Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775921812> ?p ?o ?g. }
- W2775921812 endingPage "1113.e6" @default.
- W2775921812 startingPage "1100" @default.
- W2775921812 abstract "Natural killer (NK) cells are present in large populations at the maternal-fetal interface during early pregnancy. However, the role of NK cells in fetal growth is unclear. Here, we have identified a CD49a+Eomes+ subset of NK cells that secreted growth-promoting factors (GPFs), including pleiotrophin and osteoglycin, in both humans and mice. The crosstalk between HLA-G and ILT2 served as a stimulus for GPF-secreting function of this NK cell subset. Decreases in this GPF-secreting NK cell subset impaired fetal development, resulting in fetal growth restriction. The transcription factor Nfil3, but not T-bet, affected the function and the number of this decidual NK cell subset. Adoptive transfer of induced CD49a+Eomes+ NK cells reversed impaired fetal growth and rebuilt an appropriate local microenvironment. These findings reveal properties of NK cells in promoting fetal growth. In addition, this research proposes approaches for therapeutic administration of NK cells in order to reverse restricted nourishments within the uterine microenvironment during early pregnancy." @default.
- W2775921812 created "2018-01-05" @default.
- W2775921812 creator A5008578743 @default.
- W2775921812 creator A5012198733 @default.
- W2775921812 creator A5013142518 @default.
- W2775921812 creator A5033420614 @default.
- W2775921812 creator A5039114229 @default.
- W2775921812 creator A5041353057 @default.
- W2775921812 creator A5073390654 @default.
- W2775921812 creator A5082411086 @default.
- W2775921812 creator A5083130438 @default.
- W2775921812 date "2017-12-01" @default.
- W2775921812 modified "2023-10-14" @default.
- W2775921812 title "Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors" @default.
- W2775921812 cites W1233202794 @default.
- W2775921812 cites W1560092366 @default.
- W2775921812 cites W1760639175 @default.
- W2775921812 cites W1776950904 @default.
- W2775921812 cites W1852086252 @default.
- W2775921812 cites W1970158367 @default.
- W2775921812 cites W1973106184 @default.
- W2775921812 cites W1982457816 @default.
- W2775921812 cites W1982831423 @default.
- W2775921812 cites W1985154369 @default.
- W2775921812 cites W1986769096 @default.
- W2775921812 cites W1987631578 @default.
- W2775921812 cites W1993565885 @default.
- W2775921812 cites W1993712744 @default.
- W2775921812 cites W1994875855 @default.
- W2775921812 cites W2006218858 @default.
- W2775921812 cites W2013435992 @default.
- W2775921812 cites W2018476521 @default.
- W2775921812 cites W2025046506 @default.
- W2775921812 cites W2025295654 @default.
- W2775921812 cites W2026445106 @default.
- W2775921812 cites W2030226183 @default.
- W2775921812 cites W2030772730 @default.
- W2775921812 cites W2031132626 @default.
- W2775921812 cites W2041044779 @default.
- W2775921812 cites W2044960250 @default.
- W2775921812 cites W2050082903 @default.
- W2775921812 cites W2052703349 @default.
- W2775921812 cites W2055144429 @default.
- W2775921812 cites W2062687768 @default.
- W2775921812 cites W2069322489 @default.
- W2775921812 cites W2080930954 @default.
- W2775921812 cites W2092134310 @default.
- W2775921812 cites W2093060517 @default.
- W2775921812 cites W2100577029 @default.
- W2775921812 cites W2103777177 @default.
- W2775921812 cites W2105155420 @default.
- W2775921812 cites W2113047034 @default.
- W2775921812 cites W2117869125 @default.
- W2775921812 cites W2124446335 @default.
- W2775921812 cites W2125334139 @default.
- W2775921812 cites W2127924037 @default.
- W2775921812 cites W2130051277 @default.
- W2775921812 cites W2138099185 @default.
- W2775921812 cites W2139614257 @default.
- W2775921812 cites W2144872368 @default.
- W2775921812 cites W2146316950 @default.
- W2775921812 cites W2158829408 @default.
- W2775921812 cites W2162646944 @default.
- W2775921812 cites W2169234390 @default.
- W2775921812 cites W2170039745 @default.
- W2775921812 cites W2170944606 @default.
- W2775921812 cites W2201213085 @default.
- W2775921812 cites W2203725537 @default.
- W2775921812 cites W2292377799 @default.
- W2775921812 cites W2321428363 @default.
- W2775921812 cites W2343948691 @default.
- W2775921812 cites W2345466072 @default.
- W2775921812 cites W2750380793 @default.
- W2775921812 cites W2759930964 @default.
- W2775921812 doi "https://doi.org/10.1016/j.immuni.2017.11.018" @default.
- W2775921812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29262349" @default.
- W2775921812 hasPublicationYear "2017" @default.
- W2775921812 type Work @default.
- W2775921812 sameAs 2775921812 @default.
- W2775921812 citedByCount "198" @default.
- W2775921812 countsByYear W27759218122018 @default.
- W2775921812 countsByYear W27759218122019 @default.
- W2775921812 countsByYear W27759218122020 @default.
- W2775921812 countsByYear W27759218122021 @default.
- W2775921812 countsByYear W27759218122022 @default.
- W2775921812 countsByYear W27759218122023 @default.
- W2775921812 crossrefType "journal-article" @default.
- W2775921812 hasAuthorship W2775921812A5008578743 @default.
- W2775921812 hasAuthorship W2775921812A5012198733 @default.
- W2775921812 hasAuthorship W2775921812A5013142518 @default.
- W2775921812 hasAuthorship W2775921812A5033420614 @default.
- W2775921812 hasAuthorship W2775921812A5039114229 @default.
- W2775921812 hasAuthorship W2775921812A5041353057 @default.
- W2775921812 hasAuthorship W2775921812A5073390654 @default.
- W2775921812 hasAuthorship W2775921812A5082411086 @default.
- W2775921812 hasAuthorship W2775921812A5083130438 @default.
- W2775921812 hasBestOaLocation W27759218121 @default.
- W2775921812 hasConcept C134018914 @default.