FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2776531405> ?p ?o ?g. }

• W2776531405 endingPage "e322" @default.
• W2776531405 startingPage "e316" @default.
• W2776531405 abstract "Objective While clinical benefit from thrombolysis decreases with increase in time from stroke onset, the relationship of acute physiologic tissue compartments and collateral response to stroke onset time remains unclear. Methods We studied consecutive patients with proximal arterial occlusions (n = 355) with whole-brain perfusion CT with CT angiography within 6 hours of stroke onset. Penumbra and core were defined using voxel-based thresholds. Tissue mismatch was defined as the ratio of penumbra to core. Collateral scores were assessed using a previously validated visual score. Results Mean (SD) age was 72.1 (12.4) years, median (interquartile range) NIH Stroke Scale score 16 (4), mean (SD) time to imaging 152.5 (69.7) minutes. Penumbra volume (Spearman ρ = 0.119, p = 0.026) and mismatch increased (Spearman ρ = 0.115, p = 0.030) with time from onset. Core volume decreased (Spearman ρ = −0.112, p = 0.035) while collateral scores increased with time (Spearman ρ = 0.117, p = 0.028). On multivariable regression, good collateral scores predicted longer time since onset (β = 0.101, p = 0.039) while mismatch was not a predictor (β = 0.001, p = 0.351). Good collateral score was the strongest independent predictor of final infarct volume and improvement in clinical deficit. Conclusions In our large patient cohort study of proximal arterial occlusions, we found an incremental collateral response and preserved penumbral volume with time. Thus, tissue viability can be maintained in this time window (0–6 hours) after stroke if leptomeningeal collaterals are able to sustain the penumbra. Our findings suggest that a longer therapeutic window may exist for intra-arterial intervention and that multimodal imaging may have a role in strokes of unknown onset time." @default.
• W2776531405 created "2018-01-05" @default.
• W2776531405 creator A5003437570 @default.
• W2776531405 creator A5016966768 @default.
• W2776531405 creator A5035579916 @default.
• W2776531405 creator A5061534662 @default.
• W2776531405 creator A5069550548 @default.
• W2776531405 date "2017-12-27" @default.
• W2776531405 modified "2023-10-18" @default.
• W2776531405 title "Collateral response modulates the time–penumbra relationship in proximal arterial occlusions" @default.
• W2776531405 cites W1965655136 @default.
• W2776531405 cites W1965968585 @default.
• W2776531405 cites W1988591730 @default.
• W2776531405 cites W1990215257 @default.
• W2776531405 cites W1999917076 @default.
• W2776531405 cites W2008838868 @default.
• W2776531405 cites W2014574723 @default.
• W2776531405 cites W2014889333 @default.
• W2776531405 cites W2027185363 @default.
• W2776531405 cites W2048838079 @default.
• W2776531405 cites W2062047217 @default.
• W2776531405 cites W2080370764 @default.
• W2776531405 cites W2081117549 @default.
• W2776531405 cites W2082291642 @default.
• W2776531405 cites W2085738769 @default.
• W2776531405 cites W2086758120 @default.
• W2776531405 cites W2094728278 @default.
• W2776531405 cites W2096971175 @default.
• W2776531405 cites W2102638919 @default.
• W2776531405 cites W2104657667 @default.
• W2776531405 cites W2119542322 @default.
• W2776531405 cites W2121300729 @default.
• W2776531405 cites W2133514192 @default.
• W2776531405 cites W2134410543 @default.
• W2776531405 cites W2138157900 @default.
• W2776531405 cites W2152705022 @default.
• W2776531405 cites W2171165037 @default.
• W2776531405 cites W2260335648 @default.
• W2776531405 cites W2559592568 @default.
• W2776531405 cites W3003174021 @default.
• W2776531405 cites W4210756097 @default.
• W2776531405 cites W4242649591 @default.
• W2776531405 doi "https://doi.org/10.1212/wnl.0000000000004858" @default.
• W2776531405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29282332" @default.
• W2776531405 hasPublicationYear "2017" @default.
• W2776531405 type Work @default.
• W2776531405 sameAs 2776531405 @default.
• W2776531405 citedByCount "35" @default.
• W2776531405 countsByYear W27765314052017 @default.
• W2776531405 countsByYear W27765314052018 @default.
• W2776531405 countsByYear W27765314052019 @default.
• W2776531405 countsByYear W27765314052020 @default.
• W2776531405 countsByYear W27765314052021 @default.
• W2776531405 countsByYear W27765314052022 @default.
• W2776531405 countsByYear W27765314052023 @default.
• W2776531405 crossrefType "journal-article" @default.
• W2776531405 hasAuthorship W2776531405A5003437570 @default.
• W2776531405 hasAuthorship W2776531405A5016966768 @default.
• W2776531405 hasAuthorship W2776531405A5035579916 @default.
• W2776531405 hasAuthorship W2776531405A5061534662 @default.
• W2776531405 hasAuthorship W2776531405A5069550548 @default.
• W2776531405 hasConcept C119060515 @default.
• W2776531405 hasConcept C126322002 @default.
• W2776531405 hasConcept C126838900 @default.
• W2776531405 hasConcept C127413603 @default.
• W2776531405 hasConcept C146957229 @default.
• W2776531405 hasConcept C164705383 @default.
• W2776531405 hasConcept C2776599846 @default.
• W2776531405 hasConcept C2779581417 @default.
• W2776531405 hasConcept C2780577055 @default.
• W2776531405 hasConcept C2780645631 @default.
• W2776531405 hasConcept C2989005 @default.
• W2776531405 hasConcept C500558357 @default.
• W2776531405 hasConcept C541997718 @default.
• W2776531405 hasConcept C71924100 @default.
• W2776531405 hasConcept C78519656 @default.
• W2776531405 hasConceptScore W2776531405C119060515 @default.
• W2776531405 hasConceptScore W2776531405C126322002 @default.
• W2776531405 hasConceptScore W2776531405C126838900 @default.
• W2776531405 hasConceptScore W2776531405C127413603 @default.
• W2776531405 hasConceptScore W2776531405C146957229 @default.
• W2776531405 hasConceptScore W2776531405C164705383 @default.
• W2776531405 hasConceptScore W2776531405C2776599846 @default.
• W2776531405 hasConceptScore W2776531405C2779581417 @default.
• W2776531405 hasConceptScore W2776531405C2780577055 @default.
• W2776531405 hasConceptScore W2776531405C2780645631 @default.
• W2776531405 hasConceptScore W2776531405C2989005 @default.
• W2776531405 hasConceptScore W2776531405C500558357 @default.
• W2776531405 hasConceptScore W2776531405C541997718 @default.
• W2776531405 hasConceptScore W2776531405C71924100 @default.
• W2776531405 hasConceptScore W2776531405C78519656 @default.
• W2776531405 hasIssue "4" @default.
• W2776531405 hasLocation W27765314051 @default.
• W2776531405 hasLocation W27765314052 @default.
• W2776531405 hasOpenAccess W2776531405 @default.
• W2776531405 hasPrimaryLocation W27765314051 @default.
• W2776531405 hasRelatedWork W2001287456 @default.
• W2776531405 hasRelatedWork W2100799366 @default.

• next