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- W2775952308 abstract "This study was done to evaluate the anti-hypertensive effects of stem extract of Coscinium fenestratum (CF). The stems were air dried for 2 days, grounded and then soaked in organic solvent for 2 days. Thereafter the filtered extract was concentrated using rotary evaporator at 450C to obtain the crude extract. Partial purification was done using silica gel column chromatography to separate the crude extract into five fractions A-E. The effect on hypertension was tested by intravenous injection of each extractinto a normotensive anaesthetized rat andperfused frog heart. The effect Mean Arterial Blood Pressure (MABP), Heart rate (beats per minute) (HR) and force of contraction (FOC) was recorded via the BIOPAC LAB PRO SOFTWARE. The phytochemical compound present in the extract was identified using a simple colorimetric biochemical method. The extract showed a reduction of theMABP, HR and FOC in the presence of norepinephrine and without norepinephrine. The effect of the extract was more than that of commercial drug atenolol. Colorimetric phytochemistry testing revealed the presence of flavonoids, terpenoids, saponins, tanins, cardiac glycoside and alkaloids. The effect maybe because of the type of bioactive compounds present in the extract which has previously shown antioxidant property." @default.
- W2775952308 created "2018-01-05" @default.
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- W2775952308 date "2017-11-15" @default.
- W2775952308 modified "2023-09-27" @default.
- W2775952308 title "Effect of Coscinium Fenestratum stem extracts on hypertension in animal model" @default.
- W2775952308 doi "https://doi.org/10.29269/pbb2017.v1i2.17" @default.
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