FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2776273648> ?p ?o ?g. }

• W2776273648 endingPage "e018328" @default.
• W2776273648 startingPage "e018328" @default.
• W2776273648 abstract "Objectives The objective was to develop and validate a risk model for the likelihood of extensive white matter lesions (extWML) to inform clinicians on whether to proceed with or forgo diagnostic MRI. Design Population-based cohort study and multivariable prediction model. Setting Two representative samples from France. Participants Persons aged 60–80 years without dementia or stroke. Derivation sample n=1714; validation sample n=789. Primary and secondary outcome measures Volume of extWML (log cm 3 ) was obtained from T2-weighted images in a 1.5 T scanner. 20 candidate risk factors for extWML were evaluated with the C-statistic. Secondary outcomes in validation included incident stroke over 12 years follow-up. Results The multivariable prediction model included six clinical risk factors (C-statistic=0.61). A cut-off of 7 points on the multivariable prediction model yielded the optimum balance in sensitivity 63.7% and specificity 54.0% and the negative predictive value was high (81.8%), but the positive predictive value was low (31.5%). In further validation, incident stroke risk was associated with continuous scores on the multivariable prediction model (HR 1.02; 95% CI 1.01 to 1.04, P=0.02) and dichotomised scores from the multivariable prediction model (HR 1.28; 95% CI 1.02 to 1.60, P=0.03). Conclusions A simple clinical risk equation for WML constituted by six variables can inform decisions whether to proceed with or forgo brain MRI. The high-negative predictive value demonstrates potential to reduce unnecessary MRI in the population aged 60–80 years." @default.
• W2776273648 created "2018-01-05" @default.
• W2776273648 creator A5023050610 @default.
• W2776273648 creator A5040742305 @default.
• W2776273648 creator A5052944986 @default.
• W2776273648 creator A5056934319 @default.
• W2776273648 creator A5073720189 @default.
• W2776273648 creator A5077569991 @default.
• W2776273648 date "2017-12-01" @default.
• W2776273648 modified "2023-10-13" @default.
• W2776273648 title "Development and validation of a priori risk model for extensive white matter lesions in people age 65 years or older: the Dijon MRI study" @default.
• W2776273648 cites W1485897525 @default.
• W2776273648 cites W1499745034 @default.
• W2776273648 cites W1552844714 @default.
• W2776273648 cites W1553296741 @default.
• W2776273648 cites W1959912882 @default.
• W2776273648 cites W1973151657 @default.
• W2776273648 cites W1975666523 @default.
• W2776273648 cites W1997794971 @default.
• W2776273648 cites W2000736071 @default.
• W2776273648 cites W2004574727 @default.
• W2776273648 cites W2006742792 @default.
• W2776273648 cites W2006940889 @default.
• W2776273648 cites W2008273493 @default.
• W2776273648 cites W2020753774 @default.
• W2776273648 cites W2035892177 @default.
• W2776273648 cites W2037195555 @default.
• W2776273648 cites W2055879382 @default.
• W2776273648 cites W2059104398 @default.
• W2776273648 cites W2060708122 @default.
• W2776273648 cites W2063721328 @default.
• W2776273648 cites W2071837886 @default.
• W2776273648 cites W2077576767 @default.
• W2776273648 cites W2081547922 @default.
• W2776273648 cites W2091163929 @default.
• W2776273648 cites W2091754708 @default.
• W2776273648 cites W2113770731 @default.
• W2776273648 cites W2131078911 @default.
• W2776273648 cites W2139186101 @default.
• W2776273648 cites W2143387951 @default.
• W2776273648 cites W2144971762 @default.
• W2776273648 cites W2153922623 @default.
• W2776273648 cites W2157825442 @default.
• W2776273648 cites W2165566667 @default.
• W2776273648 cites W2308026263 @default.
• W2776273648 cites W2319016177 @default.
• W2776273648 cites W2324276018 @default.
• W2776273648 cites W2338681188 @default.
• W2776273648 cites W2490309505 @default.
• W2776273648 cites W2544444450 @default.
• W2776273648 cites W2602374858 @default.
• W2776273648 cites W4233026002 @default.
• W2776273648 cites W4244273072 @default.
• W2776273648 doi "https://doi.org/10.1136/bmjopen-2017-018328" @default.
• W2776273648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5778304" @default.
• W2776273648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29289936" @default.
• W2776273648 hasPublicationYear "2017" @default.
• W2776273648 type Work @default.
• W2776273648 sameAs 2776273648 @default.
• W2776273648 citedByCount "4" @default.
• W2776273648 countsByYear W27762736482018 @default.
• W2776273648 countsByYear W27762736482019 @default.
• W2776273648 countsByYear W27762736482020 @default.
• W2776273648 crossrefType "journal-article" @default.
• W2776273648 hasAuthorship W2776273648A5023050610 @default.
• W2776273648 hasAuthorship W2776273648A5040742305 @default.
• W2776273648 hasAuthorship W2776273648A5052944986 @default.
• W2776273648 hasAuthorship W2776273648A5056934319 @default.
• W2776273648 hasAuthorship W2776273648A5073720189 @default.
• W2776273648 hasAuthorship W2776273648A5077569991 @default.
• W2776273648 hasBestOaLocation W27762736481 @default.
• W2776273648 hasConcept C105795698 @default.
• W2776273648 hasConcept C117312493 @default.
• W2776273648 hasConcept C11783203 @default.
• W2776273648 hasConcept C126322002 @default.
• W2776273648 hasConcept C127413603 @default.
• W2776273648 hasConcept C133731056 @default.
• W2776273648 hasConcept C198433322 @default.
• W2776273648 hasConcept C2779134260 @default.
• W2776273648 hasConcept C2780645631 @default.
• W2776273648 hasConcept C2908647359 @default.
• W2776273648 hasConcept C33923547 @default.
• W2776273648 hasConcept C71924100 @default.
• W2776273648 hasConcept C78519656 @default.
• W2776273648 hasConcept C89128539 @default.
• W2776273648 hasConcept C99454951 @default.
• W2776273648 hasConceptScore W2776273648C105795698 @default.
• W2776273648 hasConceptScore W2776273648C117312493 @default.
• W2776273648 hasConceptScore W2776273648C11783203 @default.
• W2776273648 hasConceptScore W2776273648C126322002 @default.
• W2776273648 hasConceptScore W2776273648C127413603 @default.
• W2776273648 hasConceptScore W2776273648C133731056 @default.
• W2776273648 hasConceptScore W2776273648C198433322 @default.
• W2776273648 hasConceptScore W2776273648C2779134260 @default.
• W2776273648 hasConceptScore W2776273648C2780645631 @default.
• W2776273648 hasConceptScore W2776273648C2908647359 @default.
• W2776273648 hasConceptScore W2776273648C33923547 @default.
• W2776273648 hasConceptScore W2776273648C71924100 @default.

• next