constructs adopt open conformations consistent with previous crystallographic data in which the position of the thumb and finger subdomains is determined by contacts with the bound oligonucleotide duplex (DNA or DNA/RNA). Likewise, binary complexes with five different non-nucleoside reverse transcriptase inhibitors are in open or partially open conformations, indicating that binding of the inhibitor to the palm subdomain indirectly restricts the conformational space sampled by the finger and thumb subdomains." @default.
• W2775871570 created "2018-01-05" @default.
• W2775871570 creator A5016383187 @default.
• W2775871570 creator A5024727980 @default.
• W2775871570 creator A5028974311 @default.
• W2775871570 date "2017-12-21" @default.
• W2775871570 modified "2023-09-27" @default.
• W2775871570 title "Probing Conformational States of the Finger and Thumb Subdomains of HIV-1 Reverse Transcriptase Using Double Electron–Electron Resonance Electron Paramagnetic Resonance Spectroscopy" @default.
• W2775871570 cites W1858237937 @default.
• W2775871570 cites W1895742673 @default.
• W2775871570 cites W1991492628 @default.
• W2775871570 cites W2008954911 @default.
• W2775871570 cites W2009581957 @default.
• W2775871570 cites W2011153626 @default.
• W2775871570 cites W2012603477 @default.
• W2775871570 cites W2035604051 @default.
• W2775871570 cites W2038875032 @default.
• W2775871570 cites W2040595716 @default.
• W2775871570 cites W2049618846 @default.
• W2775871570 cites W2066172986 @default.
• W2775871570 cites W2073618053 @default.
• W2775871570 cites W2077535774 @default.
• W2775871570 cites W2098513990 @default.
• W2775871570 cites W2098638598 @default.
• W2775871570 cites W2117064497 @default.
• W2775871570 cites W2133805329 @default.
• W2775871570 cites W2163102075 @default.
• W2775871570 cites W2499108023 @default.
• W2775871570 cites W2556228970 @default.
• W2775871570 cites W4234357843 @default.
• W2775871570 doi "https://doi.org/10.1021/acs.biochem.7b01035" @default.
• W2775871570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6034511" @default.
• W2775871570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29251492" @default.
• W2775871570 hasPublicationYear "2017" @default.
• W2775871570 type Work @default.
• W2775871570 sameAs 2775871570 @default.
• W2775871570 citedByCount "7" @default.
• W2775871570 countsByYear W27758715702019 @default.
• W2775871570 countsByYear W27758715702020 @default.
• W2775871570 countsByYear W27758715702021 @default.
• W2775871570 countsByYear W27758715702022 @default.
• W2775871570 crossrefType "journal-article" @default.
• W2775871570 hasAuthorship W2775871570A5016383187 @default.
• W2775871570 hasAuthorship W2775871570A5024727980 @default.
• W2775871570 hasAuthorship W2775871570A5028974311 @default.
• W2775871570 hasBestOaLocation W27758715702 @default.
• W2775871570 hasConcept C104292427 @default.
• W2775871570 hasConcept C104317684 @default.
• W2775871570 hasConcept C121332964 @default.
• W2775871570 hasConcept C126838900 @default.
• W2775871570 hasConcept C143409427 @default.
• W2775871570 hasConcept C156719811 @default.
• W2775871570 hasConcept C177462420 @default.
• W2775871570 hasConcept C185592680 @default.
• W2775871570 hasConcept C187961010 @default.
• W2775871570 hasConcept C193812863 @default.
• W2775871570 hasConcept C2910908493 @default.
• W2775871570 hasConcept C46141821 @default.
• W2775871570 hasConcept C55493867 @default.
• W2775871570 hasConcept C67705224 @default.
• W2775871570 hasConcept C71924100 @default.
• W2775871570 hasConcept C8010536 @default.
• W2775871570 hasConcept C83042744 @default.
• W2775871570 hasConceptScore W2775871570C104292427 @default.
• W2775871570 hasConceptScore W2775871570C104317684 @default.
• W2775871570 hasConceptScore W2775871570C121332964 @default.
• W2775871570 hasConceptScore W2775871570C126838900 @default.
• W2775871570 hasConceptScore W2775871570C143409427 @default.
• W2775871570 hasConceptScore W2775871570C156719811 @default.
• W2775871570 hasConceptScore W2775871570C177462420 @default.
• W2775871570 hasConceptScore W2775871570C185592680 @default.
• W2775871570 hasConceptScore W2775871570C187961010 @default.
• W2775871570 hasConceptScore W2775871570C193812863 @default.
• W2775871570 hasConceptScore W2775871570C2910908493 @default.
• W2775871570 hasConceptScore W2775871570C46141821 @default.
• W2775871570 hasConceptScore W2775871570C55493867 @default.
• W2775871570 hasConceptScore W2775871570C67705224 @default.
• W2775871570 hasConceptScore W2775871570C71924100 @default.
• W2775871570 hasConceptScore W2775871570C8010536 @default.
• W2775871570 hasConceptScore W2775871570C83042744 @default.
• W2775871570 hasFunder F4320337349 @default.
• W2775871570 hasFunder F4320337357 @default.
• W2775871570 hasIssue "5" @default.
• W2775871570 hasLocation W27758715701 @default.
• W2775871570 hasLocation W27758715702 @default.
• W2775871570 hasLocation W27758715703 @default.
• W2775871570 hasLocation W27758715704 @default.
• W2775871570 hasOpenAccess W2775871570 @default.
• W2775871570 hasPrimaryLocation W27758715701 @default.
• W2775871570 hasRelatedWork W1550269436 @default.
• W2775871570 hasRelatedWork W1978023710 @default.
• W2775871570 hasRelatedWork W2010990171 @default.
• W2775871570 hasRelatedWork W2054782803 @default.
• W2775871570 hasRelatedWork W2145982655 @default.
• W2775871570 hasRelatedWork W2287963864 @default.
• W2775871570 hasRelatedWork W2913485596 @default.
• W2775871570 hasRelatedWork W2949085716 @default.
• W2775871570 hasRelatedWork W2980737207 @default.

• next