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• W2776433312 abstract "Many mammals are well adapted to surviving in extremely cold environments. These species have likely accumulated genetic changes that help them efficiently cope with low temperatures. It is not known whether the same genes related to cold adaptation in one species would be under selection in another species. The aims of this study therefore were: to create a compendium of mammalian genes related to adaptations to a low temperature environment; to identify genes related to cold tolerance that have been subjected to independent positive selection in several species; to determine promising candidate genes/pathways/organs for further empirical research on cold adaptation in mammals.After a search for publications containing keywords: whole genome, transcriptome or exome sequencing data, and genome-wide genotyping array data authors looked for information related to genetic signatures ascribable to positive selection in Arctic or Antarctic mammalian species. Publications related to Human, Arctic fox, Yakut horse, Mammoth, Polar bear, and Minke whale were chosen. The compendium of genes that potentially underwent positive selection in >1 of these six species consisted of 416 genes. Twelve of them showed traces of positive selection in three species. Gene ontology term enrichment analysis of 416 genes from the compendium has revealed 13 terms relevant to the scope of this study. We found that enriched terms were relevant to three major groups: terms associated with collagen proteins and the extracellular matrix; terms associated with the anatomy and physiology of cilium; terms associated with docking. We further revealed that genes from compendium were over-represented in the lists of genes expressed in the lung and liver.A compendium combining mammalian genes involved in adaptation to cold environment was designed, based on the intersection of positively selected genes from six Arctic and Antarctic species. The compendium contained 416 genes that have been positively selected in at least two species. However, we did not reveal any positively selected genes that would be related to cold adaptation in all species from our list. But, our work points to several strong candidate genes involved in mechanisms and biochemical pathways related to cold adaptation response in different species." @default.
• W2776433312 created "2018-01-05" @default.
• W2776433312 creator A5042500646 @default.
• W2776433312 creator A5074812838 @default.
• W2776433312 creator A5075720865 @default.
• W2776433312 date "2017-12-01" @default.
• W2776433312 modified "2023-10-09" @default.
• W2776433312 title "A compendium and functional characterization of mammalian genes involved in adaptation to Arctic or Antarctic environments" @default.
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• W2776433312 doi "https://doi.org/10.1186/s12863-017-0580-9" @default.
• W2776433312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5751660" @default.

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