Matches in SemOpenAlex for { <https://semopenalex.org/work/W2776173859> ?p ?o ?g. }
- W2776173859 endingPage "T60" @default.
- W2776173859 startingPage "T45" @default.
- W2776173859 abstract "The insulin-like growth factor (IGF) system has gained substantial interest due to its involvement in regulating cell proliferation, differentiation and survival during anoikis and after conventional and targeted therapies. However, results from clinical trials have been largely disappointing, with only a few but notable exceptions, such as trials targeting sarcomas, especially Ewing sarcoma. This review highlights key studies focusing on IGF signaling in sarcomas, specifically studies underscoring the properties that make this system an attractive therapeutic target and identifies new relationships that may be exploited. This review discusses the potential roles of IGF2 mRNA-binding proteins (IGF2BPs), discoidin domain receptors (DDRs) and metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) in regulating the IGF system. Deeper investigation of these novel regulators of the IGF system may help us to further elucidate the spatial and temporal control of the IGF axis, as understanding the control of this axis is essential for future clinical studies." @default.
- W2776173859 created "2018-01-05" @default.
- W2776173859 creator A5015636061 @default.
- W2776173859 creator A5090686010 @default.
- W2776173859 date "2018-07-01" @default.
- W2776173859 modified "2023-10-15" @default.
- W2776173859 title "40 YEARS OF IGF1: IGF system in sarcomas: a crucial pathway with many unknowns to exploit for therapy" @default.
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