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- W2776542125 abstract "To date, radiation therapy (RT)-induced tumor metastasis is widely recognized as a prominent problem which leads to an immense mortality in patients with lung cancer. As the active anti-oxidative components obtained from fruits and beverages such as grapes and red wine, oligomeric proanthocyanidins (OPCs) have been confirmed to exhibit a promising anti-tumor property in previous studies. However, few has put their focus on the impacts of OPCs on tumor post-irradiation progression, particularly on metastasis. This study investigated the advantages of OPCs in RT-elicited lung cancer metastasis. A549-bearing nude mice were administered with OPCs and/or RT treatment. The results indicated that OPCs markedly enhanced the radioresponses such as decreasing tumor’s volume and weight, with a significant reduction of MMP-2/-9 in A549-bearing xenografts (P" @default.
- W2776542125 created "2018-01-05" @default.
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- W2776542125 date "2017-09-01" @default.
- W2776542125 modified "2023-09-25" @default.
- W2776542125 title "OPCs abate the prometastatic potential elicited by irradiation in lung cancer" @default.
- W2776542125 doi "https://doi.org/10.1183/1393003.congress-2017.pa4208" @default.
- W2776542125 hasPublicationYear "2017" @default.
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