FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2776423694> ?p ?o ?g. }

• W2776423694 endingPage "736" @default.
• W2776423694 startingPage "722" @default.
• W2776423694 abstract "The zinc-finger protein tristetraprolin (TTP) binds to AU-rich elements present in the 3′ untranslated regions of transcripts that mainly encode proteins of the inflammatory response. TTP-bound mRNAs are targeted for destruction via recruitment of the eight-subunit deadenylase complex “carbon catabolite repressor protein 4 (CCR4)-negative on TATA-less (NOT),” which catalyzes the removal of mRNA poly-(A) tails, the first obligatory step in mRNA decay. Here we show that a novel interaction between TTP and the CCR4-NOT subunit, CNOT9, is required for recruitment of the deadenylase complex. In addition to CNOT1, CNOT9 is now included in the identified CCR4-NOT subunits shown to interact with TTP. We find that both the N- and C-terminal domains of TTP are involved in an interaction with CNOT9. Through a combination of SPOT peptide array, site-directed mutagenesis, and bio-layer interferometry, we identified several conserved tryptophan residues in TTP that serve as major sites of interaction with two tryptophan-binding pockets of CNOT9, previously found to interact with another modulator GW182. We further demonstrate that these interactions are also required for recruitment of the CCR4-NOT complex and TTP-directed decay of an mRNA containing an AU-rich element in its 3′-untranslated region. Together the results reveal new molecular details for the TTP-CNOT interaction that shape an emerging mechanism whereby TTP targets inflammatory mRNAs for deadenylation and decay." @default.
• W2776423694 created "2018-01-05" @default.
• W2776423694 creator A5002139934 @default.
• W2776423694 creator A5007099632 @default.
• W2776423694 creator A5022690614 @default.
• W2776423694 creator A5025427551 @default.
• W2776423694 creator A5025765625 @default.
• W2776423694 creator A5034393535 @default.
• W2776423694 creator A5041698971 @default.
• W2776423694 creator A5042026280 @default.
• W2776423694 creator A5053762784 @default.
• W2776423694 creator A5060952835 @default.
• W2776423694 creator A5061754600 @default.
• W2776423694 creator A5065027688 @default.
• W2776423694 creator A5074758586 @default.
• W2776423694 creator A5078144123 @default.
• W2776423694 creator A5080973071 @default.
• W2776423694 creator A5083275064 @default.
• W2776423694 date "2018-03-01" @default.
• W2776423694 modified "2023-10-03" @default.
• W2776423694 title "Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment" @default.
• W2776423694 cites W1739362983 @default.
• W2776423694 cites W1977919304 @default.
• W2776423694 cites W1978054108 @default.
• W2776423694 cites W1996157637 @default.
• W2776423694 cites W2015344893 @default.
• W2776423694 cites W2025410059 @default.
• W2776423694 cites W2045714098 @default.
• W2776423694 cites W2049456288 @default.
• W2776423694 cites W2052991419 @default.
• W2776423694 cites W2057532472 @default.
• W2776423694 cites W2057604708 @default.
• W2776423694 cites W2068054277 @default.
• W2776423694 cites W2076592490 @default.
• W2776423694 cites W2078493328 @default.
• W2776423694 cites W2085434406 @default.
• W2776423694 cites W2091326252 @default.
• W2776423694 cites W2094252079 @default.
• W2776423694 cites W2098775968 @default.
• W2776423694 cites W2106947895 @default.
• W2776423694 cites W2123524671 @default.
• W2776423694 cites W2127264152 @default.
• W2776423694 cites W2129377911 @default.
• W2776423694 cites W2129649868 @default.
• W2776423694 cites W2134496526 @default.
• W2776423694 cites W2134692718 @default.
• W2776423694 cites W2135225987 @default.
• W2776423694 cites W2146763669 @default.
• W2776423694 cites W2148915104 @default.
• W2776423694 cites W2152006080 @default.
• W2776423694 cites W2155905959 @default.
• W2776423694 cites W2161820095 @default.
• W2776423694 cites W2166919944 @default.
• W2776423694 cites W2169095006 @default.
• W2776423694 cites W4293247451 @default.
• W2776423694 doi "https://doi.org/10.1016/j.jmb.2017.12.018" @default.
• W2776423694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29291391" @default.
• W2776423694 hasPublicationYear "2018" @default.
• W2776423694 type Work @default.
• W2776423694 sameAs 2776423694 @default.
• W2776423694 citedByCount "33" @default.
• W2776423694 countsByYear W27764236942018 @default.
• W2776423694 countsByYear W27764236942019 @default.
• W2776423694 countsByYear W27764236942020 @default.
• W2776423694 countsByYear W27764236942021 @default.
• W2776423694 countsByYear W27764236942022 @default.
• W2776423694 countsByYear W27764236942023 @default.
• W2776423694 crossrefType "journal-article" @default.
• W2776423694 hasAuthorship W2776423694A5002139934 @default.
• W2776423694 hasAuthorship W2776423694A5007099632 @default.
• W2776423694 hasAuthorship W2776423694A5022690614 @default.
• W2776423694 hasAuthorship W2776423694A5025427551 @default.
• W2776423694 hasAuthorship W2776423694A5025765625 @default.
• W2776423694 hasAuthorship W2776423694A5034393535 @default.
• W2776423694 hasAuthorship W2776423694A5041698971 @default.
• W2776423694 hasAuthorship W2776423694A5042026280 @default.
• W2776423694 hasAuthorship W2776423694A5053762784 @default.
• W2776423694 hasAuthorship W2776423694A5060952835 @default.
• W2776423694 hasAuthorship W2776423694A5061754600 @default.
• W2776423694 hasAuthorship W2776423694A5065027688 @default.
• W2776423694 hasAuthorship W2776423694A5074758586 @default.
• W2776423694 hasAuthorship W2776423694A5078144123 @default.
• W2776423694 hasAuthorship W2776423694A5080973071 @default.
• W2776423694 hasAuthorship W2776423694A5083275064 @default.
• W2776423694 hasBestOaLocation W27764236942 @default.
• W2776423694 hasConcept C104292427 @default.
• W2776423694 hasConcept C104317684 @default.
• W2776423694 hasConcept C105580179 @default.
• W2776423694 hasConcept C107824862 @default.
• W2776423694 hasConcept C11804247 @default.
• W2776423694 hasConcept C143425029 @default.
• W2776423694 hasConcept C158448853 @default.
• W2776423694 hasConcept C185592680 @default.
• W2776423694 hasConcept C2776630724 @default.
• W2776423694 hasConcept C2779012473 @default.
• W2776423694 hasConcept C2909367411 @default.
• W2776423694 hasConcept C54355233 @default.
• W2776423694 hasConcept C552990157 @default.

• next