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• W2776170457 abstract "This study aimed at analyzing the frequency of micronuclei (MN) in exfoliated cells as well as the levels of Pb-210 in urine samples to evaluate the association between the smoking habit and toxic stress of transitional epithelial cells. The frequency of MN was scored from Giemsa-stained slides while exchange resin and beta counting techniques were employed to measure the concentrations of this radioisotope. Urine samples of smokers had levels of Pb-210 up to 158.65 mBq L−1. For nonsmokers, the median was below the detection limit (45 mBq L−1). The analyses of mononucleated cells showed a significant increase of the frequency of MN in smokers when compared to nonsmokers. Statistical tests showed a tight relation between the cigarette consumption and the increase of the frequency of MN, rather than with the levels of Pb-210 present in smoke particles. The results indicate the usefulness of the methodology for the evaluation of human health risks related to chronic contamination with Pb-210." @default.
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• W2776170457 date "2018-01-01" @default.
• W2776170457 modified "2023-10-02" @default.
• W2776170457 title "Evaluation of Pb-210 in urine and frequency of micronuclei in exfoliated cells as indicators of exposure to cigarettes" @default.
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• W2776170457 doi "https://doi.org/10.1016/j.mrgentox.2017.12.007" @default.
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