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• W2776429196 abstract "Recently, we have shown that the administration of the tumour-targeted antibody-based immunocytokine L19-IL2 after radiotherapy (RT) resulted in synergistic anti-tumour effect. Here we show that RT and L19-IL2 can activate a curative abscopal effect, with a long-lasting immunological memory. Ionizing radiation (single dose of 15Gy, 5 × 2Gy or 5 × 5Gy) was delivered to primary C51 colon tumour-bearing immunocompetent mice in combination with L19-IL2 and response of secondary non-irradiated C51 or CT26 colon tumours was evaluated. 15Gy + L19-IL2 triggered a curative (20%) abscopal effect, which was T cell dependent. Moreover, 10Gy + L19-IL2 treated and cured mice were re-injected after 150 days with C51 tumour cells and tumour uptake was assessed. Age-matched controls (matrigel injected mice treated with 10Gy + L19-IL2, mice cured after treatment with surgery + L19-IL2 and mice cured after high dose RT 40Gy + vehicle) were included. Several immunological parameters in blood, tumours, lymph nodes and spleens were investigated. Treatment with 10Gy + L19-IL2 resulted in long-lasting immunological memory, associated with CD44+CD127+ expression on circulating T cells. This combination treatment can induce long-lasting curative abscopal responses, and therefore it has also great potential for treatment of metastatic disease. Preclinical findings have led to the initiation of a phase I clinical trial (NCT02086721) in our institute investigating stereotactic ablative radiotherapy with L19-IL2 in patients with oligometastatic solid tumours." @default.
• W2776429196 created "2018-01-05" @default.
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• W2776429196 date "2018-01-16" @default.
• W2776429196 modified "2023-10-13" @default.
• W2776429196 title "The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses" @default.
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• W2776429196 doi "https://doi.org/10.1080/2162402x.2017.1414119" @default.
• W2776429196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5889197" @default.
• W2776429196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29632732" @default.
• W2776429196 hasPublicationYear "2018" @default.
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