Matches in SemOpenAlex for { <https://semopenalex.org/work/W2776243693> ?p ?o ?g. }
- W2776243693 endingPage "462" @default.
- W2776243693 startingPage "453" @default.
- W2776243693 abstract "Signal transduction plays important roles in biological systems. Unfortunately, our knowledge about signaling pathways is far from complete. Specifically, the direction of signaling flows is less known even though the signaling molecules of some signaling pathways have been determined. In this paper, we propose a novel hybrid intelligent method, namely HISP (Hybrid Intelligent approach for identifying directed Signaling Pathways), to determine both the topologies of signaling pathways and the direction of signaling flows within a pathway based on integer linear programming and genetic algorithm. By integrating the protein-protein interaction, gene expression, and gene knockout data, our HISP approach is able to determine the optimal topologies of signaling pathways in an accurate way. Benchmark results on yeast MAPK signaling pathways demonstrate the efficiency of our proposed approach. When applied to the EGFR/ErbB signaling pathway in human hepatocytes, HISP unveils a high-resolution signaling pathway, where many signaling interactions were missing by existing computational approaches." @default.
- W2776243693 created "2018-01-05" @default.
- W2776243693 creator A5004366207 @default.
- W2776243693 creator A5049435754 @default.
- W2776243693 date "2017-12-01" @default.
- W2776243693 modified "2023-10-18" @default.
- W2776243693 title "HISP: a hybrid intelligent approach for identifying directed signaling pathways" @default.
- W2776243693 cites W1524141331 @default.
- W2776243693 cites W1807981783 @default.
- W2776243693 cites W1855299742 @default.
- W2776243693 cites W1921176196 @default.
- W2776243693 cites W1953744040 @default.
- W2776243693 cites W1964414267 @default.
- W2776243693 cites W1975857636 @default.
- W2776243693 cites W1978303592 @default.
- W2776243693 cites W1986364415 @default.
- W2776243693 cites W1986827304 @default.
- W2776243693 cites W1998031633 @default.
- W2776243693 cites W2000805552 @default.
- W2776243693 cites W2022192839 @default.
- W2776243693 cites W2024784927 @default.
- W2776243693 cites W2028133290 @default.
- W2776243693 cites W2029800573 @default.
- W2776243693 cites W2067803871 @default.
- W2776243693 cites W2068681052 @default.
- W2776243693 cites W2070066745 @default.
- W2776243693 cites W2073307618 @default.
- W2776243693 cites W2081713084 @default.
- W2776243693 cites W2088933296 @default.
- W2776243693 cites W2097283846 @default.
- W2776243693 cites W2099660028 @default.
- W2776243693 cites W2102748451 @default.
- W2776243693 cites W2105032127 @default.
- W2776243693 cites W2110095004 @default.
- W2776243693 cites W2110687686 @default.
- W2776243693 cites W2115185739 @default.
- W2776243693 cites W2119109240 @default.
- W2776243693 cites W2126249571 @default.
- W2776243693 cites W2129960784 @default.
- W2776243693 cites W2133300954 @default.
- W2776243693 cites W2136303131 @default.
- W2776243693 cites W2137361456 @default.
- W2776243693 cites W2137683543 @default.
- W2776243693 cites W2140469676 @default.
- W2776243693 cites W2144107676 @default.
- W2776243693 cites W2145899141 @default.
- W2776243693 cites W2146264532 @default.
- W2776243693 cites W2154082641 @default.
- W2776243693 cites W2157937554 @default.
- W2776243693 cites W2161682775 @default.
- W2776243693 cites W2165674132 @default.
- W2776243693 cites W2172049947 @default.
- W2776243693 cites W2426535589 @default.
- W2776243693 cites W2602965346 @default.
- W2776243693 cites W4294216483 @default.
- W2776243693 doi "https://doi.org/10.1093/jmcb/mjx054" @default.
- W2776243693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29281081" @default.
- W2776243693 hasPublicationYear "2017" @default.
- W2776243693 type Work @default.
- W2776243693 sameAs 2776243693 @default.
- W2776243693 citedByCount "15" @default.
- W2776243693 countsByYear W27762436932018 @default.
- W2776243693 countsByYear W27762436932019 @default.
- W2776243693 countsByYear W27762436932021 @default.
- W2776243693 countsByYear W27762436932022 @default.
- W2776243693 countsByYear W27762436932023 @default.
- W2776243693 crossrefType "journal-article" @default.
- W2776243693 hasAuthorship W2776243693A5004366207 @default.
- W2776243693 hasAuthorship W2776243693A5049435754 @default.
- W2776243693 hasBestOaLocation W27762436931 @default.
- W2776243693 hasConcept C104317684 @default.
- W2776243693 hasConcept C111919701 @default.
- W2776243693 hasConcept C150194340 @default.
- W2776243693 hasConcept C150555746 @default.
- W2776243693 hasConcept C161879069 @default.
- W2776243693 hasConcept C199845137 @default.
- W2776243693 hasConcept C41008148 @default.
- W2776243693 hasConcept C54355233 @default.
- W2776243693 hasConcept C62478195 @default.
- W2776243693 hasConcept C65114990 @default.
- W2776243693 hasConcept C70721500 @default.
- W2776243693 hasConcept C86803240 @default.
- W2776243693 hasConcept C95444343 @default.
- W2776243693 hasConcept C9927688 @default.
- W2776243693 hasConceptScore W2776243693C104317684 @default.
- W2776243693 hasConceptScore W2776243693C111919701 @default.
- W2776243693 hasConceptScore W2776243693C150194340 @default.
- W2776243693 hasConceptScore W2776243693C150555746 @default.
- W2776243693 hasConceptScore W2776243693C161879069 @default.
- W2776243693 hasConceptScore W2776243693C199845137 @default.
- W2776243693 hasConceptScore W2776243693C41008148 @default.
- W2776243693 hasConceptScore W2776243693C54355233 @default.
- W2776243693 hasConceptScore W2776243693C62478195 @default.
- W2776243693 hasConceptScore W2776243693C65114990 @default.
- W2776243693 hasConceptScore W2776243693C70721500 @default.
- W2776243693 hasConceptScore W2776243693C86803240 @default.
- W2776243693 hasConceptScore W2776243693C95444343 @default.
- W2776243693 hasConceptScore W2776243693C9927688 @default.