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- W2776115114 abstract "Background: Thrombolytic therapy is considered to be the most effective treatment for high risk/life-threatening PE, and could also be effective for some intermediate risk PE with right ventricular dysfunction and/or myocardial. In this study, we aimed to evaluate the long-term efficacy and safety of half-dose recombinant tissue plasminogen activator (rt-PA) in PE treatment. Materials and Methods: 96 patients with the diagnosis of massive or submassive PE, who had thrombolytic therapy were evaluated retrospectively. 46 patients who were treated with 50 mg/1 hour (h) rt-PA were included in the study group. In the control group, 46 patients who treated with 100mg/2 h intravenous infusion of rt-PA were included. All patients were evaluated for radiological findings, echocardiographic changes, PE recurrence, chronic PE, and all-cause mortality. Result: There were no significant differences between the groups in terms of demographic data, the type of embolism, average symptom durations, initial systolic pulmonary artery pressures (sPAP) and oxygen saturation values, D-Dimer and troponin (p> 0.05). There was no difference between groups in terms of mortality rates in the first month and after the first year of treatment (p = 0.384, p = 1.000, respectively). Fifth year survival rates were similar between the groups (p> 0.05). Conclusion: It is considered that with half-dose treatment and reduced bleeding complications and also with sharing data that is indicating the same efficacy, the optimal therapeutic dose may change in the future." @default.
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- W2776115114 date "2017-09-01" @default.
- W2776115114 modified "2023-09-23" @default.
- W2776115114 title "Half - dose of recombinant tissue-type plasminogen activator in the treatment of acute pulmonary embolism: long term outcomes" @default.
- W2776115114 doi "https://doi.org/10.1183/1393003.congress-2017.pa565" @default.
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