FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2776538095> ?p ?o ?g. }

• W2776538095 endingPage "117" @default.
• W2776538095 startingPage "103" @default.
• W2776538095 abstract "Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet, no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin in combination (G-003M) on ionising radiation induced GI injury. We prophylactically administered G-003M to C57BL/6J mice exposed to 9 Gy total body radiation (TBI) and assessed for morphological changes, loss in absorption, fluid retention, biochemical alterations, immunohistochemical analysis to study cPARP, caspase-3, PCNA expression, and TUNEL staining. The irradiated intestine demonstrated extensive loss in crypts and villi, disrupted mucosal lining with reduced xylose uptake and enhanced fluid level post 7-day radiation. Mice receiving G-003M before radiation showed significant protection to intestinal epithelium, better allocation of secretory goblet cells, recovery in absorption, and reduced intestinal oedema. Additionally, G-003M administration also prevented radiation induced ROS generation, lipid peroxidation (MDA levels) and maintained the intestinal glutathione pool compared to the irradiated animals. G-003M supplementation also resulted in restoration of intestinal mitochondrial membrane potential, which was otherwise depolarised by radiation treatment. Immunohistochemical analysis demonstrated decrease in c-PARP and caspase-3 expression in jejuna cross sections and upregulation of PCNA in G-003M treated crypt cells as compared to 9 Gy irradiated mice. Our findings show that G-003M augment survival of mice against lethal radiation by promoting structural and functional regeneration in intestinal tissue. This combination therefore can be effectively explored for preventing radiation induced GI toxicity." @default.
• W2776538095 created "2018-01-05" @default.
• W2776538095 creator A5028040873 @default.
• W2776538095 creator A5042903378 @default.
• W2776538095 creator A5085923251 @default.
• W2776538095 date "2018-01-02" @default.
• W2776538095 modified "2023-09-24" @default.
• W2776538095 title "Podophyllotoxin and rutin in combination prevents oxidative stress mediated cell death and advances revival of mice gastrointestine following lethal radiation injury" @default.
• W2776538095 cites W1571352200 @default.
• W2776538095 cites W1590457525 @default.
• W2776538095 cites W1861210509 @default.
• W2776538095 cites W1968635539 @default.
• W2776538095 cites W1978240169 @default.
• W2776538095 cites W1984284274 @default.
• W2776538095 cites W2011396346 @default.
• W2776538095 cites W2012815848 @default.
• W2776538095 cites W2023026201 @default.
• W2776538095 cites W2026261400 @default.
• W2776538095 cites W2030847930 @default.
• W2776538095 cites W2033575211 @default.
• W2776538095 cites W2038298358 @default.
• W2776538095 cites W2044351980 @default.
• W2776538095 cites W2060123892 @default.
• W2776538095 cites W2066486183 @default.
• W2776538095 cites W2073105285 @default.
• W2776538095 cites W2074634592 @default.
• W2776538095 cites W2078716275 @default.
• W2776538095 cites W2087377845 @default.
• W2776538095 cites W2087570664 @default.
• W2776538095 cites W2089736989 @default.
• W2776538095 cites W2093909112 @default.
• W2776538095 cites W2098923276 @default.
• W2776538095 cites W2105962951 @default.
• W2776538095 cites W2122636937 @default.
• W2776538095 cites W2127210744 @default.
• W2776538095 cites W2129689088 @default.
• W2776538095 cites W2132327565 @default.
• W2776538095 cites W2148576410 @default.
• W2776538095 cites W2153688304 @default.
• W2776538095 cites W2159179419 @default.
• W2776538095 cites W2162104253 @default.
• W2776538095 cites W2168284025 @default.
• W2776538095 cites W2301946772 @default.
• W2776538095 cites W2475132301 @default.
• W2776538095 cites W2512729123 @default.
• W2776538095 cites W2513659373 @default.
• W2776538095 cites W2567863767 @default.
• W2776538095 cites W2590521048 @default.
• W2776538095 cites W2623613999 @default.
• W2776538095 cites W2732383714 @default.
• W2776538095 cites W4245957869 @default.
• W2776538095 cites W4254408206 @default.
• W2776538095 cites W649920093 @default.
• W2776538095 doi "https://doi.org/10.1080/10715762.2017.1418982" @default.
• W2776538095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29251020" @default.
• W2776538095 hasPublicationYear "2018" @default.
• W2776538095 type Work @default.
• W2776538095 sameAs 2776538095 @default.
• W2776538095 citedByCount "13" @default.
• W2776538095 countsByYear W27765380952020 @default.
• W2776538095 countsByYear W27765380952021 @default.
• W2776538095 countsByYear W27765380952022 @default.
• W2776538095 countsByYear W27765380952023 @default.
• W2776538095 crossrefType "journal-article" @default.
• W2776538095 hasAuthorship W2776538095A5028040873 @default.
• W2776538095 hasAuthorship W2776538095A5042903378 @default.
• W2776538095 hasAuthorship W2776538095A5085923251 @default.
• W2776538095 hasConcept C126322002 @default.
• W2776538095 hasConcept C142724271 @default.
• W2776538095 hasConcept C16685009 @default.
• W2776538095 hasConcept C181199279 @default.
• W2776538095 hasConcept C185592680 @default.
• W2776538095 hasConcept C190283241 @default.
• W2776538095 hasConcept C204232928 @default.
• W2776538095 hasConcept C2775941134 @default.
• W2776538095 hasConcept C2776151105 @default.
• W2776538095 hasConcept C2780829032 @default.
• W2776538095 hasConcept C34688535 @default.
• W2776538095 hasConcept C529295009 @default.
• W2776538095 hasConcept C538909803 @default.
• W2776538095 hasConcept C55493867 @default.
• W2776538095 hasConcept C66090201 @default.
• W2776538095 hasConcept C71924100 @default.
• W2776538095 hasConceptScore W2776538095C126322002 @default.
• W2776538095 hasConceptScore W2776538095C142724271 @default.
• W2776538095 hasConceptScore W2776538095C16685009 @default.
• W2776538095 hasConceptScore W2776538095C181199279 @default.
• W2776538095 hasConceptScore W2776538095C185592680 @default.
• W2776538095 hasConceptScore W2776538095C190283241 @default.
• W2776538095 hasConceptScore W2776538095C204232928 @default.
• W2776538095 hasConceptScore W2776538095C2775941134 @default.
• W2776538095 hasConceptScore W2776538095C2776151105 @default.
• W2776538095 hasConceptScore W2776538095C2780829032 @default.
• W2776538095 hasConceptScore W2776538095C34688535 @default.
• W2776538095 hasConceptScore W2776538095C529295009 @default.
• W2776538095 hasConceptScore W2776538095C538909803 @default.
• W2776538095 hasConceptScore W2776538095C55493867 @default.
• W2776538095 hasConceptScore W2776538095C66090201 @default.

• next