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- W2776054526 abstract "Lower muscle strength and endurance have been reported in severe obstructive sleep apnea syndrome (OSAS) patients. Increased intracortical inhibition previously reported at rest in OSAS suggests central neuromuscular impairments in these patients. This study investigated the neuromuscular mechanisms of exercise-induced fatigue in severe OSAS patients before and after an 8-week continuous positive airway pressure (CPAP) treatment. Twelve OSAS patients (age 59±7 yrs; BMI 27±3 kg·m−2; AHI 46±13 events·h−1) and 11 matched controls were included. Maximal voluntary contraction (MVC), voluntary activation (VA) levels assessed by femoral nerve electrical stimulation (FNES) and transcranial magnetic stimulation (TMS) and intracortical inhibition parameters were measured before and during a fatiguing task (FT: repeated isometric knee extensions) until exhaustion. Time to exhaustion was lower in OSAS patients compared to controls (991±461 vs 1375±583s, p=0.017). MVC (138±49 vs 157±49 N·m, p=0.004), VAFNES (86±10 vs 89±8%, p=0.022) and VATMS (86±16 vs 91±7%, p=0.049) were lower in OSAS patients before and during FT. Cortical silent period duration (quadriceps muscles: 225±54 vs 194±47ms at 35%MVC, p This study demonstrates that severe OSAS patients have reduced knee extensors strength and endurance possibly due to central activation deficit and increased intracortical inhibition. An 8-week CPAP treatment did not reverse these neuromuscular impairments." @default.
- W2776054526 created "2018-01-05" @default.
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- W2776054526 date "2017-09-01" @default.
- W2776054526 modified "2023-10-16" @default.
- W2776054526 title "Reduced voluntary activation and increased intracortical inhibition during leg extensions in severe obstructive sleep apnoea patients" @default.
- W2776054526 doi "https://doi.org/10.1183/1393003.congress-2017.oa3432" @default.
- W2776054526 hasPublicationYear "2017" @default.
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